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Article: Detection of serum neopterin for early assessment of dengue virus infection

TitleDetection of serum neopterin for early assessment of dengue virus infection
Authors
Issue Date2006
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jinf
Citation
Journal Of Infection, 2006, v. 53 n. 3, p. 152-158 How to Cite?
AbstractObjective: Neopterin is generated and released in increased amounts by macrophages upon activation by interferon-γ during Th1-type immune response. The potential usefulness of neopterin in early prognostic information of dengue virus infection was investigated. Methods: Neopterin concentrations were determined in serum samples from 110 dengue fever (DF) patients. The neopterin levels were compared with those in 50 measles and 40 influenza patients; 155 healthy blood donors served as controls. Results: In acute sera of DF patients mean neopterin concentration was 48.2 nmol/L, which was higher than that in patients with measles (mean: 36.3 nmol/L) and influenza (18.8 nmol/L) and in healthy controls (6.7 nmol/L; P < 0.001). In the patients with confirmed DF, an early neopterin elevation was detected already at the first day after the onset of symptoms and rose to a maximum level of 54.3 nmol/L 4 days after the onset. Higher increase of neopterin level in DF patients was associated with longer duration of fever and thus predicted the clinical course of the disease. Conclusions: Neopterin concentrations were found significantly higher in DF patients compared with healthy controls and also with other viral infections (P < 0.001) and may allow early assessment of the severity of DF. © 2005 The British Infection Society.
Persistent Identifierhttp://hdl.handle.net/10722/79149
ISSN
2015 Impact Factor: 4.382
2015 SCImago Journal Rankings: 2.070
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, CPYen_HK
dc.contributor.authorChoi, JWYen_HK
dc.contributor.authorCao, KYen_HK
dc.contributor.authorWang, Men_HK
dc.contributor.authorGao, Yen_HK
dc.contributor.authorZhou, DHen_HK
dc.contributor.authorDi, Ben_HK
dc.contributor.authorXu, HFen_HK
dc.contributor.authorLeung, MFen_HK
dc.contributor.authorBergmann, Aen_HK
dc.contributor.authorLehmann, Men_HK
dc.contributor.authorNie, YMen_HK
dc.contributor.authorCautherley, GWHen_HK
dc.contributor.authorFuchs, Den_HK
dc.contributor.authorRenneberg, Ren_HK
dc.contributor.authorZheng, BJen_HK
dc.date.accessioned2010-09-06T07:51:11Z-
dc.date.available2010-09-06T07:51:11Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of Infection, 2006, v. 53 n. 3, p. 152-158en_HK
dc.identifier.issn0163-4453en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79149-
dc.description.abstractObjective: Neopterin is generated and released in increased amounts by macrophages upon activation by interferon-γ during Th1-type immune response. The potential usefulness of neopterin in early prognostic information of dengue virus infection was investigated. Methods: Neopterin concentrations were determined in serum samples from 110 dengue fever (DF) patients. The neopterin levels were compared with those in 50 measles and 40 influenza patients; 155 healthy blood donors served as controls. Results: In acute sera of DF patients mean neopterin concentration was 48.2 nmol/L, which was higher than that in patients with measles (mean: 36.3 nmol/L) and influenza (18.8 nmol/L) and in healthy controls (6.7 nmol/L; P < 0.001). In the patients with confirmed DF, an early neopterin elevation was detected already at the first day after the onset of symptoms and rose to a maximum level of 54.3 nmol/L 4 days after the onset. Higher increase of neopterin level in DF patients was associated with longer duration of fever and thus predicted the clinical course of the disease. Conclusions: Neopterin concentrations were found significantly higher in DF patients compared with healthy controls and also with other viral infections (P < 0.001) and may allow early assessment of the severity of DF. © 2005 The British Infection Society.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jinfen_HK
dc.relation.ispartofJournal of Infectionen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAntibodies, Viral - blooden_HK
dc.subject.meshChilden_HK
dc.subject.meshChild, Preschoolen_HK
dc.subject.meshDengue - blood - diagnosisen_HK
dc.subject.meshDengue Virus - immunologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFever - blooden_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfluenza, Human - blooden_HK
dc.subject.meshMaleen_HK
dc.subject.meshMeasles - blooden_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNeopterin - blooden_HK
dc.subject.meshTime Factorsen_HK
dc.titleDetection of serum neopterin for early assessment of dengue virus infectionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0163-4453&volume=53&issue=3&spage=152&epage=158&date=2006&atitle=Detection+of+serum+neopterin+for+early+assessment+of+dengue+virus+infection.en_HK
dc.identifier.emailZheng, BJ:bzheng@hkucc.hku.hken_HK
dc.identifier.authorityZheng, BJ=rp00353en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jinf.2005.11.008en_HK
dc.identifier.pmid16413058en_HK
dc.identifier.scopuseid_2-s2.0-33747201342en_HK
dc.identifier.hkuros132253en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33747201342&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume53en_HK
dc.identifier.issue3en_HK
dc.identifier.spage152en_HK
dc.identifier.epage158en_HK
dc.identifier.isiWOS:000240768400002-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, CPY=22033468200en_HK
dc.identifier.scopusauthoridChoi, JWY=8639814000en_HK
dc.identifier.scopusauthoridCao, KY=15845100900en_HK
dc.identifier.scopusauthoridWang, M=7406685232en_HK
dc.identifier.scopusauthoridGao, Y=7404706103en_HK
dc.identifier.scopusauthoridZhou, DH=7403395022en_HK
dc.identifier.scopusauthoridDi, B=6602190900en_HK
dc.identifier.scopusauthoridXu, HF=7407448207en_HK
dc.identifier.scopusauthoridLeung, MF=8639814200en_HK
dc.identifier.scopusauthoridBergmann, A=7006567116en_HK
dc.identifier.scopusauthoridLehmann, M=36644216200en_HK
dc.identifier.scopusauthoridNie, YM=14066620000en_HK
dc.identifier.scopusauthoridCautherley, GWH=8639815300en_HK
dc.identifier.scopusauthoridFuchs, D=35414205100en_HK
dc.identifier.scopusauthoridRenneberg, R=7006374338en_HK
dc.identifier.scopusauthoridZheng, BJ=7201780588en_HK

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