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Article: Duration of RT-PCR positivity in severe acute respiratory syndrome

TitleDuration of RT-PCR positivity in severe acute respiratory syndrome
Authors
Issue Date2005
PublisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
Citation
European Respiratory Journal, 2005, v. 25 n. 1, p. 12-14 How to Cite?
AbstractSevere acute respiratory syndrome (SARS) is a highly infectious respiratory infection with a high mortality. The duration of infectivity is unknown. The RT-PCR positivity for SARS-associated coronavirus (SARS-CoV) was followed in 45 virologically confirmed SARS patients. Serial RT-PCRs for SARS-CoV were performed in the nasopharyngeal aspirate, stool and urine of 45 SARS patients who survived until discharge. All patients had at least one site that was positive for SARS-CoV on presentation. Time to RT-PCR conversion was studied in all patients. There were 15 males (33.3%) and 30 females (66.7%), with a mean ± SD age of 40.7 ± 14.7 yrs. The median (range) time of RT-PCR conversion was 30 days (2-81). On discharge from the hospital, 18 (40%) remained RT-PCR positive in at least one site. For patients with positive RT-PCR on discharge, the median (range) time to RT-PCR conversion after discharge was 13 days (2-60). A significant proportion of severe acute respiratory syndrome patients remained RT-PCR positive for severe acute respiratory syndrome-associated coronavirus for a substantial duration after discharge. The clinical significance is unknown and this finding merits further study. It is prudent to advise patients to adhere to strict personal hygiene on discharge until RT-PCR becomes negative. Copyright©ERS Journals Ltd 2005.
Persistent Identifierhttp://hdl.handle.net/10722/79141
ISSN
2015 Impact Factor: 8.332
2015 SCImago Journal Rankings: 3.204
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChu, CMen_HK
dc.contributor.authorLeung, WSen_HK
dc.contributor.authorCheng, VCCen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorLin, AWNen_HK
dc.contributor.authorChan, VLen_HK
dc.contributor.authorLam, JYMen_HK
dc.contributor.authorChan, KSen_HK
dc.contributor.authorYuen, KYen_HK
dc.date.accessioned2010-09-06T07:51:05Z-
dc.date.available2010-09-06T07:51:05Z-
dc.date.issued2005en_HK
dc.identifier.citationEuropean Respiratory Journal, 2005, v. 25 n. 1, p. 12-14en_HK
dc.identifier.issn0903-1936en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79141-
dc.description.abstractSevere acute respiratory syndrome (SARS) is a highly infectious respiratory infection with a high mortality. The duration of infectivity is unknown. The RT-PCR positivity for SARS-associated coronavirus (SARS-CoV) was followed in 45 virologically confirmed SARS patients. Serial RT-PCRs for SARS-CoV were performed in the nasopharyngeal aspirate, stool and urine of 45 SARS patients who survived until discharge. All patients had at least one site that was positive for SARS-CoV on presentation. Time to RT-PCR conversion was studied in all patients. There were 15 males (33.3%) and 30 females (66.7%), with a mean ± SD age of 40.7 ± 14.7 yrs. The median (range) time of RT-PCR conversion was 30 days (2-81). On discharge from the hospital, 18 (40%) remained RT-PCR positive in at least one site. For patients with positive RT-PCR on discharge, the median (range) time to RT-PCR conversion after discharge was 13 days (2-60). A significant proportion of severe acute respiratory syndrome patients remained RT-PCR positive for severe acute respiratory syndrome-associated coronavirus for a substantial duration after discharge. The clinical significance is unknown and this finding merits further study. It is prudent to advise patients to adhere to strict personal hygiene on discharge until RT-PCR becomes negative. Copyright©ERS Journals Ltd 2005.en_HK
dc.languageengen_HK
dc.publisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.comen_HK
dc.relation.ispartofEuropean Respiratory Journalen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshConfidence Intervalsen_HK
dc.subject.meshDNA, Viral - analysisen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshProbabilityen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.subject.meshRisk Assessmenten_HK
dc.subject.meshSARS Virus - isolation & purificationen_HK
dc.subject.meshSensitivity and Specificityen_HK
dc.subject.meshSevere Acute Respiratory Syndrome - diagnosis - virologyen_HK
dc.subject.meshSeverity of Illness Indexen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshViral Loaden_HK
dc.titleDuration of RT-PCR positivity in severe acute respiratory syndromeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0903-1936&volume=25&issue=1&spage=12&epage=4&date=2005&atitle=Duration+of+RT-PCR+positivity+in+severe+acute+respiratory+syndrome.en_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1183/09031936.04.00057804en_HK
dc.identifier.pmid15640317-
dc.identifier.scopuseid_2-s2.0-13444288300en_HK
dc.identifier.hkuros100268en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-13444288300&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue1en_HK
dc.identifier.spage12en_HK
dc.identifier.epage14en_HK
dc.identifier.isiWOS:000226278400005-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridChu, CM=7404345558en_HK
dc.identifier.scopusauthoridLeung, WS=7201504471en_HK
dc.identifier.scopusauthoridCheng, VCC=23670479400en_HK
dc.identifier.scopusauthoridChan, KH=35338760600en_HK
dc.identifier.scopusauthoridLin, AWN=7402060859en_HK
dc.identifier.scopusauthoridChan, VL=7202655014en_HK
dc.identifier.scopusauthoridLam, JYM=16637812500en_HK
dc.identifier.scopusauthoridChan, KS=7406031627en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK

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