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Article: Influenza virus directly infects human natural killer cells and induces cell apoptosis

TitleInfluenza virus directly infects human natural killer cells and induces cell apoptosis
Authors
Issue Date2009
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2009, v. 83 n. 18, p. 9215-9222 How to Cite?
AbstractInfluenza is an acute respiratory viral disease that is transmitted in the first few days of infection. Evasion of host innate immune defenses, including natural killer (NK) cells, is important for the virus's success as a pathogen of humans and other animals. NK cells encounter influenza viruses within the microenvironment of infected cells and are important for host innate immunity during influenza virus infection. It is therefore important to investigate the direct effects of influenza virus on NK cells. In this study, we demonstrated for the first time that influenza virus directly infects and replicates in primary human NK cells. Viral entry into NK cells was mediated by both clathrin- and caveolin-dependent endocytosis rather than through macropinocytosis and was dependent on the sialic acids on cell surfaces. In addition, influenza virus infection induced a marked apoptosis of NK cells. Our findings suggest that influenza virus can directly target and kill NK cells, a potential novel strategy of influenza virus to evade the NK cell innate immune defense that is likely to facilitate viral transmission and may also contribute to virus pathogenesis. Copyright © 2009, American Society for Microbiology. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/79134
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Research Grants Council of Hong KongHKU 777108
University Grants Committee of the Hong Kong Special Administrative Region, ChinaAoE/M-12/06
University Research Committee, the University of Hong Kong200611159224
Edward Sai-Kim Hotung Pediatric Education and Research Fund
Funding Information:

This work was supported in part by the General Research Fund, Research Grants Council of Hong Kong ( grant HKU 777108 M to W. T.); the Area of Excellence Program on Influenza, supported by the University Grants Committee of the Hong Kong Special Administrative Region, China ( project no. AoE/M-12/06) ( M. P., Y.-L.L., and W. T.); Seed Funding for Basic Research, University Research Committee, the University of Hong Kong ( grant 200611159224 to W. T.); and the Edward Sai-Kim Hotung Pediatric Education and Research Fund (Y.-L. L.).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorMao, Hen_HK
dc.contributor.authorTu, Wen_HK
dc.contributor.authorQin, Gen_HK
dc.contributor.authorLaw, HKWen_HK
dc.contributor.authorSin, FSen_HK
dc.contributor.authorChan, PLen_HK
dc.contributor.authorLiu, Yen_HK
dc.contributor.authorLam, KTen_HK
dc.contributor.authorZheng, Jen_HK
dc.contributor.authorPeiris, Men_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2010-09-06T07:51:00Z-
dc.date.available2010-09-06T07:51:00Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Virology, 2009, v. 83 n. 18, p. 9215-9222en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/79134-
dc.description.abstractInfluenza is an acute respiratory viral disease that is transmitted in the first few days of infection. Evasion of host innate immune defenses, including natural killer (NK) cells, is important for the virus's success as a pathogen of humans and other animals. NK cells encounter influenza viruses within the microenvironment of infected cells and are important for host innate immunity during influenza virus infection. It is therefore important to investigate the direct effects of influenza virus on NK cells. In this study, we demonstrated for the first time that influenza virus directly infects and replicates in primary human NK cells. Viral entry into NK cells was mediated by both clathrin- and caveolin-dependent endocytosis rather than through macropinocytosis and was dependent on the sialic acids on cell surfaces. In addition, influenza virus infection induced a marked apoptosis of NK cells. Our findings suggest that influenza virus can directly target and kill NK cells, a potential novel strategy of influenza virus to evade the NK cell innate immune defense that is likely to facilitate viral transmission and may also contribute to virus pathogenesis. Copyright © 2009, American Society for Microbiology. All Rights Reserved.en_HK
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.en_HK
dc.rightsCopyright © American Society for Microbiology, [insert journal name, volume number, page numbers, and year]-
dc.subject.meshApoptosis-
dc.subject.meshCaveolins-
dc.subject.meshKiller Cells, Natural - virology-
dc.subject.meshOrthomyxoviridae - immunology - pathogenicity-
dc.subject.meshVirus Internalization-
dc.titleInfluenza virus directly infects human natural killer cells and induces cell apoptosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-538X&volume=83&issue=18&spage=9215&epage=9222&date=2009&atitle=Influenza+virus+directly+infects+human+natural+killer+cells+and+induces+cell+apoptosisen_HK
dc.identifier.emailMao, H: hwmau@hku.hken_HK
dc.identifier.emailTu, W: wwtu@hku.hken_HK
dc.identifier.emailLiu, Y: yinpingl@hku.hken_HK
dc.identifier.emailPeiris, M: malik@hkucc.hku.hken_HK
dc.identifier.emailLau, YL: lauylung@hku.hken_HK
dc.identifier.authorityMao, H=rp01595en_HK
dc.identifier.authorityTu, W=rp00416en_HK
dc.identifier.authorityLiu, Y=rp00269en_HK
dc.identifier.authorityPeiris, M=rp00410en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1128/JVI.00805-09en_HK
dc.identifier.pmid19587043-
dc.identifier.pmcidPMC2738258-
dc.identifier.scopuseid_2-s2.0-69449083335en_HK
dc.identifier.hkuros179383en_HK
dc.identifier.hkuros163406-
dc.identifier.hkuros192249-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-69449083335&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume83en_HK
dc.identifier.issue18en_HK
dc.identifier.spage9215en_HK
dc.identifier.epage9222en_HK
dc.identifier.eissn1098-5514-
dc.identifier.isiWOS:000269127000019-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.identifier.scopusauthoridMao, H=25632489000en_HK
dc.identifier.scopusauthoridTu, W=7006479236en_HK
dc.identifier.scopusauthoridQin, G=35085420900en_HK
dc.identifier.scopusauthoridLaw, HKW=7101939394en_HK
dc.identifier.scopusauthoridSin, FS=8968427000en_HK
dc.identifier.scopusauthoridChan, PL=25631876900en_HK
dc.identifier.scopusauthoridLiu, Y=35240639600en_HK
dc.identifier.scopusauthoridLam, KT=25630903400en_HK
dc.identifier.scopusauthoridZheng, J=55217878700en_HK
dc.identifier.scopusauthoridPeiris, M=7005486823en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.citeulike5655485-

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