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Article: Probiotic Lactobacillus rhamnosus GG enhances gastric ulcer healing in rats

TitleProbiotic Lactobacillus rhamnosus GG enhances gastric ulcer healing in rats
Authors
KeywordsAngiogenesis
B-cell lymphoma 2
Cell apoptosis
Cell proliferation
Epidermal growth factor receptor
Ornithine decarboxylase
Issue Date2007
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 2007, v. 565 n. 1-3, p. 171-179 How to Cite?
AbstractProbiotics are widely used as functional foods which have been advocated for the maintenance of gastrointestinal microflora equilibrium and treatment of gastrointestinal disorders. However, studying the role of probiotics in peptic ulcer disease is limited. The aim of the present study is to investigate the effect of a probiotic strain Lactobacillus rhamnosus GG on gastric ulcer and to elucidate the mechanisms involved. Gastric kissing ulcers were induced in rats by acetic acid (60% v/v). L. rhamnosus GG was given intragastrically at 10 8 cfu/day or 10 9 cfu/day for three consecutive days after ulcer induction. L. rhamnosus GG successfully colonized in the gastric mucosa especially at the ulcer margin. It also significantly and dose-dependently reduced gastric ulcer area. Cell apoptosis to cell proliferation ratio was strongly decreased and accompanied by significant up-regulation of ornithine decarboxylase (ODC) and B-cell lymphoma 2 (Bcl-2) protein expression at the ulcer margin. Angiogenesis was also significantly stimulated together with the induction of vascular endothelial growth factor (VEGF) expression. Furthermore, L. rhamnosus GG up-regulated the phosphorylation level of epidermal growth factor receptor (EGF receptor) without altering the total EGF receptor expression. These findings suggested that L. rhamnosus GG enhanced gastric ulcer healing via the attenuation of cell apoptosis to cell proliferation ratio and increase in angiogenesis. Regulators of these processes such as ODC, Bcl-2, VEGF and EGF receptor are likely to be involved in the healing action of L. rhamnosus GG for gastric ulcer. © 2007 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/79127
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, EKYen_HK
dc.contributor.authorYu, Len_HK
dc.contributor.authorWong, HPSen_HK
dc.contributor.authorWu, WKKen_HK
dc.contributor.authorShin, VYen_HK
dc.contributor.authorTai, EKKen_HK
dc.contributor.authorSo, WHLen_HK
dc.contributor.authorWoo, PCYen_HK
dc.contributor.authorCho, CHen_HK
dc.date.accessioned2010-09-06T07:50:55Z-
dc.date.available2010-09-06T07:50:55Z-
dc.date.issued2007en_HK
dc.identifier.citationEuropean Journal Of Pharmacology, 2007, v. 565 n. 1-3, p. 171-179en_HK
dc.identifier.issn0014-2999en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79127-
dc.description.abstractProbiotics are widely used as functional foods which have been advocated for the maintenance of gastrointestinal microflora equilibrium and treatment of gastrointestinal disorders. However, studying the role of probiotics in peptic ulcer disease is limited. The aim of the present study is to investigate the effect of a probiotic strain Lactobacillus rhamnosus GG on gastric ulcer and to elucidate the mechanisms involved. Gastric kissing ulcers were induced in rats by acetic acid (60% v/v). L. rhamnosus GG was given intragastrically at 10 8 cfu/day or 10 9 cfu/day for three consecutive days after ulcer induction. L. rhamnosus GG successfully colonized in the gastric mucosa especially at the ulcer margin. It also significantly and dose-dependently reduced gastric ulcer area. Cell apoptosis to cell proliferation ratio was strongly decreased and accompanied by significant up-regulation of ornithine decarboxylase (ODC) and B-cell lymphoma 2 (Bcl-2) protein expression at the ulcer margin. Angiogenesis was also significantly stimulated together with the induction of vascular endothelial growth factor (VEGF) expression. Furthermore, L. rhamnosus GG up-regulated the phosphorylation level of epidermal growth factor receptor (EGF receptor) without altering the total EGF receptor expression. These findings suggested that L. rhamnosus GG enhanced gastric ulcer healing via the attenuation of cell apoptosis to cell proliferation ratio and increase in angiogenesis. Regulators of these processes such as ODC, Bcl-2, VEGF and EGF receptor are likely to be involved in the healing action of L. rhamnosus GG for gastric ulcer. © 2007 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_HK
dc.relation.ispartofEuropean Journal of Pharmacologyen_HK
dc.rightsEuropean Journal of Pharmacology. Copyright © Elsevier BV.en_HK
dc.subjectAngiogenesisen_HK
dc.subjectB-cell lymphoma 2en_HK
dc.subjectCell apoptosisen_HK
dc.subjectCell proliferationen_HK
dc.subjectEpidermal growth factor receptoren_HK
dc.subjectOrnithine decarboxylaseen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshApoptosisen_HK
dc.subject.meshCell Proliferationen_HK
dc.subject.meshLactobacillus rhamnosusen_HK
dc.subject.meshMaleen_HK
dc.subject.meshNeovascularization, Physiologic - drug effectsen_HK
dc.subject.meshOrnithine Decarboxylase - biosynthesisen_HK
dc.subject.meshPhosphorylationen_HK
dc.subject.meshProbiotics - therapeutic useen_HK
dc.subject.meshProto-Oncogene Proteins c-bcl-2 - analysisen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshReceptor, Epidermal Growth Factor - metabolismen_HK
dc.subject.meshStomach - microbiologyen_HK
dc.subject.meshStomach Ulcer - drug therapyen_HK
dc.subject.meshVascular Endothelial Growth Factor A - analysisen_HK
dc.subject.meshWound Healing - drug effectsen_HK
dc.titleProbiotic Lactobacillus rhamnosus GG enhances gastric ulcer healing in ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0014-2999&volume=565&spage=171&epage=179&date=2007&atitle=Probiotic+Lactobacillus+rhamnosus+GG+enhances+gastric+ulcer+healing+in+ratsen_HK
dc.identifier.emailWong, HPS:hpswong@hkusua.hku.hken_HK
dc.identifier.emailWoo, PCY:pcywoo@hkucc.hku.hken_HK
dc.identifier.authorityWong, HPS=rp00808en_HK
dc.identifier.authorityWoo, PCY=rp00430en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ejphar.2007.02.050en_HK
dc.identifier.pmid17395175-
dc.identifier.scopuseid_2-s2.0-34249328530en_HK
dc.identifier.hkuros157307en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34249328530&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume565en_HK
dc.identifier.issue1-3en_HK
dc.identifier.spage171en_HK
dc.identifier.epage179en_HK
dc.identifier.isiWOS:000247336500024-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLam, EKY=8644138600en_HK
dc.identifier.scopusauthoridYu, L=16314581700en_HK
dc.identifier.scopusauthoridWong, HPS=8644138100en_HK
dc.identifier.scopusauthoridWu, WKK=18345422600en_HK
dc.identifier.scopusauthoridShin, VY=7003491170en_HK
dc.identifier.scopusauthoridTai, EKK=9842278900en_HK
dc.identifier.scopusauthoridSo, WHL=7004974020en_HK
dc.identifier.scopusauthoridWoo, PCY=7201801340en_HK
dc.identifier.scopusauthoridCho, CH=14067000400en_HK

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