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Article: Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome

TitleMolecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome
Authors
Issue Date2004
PublisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet
Citation
Lancet, 2004, v. 363 n. 9403, p. 99-104 How to Cite?
AbstractBackground: Severe acute respiratory syndrome (SARS) is a newly emerged disease caused by a novel coronavirus (SARS-CoV), which spread globally in early 2003, affecting over 30 countries. We have used molecular epidemiology to define the patterns of spread of the virus in Hong Kong and beyond. Methods: The case definition of SARS was based on that recommended by WHO. We genetically sequenced the gene for the S1 unit of the viral spike protein of viruses from patients with SARS in Hong Kong (138) and Guangdong (three) in February to April, 2003. We undertook phylogenetic comparisons with 27 other sequences available from public databases (Genbank). Findings: Most of the Hong Kong viruses (139/142), including those from a large outbreak in an apartment block, clustered closely together with the isolate from a single index case (HKU-33) who came from Guangdong to Hong Kong in late February. Three other isolates were genetically distinct from HKU-33 in Hong Kong during February, but none of these contributed substantially to the subsequent local outbreak. Viruses identified in Guangdong and Beijing were genetically more diverse. Interpretation: The molecular epidemiological evidence suggests that most SARS-CoV from the outbreak in Hong Kong, as well as the viruses from Canada, Vietnam, and Singapore, are genetically closely linked. Three viruses found in Hong Kong in February were phylogenetically distinct from the major cluster, which suggests that several introductions of the virus had occurred, but that only one was associated with the subsequent outbreak in Hong Kong, which in turn spread globally.
Persistent Identifierhttp://hdl.handle.net/10722/79115
ISSN
2015 Impact Factor: 44.002
2015 SCImago Journal Rankings: 14.638
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGuan, Yen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorZheng, Ben_HK
dc.contributor.authorPoon, LLMen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorZeng, FYen_HK
dc.contributor.authorChan, CWMen_HK
dc.contributor.authorChan, MNen_HK
dc.contributor.authorChen, JDen_HK
dc.contributor.authorChow, KYCen_HK
dc.contributor.authorHon, CCen_HK
dc.contributor.authorHui, KHen_HK
dc.contributor.authorLi, Jen_HK
dc.contributor.authorLi, VYYen_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorLeung, SWen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorLeung, FCen_HK
dc.date.accessioned2010-09-06T07:50:46Z-
dc.date.available2010-09-06T07:50:46Z-
dc.date.issued2004en_HK
dc.identifier.citationLancet, 2004, v. 363 n. 9403, p. 99-104en_HK
dc.identifier.issn0140-6736en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79115-
dc.description.abstractBackground: Severe acute respiratory syndrome (SARS) is a newly emerged disease caused by a novel coronavirus (SARS-CoV), which spread globally in early 2003, affecting over 30 countries. We have used molecular epidemiology to define the patterns of spread of the virus in Hong Kong and beyond. Methods: The case definition of SARS was based on that recommended by WHO. We genetically sequenced the gene for the S1 unit of the viral spike protein of viruses from patients with SARS in Hong Kong (138) and Guangdong (three) in February to April, 2003. We undertook phylogenetic comparisons with 27 other sequences available from public databases (Genbank). Findings: Most of the Hong Kong viruses (139/142), including those from a large outbreak in an apartment block, clustered closely together with the isolate from a single index case (HKU-33) who came from Guangdong to Hong Kong in late February. Three other isolates were genetically distinct from HKU-33 in Hong Kong during February, but none of these contributed substantially to the subsequent local outbreak. Viruses identified in Guangdong and Beijing were genetically more diverse. Interpretation: The molecular epidemiological evidence suggests that most SARS-CoV from the outbreak in Hong Kong, as well as the viruses from Canada, Vietnam, and Singapore, are genetically closely linked. Three viruses found in Hong Kong in February were phylogenetically distinct from the major cluster, which suggests that several introductions of the virus had occurred, but that only one was associated with the subsequent outbreak in Hong Kong, which in turn spread globally.en_HK
dc.languageengen_HK
dc.publisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lanceten_HK
dc.relation.ispartofLanceten_HK
dc.subject.meshCanada - epidemiologyen_HK
dc.subject.meshDatabases, Nucleic Acid - statistics & numerical dataen_HK
dc.subject.meshDisease Outbreaks - statistics & numerical dataen_HK
dc.subject.meshGenome, Viralen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMolecular Epidemiologyen_HK
dc.subject.meshNucleic Acid Amplification Techniques - methodsen_HK
dc.subject.meshRNA, Viral - geneticsen_HK
dc.subject.meshSARS Virus - geneticsen_HK
dc.subject.meshSevere Acute Respiratory Syndrome - epidemiology - transmission - virologyen_HK
dc.subject.meshSingapore - epidemiologyen_HK
dc.subject.meshVietnam - epidemiologyen_HK
dc.titleMolecular epidemiology of the novel coronavirus that causes severe acute respiratory syndromeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0140-6736&volume=363&spage=99&epage=104&date=2004&atitle=Molecular+epidemiology+of+the+novel+coronavirus+that+causes+severe+acute+respiratory+syndromeen_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailZheng, B: bzheng@hkucc.hku.hken_HK
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hken_HK
dc.identifier.emailHui, KH: rkhhui@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.emailLeung, FC: fcleung@hkucc.hku.hken_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityZheng, B=rp00353en_HK
dc.identifier.authorityPoon, LLM=rp00484en_HK
dc.identifier.authorityHui, KH=rp00711en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityLeung, FC=rp00731en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0140-6736(03)15259-2en_HK
dc.identifier.pmid14726162-
dc.identifier.scopuseid_2-s2.0-9144249102en_HK
dc.identifier.hkuros85665en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-9144249102&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume363en_HK
dc.identifier.issue9403en_HK
dc.identifier.spage99en_HK
dc.identifier.epage104en_HK
dc.identifier.isiWOS:000187939200006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridZheng, B=7201780588en_HK
dc.identifier.scopusauthoridPoon, LLM=7005441747en_HK
dc.identifier.scopusauthoridChan, KH=7406034307en_HK
dc.identifier.scopusauthoridZeng, FY=7202911544en_HK
dc.identifier.scopusauthoridChan, CWM=7404813871en_HK
dc.identifier.scopusauthoridChan, MN=36941301400en_HK
dc.identifier.scopusauthoridChen, JD=8320191000en_HK
dc.identifier.scopusauthoridChow, KYC=7202180875en_HK
dc.identifier.scopusauthoridHon, CC=7003617137en_HK
dc.identifier.scopusauthoridHui, KH=7103304764en_HK
dc.identifier.scopusauthoridLi, J=27171035300en_HK
dc.identifier.scopusauthoridLi, VYY=7202621838en_HK
dc.identifier.scopusauthoridWang, Y=8710320600en_HK
dc.identifier.scopusauthoridLeung, SW=55243485200en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridLeung, FC=7103078633en_HK

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