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Article: Evolving complexities of influenza virus and its receptors

TitleEvolving complexities of influenza virus and its receptors
Authors
Issue Date2008
PublisherElsevier Ltd, Trends Journals. The Journal's web site is located at http://www.elsevier.com/locate/tim
Citation
Trends In Microbiology, 2008, v. 16 n. 4, p. 149-157 How to Cite?
AbstractSialic acids (Sias) are regarded as receptors for influenza viruses and are usually bound to galactose (Gal) in an α2-3 or α2-6 configuration. The detection of these Sia configurations in tissues has commonly been through the use of plant lectins that are able to identify which cells contain Siaα2-3- and Siaα2-6-linked glycans, although other techniques for receptor distribution have been used. Initial experiments indicated that avian versus human influenza virus binding was determined by either Siaα2-6 or Siaα2-3 expression. In this review, we suggest that the distribution and detection of these terminal Siaα2-3- and Siaα2-6-linked receptors within the respiratory tract might not be as clear cut as has been reported. We will also review how other viral and receptor components might act as determinants for successful viral replication and transmission. Understanding these additional components is important in comprehending the infection and the transmission of both existing human influenza viruses and newly emerging avian influenza viruses. © 2008 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/79114
ISSN
2015 Impact Factor: 9.5
2015 SCImago Journal Rankings: 5.285
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNicholls, JMen_HK
dc.contributor.authorChan, RWYen_HK
dc.contributor.authorRussell, RJen_HK
dc.contributor.authorAir, GMen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.date.accessioned2010-09-06T07:50:45Z-
dc.date.available2010-09-06T07:50:45Z-
dc.date.issued2008en_HK
dc.identifier.citationTrends In Microbiology, 2008, v. 16 n. 4, p. 149-157en_HK
dc.identifier.issn0966-842Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/79114-
dc.description.abstractSialic acids (Sias) are regarded as receptors for influenza viruses and are usually bound to galactose (Gal) in an α2-3 or α2-6 configuration. The detection of these Sia configurations in tissues has commonly been through the use of plant lectins that are able to identify which cells contain Siaα2-3- and Siaα2-6-linked glycans, although other techniques for receptor distribution have been used. Initial experiments indicated that avian versus human influenza virus binding was determined by either Siaα2-6 or Siaα2-3 expression. In this review, we suggest that the distribution and detection of these terminal Siaα2-3- and Siaα2-6-linked receptors within the respiratory tract might not be as clear cut as has been reported. We will also review how other viral and receptor components might act as determinants for successful viral replication and transmission. Understanding these additional components is important in comprehending the infection and the transmission of both existing human influenza viruses and newly emerging avian influenza viruses. © 2008 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ltd, Trends Journals. The Journal's web site is located at http://www.elsevier.com/locate/timen_HK
dc.relation.ispartofTrends in Microbiologyen_HK
dc.rightsTrends in Microbiology. Copyright © Elsevier Ltd, Trends Journals.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshHemagglutinin Glycoproteins, Influenza Virus - chemistry - genetics - metabolismen_HK
dc.subject.meshHost-Pathogen Interactionsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfluenza A Virus, H3N2 Subtype - metabolismen_HK
dc.subject.meshInfluenza A Virus, H5N1 Subtype - metabolismen_HK
dc.subject.meshInfluenza A virus - genetics - metabolismen_HK
dc.subject.meshModels, Molecularen_HK
dc.subject.meshReceptors, Cell Surface - chemistry - genetics - metabolismen_HK
dc.subject.meshReceptors, Virus - chemistry - genetics - metabolismen_HK
dc.subject.meshSwineen_HK
dc.titleEvolving complexities of influenza virus and its receptorsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0966-842X&volume=16&issue=4&spage=149&epage=157&date=2008&atitle=Evolving+complexities+of+influenza+virus+and+its+receptorsen_HK
dc.identifier.emailNicholls, JM: jmnichol@hkucc.hku.hken_HK
dc.identifier.emailChan, RWY: reneewy@hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.authorityNicholls, JM=rp00364en_HK
dc.identifier.authorityChan, RWY=rp01596en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.tim.2008.01.008en_HK
dc.identifier.pmid18375125-
dc.identifier.scopuseid_2-s2.0-41549117878en_HK
dc.identifier.hkuros147206en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-41549117878&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue4en_HK
dc.identifier.spage149en_HK
dc.identifier.epage157en_HK
dc.identifier.eissn1878-4380-
dc.identifier.isiWOS:000255346100004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridNicholls, JM=7201463077en_HK
dc.identifier.scopusauthoridChan, RWY=26661379100en_HK
dc.identifier.scopusauthoridRussell, RJ=7403934759en_HK
dc.identifier.scopusauthoridAir, GM=7005747759en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK

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