File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The development of vaccines against SARS corona virus in mice and SCID-PBL/hu mice

TitleThe development of vaccines against SARS corona virus in mice and SCID-PBL/hu mice
Authors
KeywordsHuman CTL
Sars DNA vaccine
SCID-PBL/hu
Issue Date2005
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccine
Citation
Vaccine, 2005, v. 23 n. 17-18, p. 2269-2272 How to Cite?
AbstractWe have investigated to develop novel vaccines against SARS CoV using cDNA constructs encoding the structural antigen; spike protein (S), membrane protein (M), envelope protein (E), or nucleocapsid (N) protein, derived from SARS CoV. Mice vaccinated with SARS-N or -M DNA using pcDNA 3.1(+) plasmid vector showed T cell immune responses (CTL induction and proliferation) against N or M protein, respectively. CTL responses were also detected to SARS DNA-transfected type II alveolar epithelial cells (T7 cell clone), which are thought to be initial target cells for SARS virus infection in human. To determine whether these DNA vaccines could induce T cell immune responses in humans as well as in mice, SCID-PBL/hu mice was immunized with these DNA vaccines. As expected, virus-specific CTL responses and T cell proliferation were induced from human T cells. SARS-N and SARS-M DNA vaccines and SCID-PBL/hu mouse model will be important in the development of protective vaccines. © 2005 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/79090
ISSN
2015 Impact Factor: 3.413
2015 SCImago Journal Rankings: 2.044
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorOkada, Men_HK
dc.contributor.authorTakemoto, Yen_HK
dc.contributor.authorOkuno, Yen_HK
dc.contributor.authorHashimoto, Sen_HK
dc.contributor.authorYoshida, Sen_HK
dc.contributor.authorFukunaga, Yen_HK
dc.contributor.authorTanaka, Ten_HK
dc.contributor.authorKita, Yen_HK
dc.contributor.authorKuwayama, Sen_HK
dc.contributor.authorMuraki, Yen_HK
dc.contributor.authorKanamaru, Nen_HK
dc.contributor.authorTakai, Hen_HK
dc.contributor.authorOkada, Cen_HK
dc.contributor.authorSakaguchi, Yen_HK
dc.contributor.authorFurukawa, Ien_HK
dc.contributor.authorYamada, Ken_HK
dc.contributor.authorMatsumoto, Men_HK
dc.contributor.authorKase, Ten_HK
dc.contributor.authorDemello, DEen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorChen, PJen_HK
dc.contributor.authorYamamoto, Nen_HK
dc.contributor.authorYoshinaka, Yen_HK
dc.contributor.authorNomura, Ten_HK
dc.contributor.authorIshida, Ien_HK
dc.contributor.authorMorikawa, Sen_HK
dc.contributor.authorTashiro, Men_HK
dc.contributor.authorSakatani, Men_HK
dc.date.accessioned2010-09-06T07:50:28Z-
dc.date.available2010-09-06T07:50:28Z-
dc.date.issued2005en_HK
dc.identifier.citationVaccine, 2005, v. 23 n. 17-18, p. 2269-2272en_HK
dc.identifier.issn0264-410Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/79090-
dc.description.abstractWe have investigated to develop novel vaccines against SARS CoV using cDNA constructs encoding the structural antigen; spike protein (S), membrane protein (M), envelope protein (E), or nucleocapsid (N) protein, derived from SARS CoV. Mice vaccinated with SARS-N or -M DNA using pcDNA 3.1(+) plasmid vector showed T cell immune responses (CTL induction and proliferation) against N or M protein, respectively. CTL responses were also detected to SARS DNA-transfected type II alveolar epithelial cells (T7 cell clone), which are thought to be initial target cells for SARS virus infection in human. To determine whether these DNA vaccines could induce T cell immune responses in humans as well as in mice, SCID-PBL/hu mice was immunized with these DNA vaccines. As expected, virus-specific CTL responses and T cell proliferation were induced from human T cells. SARS-N and SARS-M DNA vaccines and SCID-PBL/hu mouse model will be important in the development of protective vaccines. © 2005 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccineen_HK
dc.relation.ispartofVaccineen_HK
dc.rightsVaccine. Copyright © Elsevier Ltd.en_HK
dc.subjectHuman CTLen_HK
dc.subjectSars DNA vaccineen_HK
dc.subjectSCID-PBL/huen_HK
dc.titleThe development of vaccines against SARS corona virus in mice and SCID-PBL/hu miceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0264-410X&volume=23 &issue=17-18&spage=2269&epage=72&date=2005&atitle=The+development+of+vaccines+against+SARS+corona+virus+in+mice+and+SCID-PBL/hu+mice.en_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.vaccine.2005.01.036en_HK
dc.identifier.pmid15755609-
dc.identifier.scopuseid_2-s2.0-20044381691en_HK
dc.identifier.hkuros106345en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-20044381691&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue17-18en_HK
dc.identifier.spage2269en_HK
dc.identifier.epage2272en_HK
dc.identifier.isiWOS:000227898700047-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridOkada, M=8247382100en_HK
dc.identifier.scopusauthoridTakemoto, Y=35238734900en_HK
dc.identifier.scopusauthoridOkuno, Y=7202193504en_HK
dc.identifier.scopusauthoridHashimoto, S=8208749500en_HK
dc.identifier.scopusauthoridYoshida, S=35458480200en_HK
dc.identifier.scopusauthoridFukunaga, Y=23496339500en_HK
dc.identifier.scopusauthoridTanaka, T=7406729675en_HK
dc.identifier.scopusauthoridKita, Y=35237454300en_HK
dc.identifier.scopusauthoridKuwayama, S=8208749200en_HK
dc.identifier.scopusauthoridMuraki, Y=8247380200en_HK
dc.identifier.scopusauthoridKanamaru, N=8247380300en_HK
dc.identifier.scopusauthoridTakai, H=8247380400en_HK
dc.identifier.scopusauthoridOkada, C=23498601500en_HK
dc.identifier.scopusauthoridSakaguchi, Y=8247380600en_HK
dc.identifier.scopusauthoridFurukawa, I=36742646100en_HK
dc.identifier.scopusauthoridYamada, K=35239179400en_HK
dc.identifier.scopusauthoridMatsumoto, M=7404939861en_HK
dc.identifier.scopusauthoridKase, T=7005279800en_HK
dc.identifier.scopusauthoridDemello, DE=7006546651en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridChen, PJ=7408354514en_HK
dc.identifier.scopusauthoridYamamoto, N=7403608342en_HK
dc.identifier.scopusauthoridYoshinaka, Y=7003532886en_HK
dc.identifier.scopusauthoridNomura, T=54409213700en_HK
dc.identifier.scopusauthoridIshida, I=18344116900en_HK
dc.identifier.scopusauthoridMorikawa, S=7102226341en_HK
dc.identifier.scopusauthoridTashiro, M=7201482415en_HK
dc.identifier.scopusauthoridSakatani, M=7006692689en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats