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Article: The aetiology, origins, and diagnosis of severe acute respiratory syndrome

TitleThe aetiology, origins, and diagnosis of severe acute respiratory syndrome
Authors
Issue Date2004
PublisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/j.lancetid
Citation
Lancet Infectious Diseases, 2004, v. 4 n. 11, p. 663-671 How to Cite?
AbstractSevere acute respiratory syndrome (SARS) is a new infectious disease that first emerged in Guangdong province, China, in November, 2002. A novel coronavirus was later identified in patients with SARS. The detection of the virus in these patients, its absence in healthy controls or other patients with atypical pneumonia, and the reproduction of a similar disease in a relevant animal model fulfilled Koch's postulates for implicating this coronavirus as the causal agent of SARS. The full genome sequence was determined within weeks of the virus's identification. The rapid progress in the aetiology, the development of laboratory diagnostic tests, and the defining of routes of viral transmission were facilitated through a unique WHO-coordinated virtual network of laboratories, which shared information on a real-time basis through daily teleconferences. Subsequent studies have indicated that the SARS coronavirus is of animal origin, that its precursor is still present in animal populations within the region, and that live-animal markets in southern China may have provided the animal-human interphase that allowed this precursor virus to adapt to human-human transmission. These findings underscore the potential for the re-emergence of SARS and the need for laboratory tests for early diagnosis. However, the low viral load in the respiratory tract makes early diagnosis of SARS a diagnostic challenge, although improvements in the sensitivity of molecular diagnostic methods continue to be made.
Persistent Identifierhttp://hdl.handle.net/10722/79086
ISSN
2015 Impact Factor: 21.372
2015 SCImago Journal Rankings: 11.233
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPoon, LLMen_HK
dc.contributor.authorGuan, Yen_HK
dc.contributor.authorNicholls, JMen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.date.accessioned2010-09-06T07:50:25Z-
dc.date.available2010-09-06T07:50:25Z-
dc.date.issued2004en_HK
dc.identifier.citationLancet Infectious Diseases, 2004, v. 4 n. 11, p. 663-671en_HK
dc.identifier.issn1473-3099en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79086-
dc.description.abstractSevere acute respiratory syndrome (SARS) is a new infectious disease that first emerged in Guangdong province, China, in November, 2002. A novel coronavirus was later identified in patients with SARS. The detection of the virus in these patients, its absence in healthy controls or other patients with atypical pneumonia, and the reproduction of a similar disease in a relevant animal model fulfilled Koch's postulates for implicating this coronavirus as the causal agent of SARS. The full genome sequence was determined within weeks of the virus's identification. The rapid progress in the aetiology, the development of laboratory diagnostic tests, and the defining of routes of viral transmission were facilitated through a unique WHO-coordinated virtual network of laboratories, which shared information on a real-time basis through daily teleconferences. Subsequent studies have indicated that the SARS coronavirus is of animal origin, that its precursor is still present in animal populations within the region, and that live-animal markets in southern China may have provided the animal-human interphase that allowed this precursor virus to adapt to human-human transmission. These findings underscore the potential for the re-emergence of SARS and the need for laboratory tests for early diagnosis. However, the low viral load in the respiratory tract makes early diagnosis of SARS a diagnostic challenge, although improvements in the sensitivity of molecular diagnostic methods continue to be made.en_HK
dc.languageengen_HK
dc.publisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/j.lancetiden_HK
dc.relation.ispartofLancet Infectious Diseasesen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshChina - epidemiologyen_HK
dc.subject.meshCommunicable Diseases, Emergingen_HK
dc.subject.meshDisease Outbreaksen_HK
dc.subject.meshDisease Reservoirsen_HK
dc.subject.meshGenome, Viralen_HK
dc.subject.meshHumansen_HK
dc.subject.meshPhylogenyen_HK
dc.subject.meshRNA, Viral - analysisen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.subject.meshSARS Virus - geneticsen_HK
dc.subject.meshSevere Acute Respiratory Syndrome - diagnosis - epidemiology - prevention & control - transmission - virologyen_HK
dc.titleThe aetiology, origins, and diagnosis of severe acute respiratory syndromeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0140-6736&volume=4&issue=11&spage=663&epage=71&date=2004&atitle=The+aetiology,+origins,+and+diagnosis+of+severe+acute+respiratory+syndrome.en_HK
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.emailNicholls, JM: jmnichol@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.authorityPoon, LLM=rp00484en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.identifier.authorityNicholls, JM=rp00364en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S1473-3099(04)01172-7en_HK
dc.identifier.pmid15522678en_HK
dc.identifier.scopuseid_2-s2.0-7544240839en_HK
dc.identifier.hkuros106712en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-7544240839&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume4en_HK
dc.identifier.issue11en_HK
dc.identifier.spage663en_HK
dc.identifier.epage671en_HK
dc.identifier.isiWOS:000224782300018-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridPoon, LLM=7005441747en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.scopusauthoridNicholls, JM=7201463077en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK

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