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Article: Influenza A H5N1 replication sites in humans

TitleInfluenza A H5N1 replication sites in humans
Authors
Issue Date2005
PublisherUS Department of Health and Human Services, Centers for Disease Control and Prevention. The Journal's web site is located at http://www.cdc.gov/ncidod/EID/index.htm
Citation
Emerging Infectious Diseases, 2005, v. 11 n. 7, p. 1036-1041 How to Cite?
AbstractTissue tropism and pathogenesis of influenza A virus subtype H5N1 disease in humans is not well defined. In mammalian experimental models, H5N1 influenza is a disseminated disease. However, limited previous data from human autopsies have not shown evidence of virus dissemination beyond the lung. We investigated a patient with fatal H5N1 influenza. Viral RNA was detected by reverse transcription-polymerase chain reaction in lung, intestine, and spleen tissues, but positive-stranded viral RNA indicating virus replication was confined to the lung and intestine. Viral antigen was detected in pneumocytes by immunohistochemical tests. Tumor necrosis factor-α mRNA was seen in lung tissue. In contrast to disseminated infection documented in other mammals and birds, H5N1 viral replication in humans may be restricted to the lung and intestine, and the major site of H5N1 viral replication in the lung is the pneumocyte.
Persistent Identifierhttp://hdl.handle.net/10722/79076
ISSN
2015 Impact Factor: 6.994
2015 SCImago Journal Rankings: 3.023
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorUiprasertkul, Men_HK
dc.contributor.authorPuthavathana, Pen_HK
dc.contributor.authorSangsiriwut, Ken_HK
dc.contributor.authorPooruk, Pen_HK
dc.contributor.authorSrisook, Ken_HK
dc.contributor.authorPeiris, Men_HK
dc.contributor.authorNicholls, JMen_HK
dc.contributor.authorChokephaibulkit, Ken_HK
dc.contributor.authorVanprapar, Nen_HK
dc.contributor.authorAuewarakul, Pen_HK
dc.date.accessioned2010-09-06T07:50:17Z-
dc.date.available2010-09-06T07:50:17Z-
dc.date.issued2005en_HK
dc.identifier.citationEmerging Infectious Diseases, 2005, v. 11 n. 7, p. 1036-1041en_HK
dc.identifier.issn1080-6040en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79076-
dc.description.abstractTissue tropism and pathogenesis of influenza A virus subtype H5N1 disease in humans is not well defined. In mammalian experimental models, H5N1 influenza is a disseminated disease. However, limited previous data from human autopsies have not shown evidence of virus dissemination beyond the lung. We investigated a patient with fatal H5N1 influenza. Viral RNA was detected by reverse transcription-polymerase chain reaction in lung, intestine, and spleen tissues, but positive-stranded viral RNA indicating virus replication was confined to the lung and intestine. Viral antigen was detected in pneumocytes by immunohistochemical tests. Tumor necrosis factor-α mRNA was seen in lung tissue. In contrast to disseminated infection documented in other mammals and birds, H5N1 viral replication in humans may be restricted to the lung and intestine, and the major site of H5N1 viral replication in the lung is the pneumocyte.en_HK
dc.languageengen_HK
dc.publisherUS Department of Health and Human Services, Centers for Disease Control and Prevention. The Journal's web site is located at http://www.cdc.gov/ncidod/EID/index.htmen_HK
dc.relation.ispartofEmerging Infectious Diseasesen_HK
dc.subject.meshChilden_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfluenza A Virus, H5N1 Subtypeen_HK
dc.subject.meshInfluenza A virus - physiologyen_HK
dc.subject.meshInfluenza, Human - pathology - virologyen_HK
dc.subject.meshIntestines - virologyen_HK
dc.subject.meshLung - pathology - virologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshVirus Replication - physiologyen_HK
dc.titleInfluenza A H5N1 replication sites in humansen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1080-6040&volume=11&issue=7&spage=1036&epage=1041&date=2005&atitle=Influenza+A+H5N1+replication+sites+in+humansen_HK
dc.identifier.emailPeiris, M: malik@hkucc.hku.hken_HK
dc.identifier.emailNicholls, JM: jmnichol@hkucc.hku.hken_HK
dc.identifier.authorityPeiris, M=rp00410en_HK
dc.identifier.authorityNicholls, JM=rp00364en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid16022777en_HK
dc.identifier.scopuseid_2-s2.0-21144453617en_HK
dc.identifier.hkuros105227en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-21144453617&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1036en_HK
dc.identifier.epage1041en_HK
dc.identifier.isiWOS:000230106600008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridUiprasertkul, M=6508217319en_HK
dc.identifier.scopusauthoridPuthavathana, P=7004642707en_HK
dc.identifier.scopusauthoridSangsiriwut, K=6506702702en_HK
dc.identifier.scopusauthoridPooruk, P=8611889800en_HK
dc.identifier.scopusauthoridSrisook, K=8611889900en_HK
dc.identifier.scopusauthoridPeiris, M=7005486823en_HK
dc.identifier.scopusauthoridNicholls, JM=7201463077en_HK
dc.identifier.scopusauthoridChokephaibulkit, K=7003974471en_HK
dc.identifier.scopusauthoridVanprapar, N=6701697019en_HK
dc.identifier.scopusauthoridAuewarakul, P=6603673806en_HK

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