File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Association between polyomaviruria and microscopic haematuria in bone marrow transplant recipients

TitleAssociation between polyomaviruria and microscopic haematuria in bone marrow transplant recipients
Authors
Issue Date1994
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jinf
Citation
Journal Of Infection, 1994, v. 29 n. 2, p. 139-146 How to Cite?
AbstractThe association of polyomaviruria and microscopic haematuria was studied by the use of electron microscopy (EM) and the polymerase chain reaction (PCR) in bone marrow transplant (BMT) recipients. The incidence of BK virus (BKV) and JC virus (JCV) excretion was further elucidated by means of restriction enzyme analysis of the PCR products. Polyomaviruses were detected in 43 (51.2%) of the 84 samples, 13 (30.2%) of which had a virus concentration detectable by EM. By typing with BamHI cleavage, 29 (67.4%) of the 43 positive patients were found to be excreting only BKV and the remaining 14% (32.6%) were excreting both BKV and JCV. Microscopic haematuria was present in 17 (20.2%) of 84 urine samples collected from different patients within 4 months post-transplant. The incidence of microscopic haematuria was significantly higher, 34.9% (P < 0.01), in patients with polyomaviruria than in those without (4.9%) but no difference was observed between the BKV-excreting and BKV/JCV-co-excreting patients. Microscopic haematuria was not present, however, in 53.8 and 65.2% of polyomavirus-excreting patients when virus was detected by EM and PCR respectively. While most episodes of microscopic haematuria observed were self-limiting and asymptomatic, three patients excreting polyomavirus had symptoms of cystitis and one of them had renal impairment that was otherwise unexplained. We thus conclude that polyomaviruses probably contribute to damage of urinary tract tissue in some BMT recipients.
Persistent Identifierhttp://hdl.handle.net/10722/79057
ISSN
2015 Impact Factor: 4.382
2015 SCImago Journal Rankings: 2.070
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, PKSen_HK
dc.contributor.authorIp, KWYen_HK
dc.contributor.authorShiu, SYWen_HK
dc.contributor.authorChiu, EKWen_HK
dc.contributor.authorWong, MPen_HK
dc.contributor.authorYuen, KYen_HK
dc.date.accessioned2010-09-06T07:50:04Z-
dc.date.available2010-09-06T07:50:04Z-
dc.date.issued1994en_HK
dc.identifier.citationJournal Of Infection, 1994, v. 29 n. 2, p. 139-146en_HK
dc.identifier.issn0163-4453en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79057-
dc.description.abstractThe association of polyomaviruria and microscopic haematuria was studied by the use of electron microscopy (EM) and the polymerase chain reaction (PCR) in bone marrow transplant (BMT) recipients. The incidence of BK virus (BKV) and JC virus (JCV) excretion was further elucidated by means of restriction enzyme analysis of the PCR products. Polyomaviruses were detected in 43 (51.2%) of the 84 samples, 13 (30.2%) of which had a virus concentration detectable by EM. By typing with BamHI cleavage, 29 (67.4%) of the 43 positive patients were found to be excreting only BKV and the remaining 14% (32.6%) were excreting both BKV and JCV. Microscopic haematuria was present in 17 (20.2%) of 84 urine samples collected from different patients within 4 months post-transplant. The incidence of microscopic haematuria was significantly higher, 34.9% (P < 0.01), in patients with polyomaviruria than in those without (4.9%) but no difference was observed between the BKV-excreting and BKV/JCV-co-excreting patients. Microscopic haematuria was not present, however, in 53.8 and 65.2% of polyomavirus-excreting patients when virus was detected by EM and PCR respectively. While most episodes of microscopic haematuria observed were self-limiting and asymptomatic, three patients excreting polyomavirus had symptoms of cystitis and one of them had renal impairment that was otherwise unexplained. We thus conclude that polyomaviruses probably contribute to damage of urinary tract tissue in some BMT recipients.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jinfen_HK
dc.relation.ispartofJournal of Infectionen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshBK Virus - isolation & purificationen_HK
dc.subject.meshBase Sequenceen_HK
dc.subject.meshBone Marrow Transplantationen_HK
dc.subject.meshChilden_HK
dc.subject.meshChild, Preschoolen_HK
dc.subject.meshHematuria - etiology - virologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfanten_HK
dc.subject.meshJC Virus - isolation & purificationen_HK
dc.subject.meshMicroscopy, Electronen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.subject.meshPolymerase Chain Reactionen_HK
dc.subject.meshPolyomavirus Infections - complications - urine - virologyen_HK
dc.subject.meshTumor Virus Infections - complications - urine - virologyen_HK
dc.titleAssociation between polyomaviruria and microscopic haematuria in bone marrow transplant recipientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0163-4453&volume=29&spage=139&epage=146&date=1994&atitle=Association+between+polyomaviruria+and+microscopic+haematuria+in+bone+marrow+transplant+recipientsen_HK
dc.identifier.emailShiu, SYW: sywshiu@hkucc.hku.hken_HK
dc.identifier.emailWong, MP: mwpik@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityShiu, SYW=rp00384en_HK
dc.identifier.authorityWong, MP=rp00348en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0163-4453(94)90602-5en_HK
dc.identifier.pmid7806877en_HK
dc.identifier.scopuseid_2-s2.0-0027965148en_HK
dc.identifier.hkuros4345en_HK
dc.identifier.volume29en_HK
dc.identifier.issue2en_HK
dc.identifier.spage139en_HK
dc.identifier.epage146en_HK
dc.identifier.isiWOS:A1994PG58600004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, PKS=7403497792en_HK
dc.identifier.scopusauthoridIp, KWY=7006315589en_HK
dc.identifier.scopusauthoridShiu, SYW=7005550655en_HK
dc.identifier.scopusauthoridChiu, EKW=24827833600en_HK
dc.identifier.scopusauthoridWong, MP=7403907887en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats