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Article: Avian influenza virus (H5N1): A threat to human health

TitleAvian influenza virus (H5N1): A threat to human health
Authors
Issue Date2007
PublisherAmerican Society for Microbiology.
Citation
Clinical Microbiology Reviews, 2007, v. 20 n. 2, p. 243-267 How to Cite?
AbstractPandemic influenza virus has its origins in avian influenza viruses. The highly pathogenic avian influenza virus subtype H5N1 is already panzootic in poultry, with attendant economic consequences. It continues to cross species barriers to infect humans and other mammals, often with fatal outcomes. Therefore, H5N1 virus has rightly received attention as a potential pandemic threat. However, it is noted that the pandemics of 1957 and 1968 did not arise from highly pathogenic influenza viruses, and the next pandemic may well arise from a low-pathogenicity virus. The rationale for particular concern about an H5N1 pandemic is not its inevitability but its potential severity. An H5N1 pandemic is an event of low probability but one of high human health impact and poses a predicament for public health. Here, we review the ecology and evolution of highly pathogenic avian influenza H5N1 viruses, assess the pandemic risk, and address aspects of human H5N1 disease in relation to its epidemiology, clinical presentation, pathogenesis, diagnosis, and management. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/79055
ISSN
2015 Impact Factor: 16.187
2015 SCImago Journal Rankings: 8.741
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorDe Jong, MDen_HK
dc.contributor.authorGuan, Yen_HK
dc.date.accessioned2010-09-06T07:50:02Z-
dc.date.available2010-09-06T07:50:02Z-
dc.date.issued2007en_HK
dc.identifier.citationClinical Microbiology Reviews, 2007, v. 20 n. 2, p. 243-267en_HK
dc.identifier.issn0893-8512en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79055-
dc.description.abstractPandemic influenza virus has its origins in avian influenza viruses. The highly pathogenic avian influenza virus subtype H5N1 is already panzootic in poultry, with attendant economic consequences. It continues to cross species barriers to infect humans and other mammals, often with fatal outcomes. Therefore, H5N1 virus has rightly received attention as a potential pandemic threat. However, it is noted that the pandemics of 1957 and 1968 did not arise from highly pathogenic influenza viruses, and the next pandemic may well arise from a low-pathogenicity virus. The rationale for particular concern about an H5N1 pandemic is not its inevitability but its potential severity. An H5N1 pandemic is an event of low probability but one of high human health impact and poses a predicament for public health. Here, we review the ecology and evolution of highly pathogenic avian influenza H5N1 viruses, assess the pandemic risk, and address aspects of human H5N1 disease in relation to its epidemiology, clinical presentation, pathogenesis, diagnosis, and management. Copyright © 2007, American Society for Microbiology. All Rights Reserved.en_HK
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology.en_HK
dc.relation.ispartofClinical Microbiology Reviewsen_HK
dc.rightsClinical Microbiology Reviews. Copyright © American Society for Microbiology.en_HK
dc.titleAvian influenza virus (H5N1): A threat to human healthen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0893-8512&volume=April 2007&spage=243&epage=267&date=2007&atitle=Avian+Influenza+Virus+(H5N1):+a+Threat+to+Human+Healthen_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1128/CMR.00037-06en_HK
dc.identifier.pmid17428885-
dc.identifier.pmcidPMC1865597-
dc.identifier.scopuseid_2-s2.0-34248170234en_HK
dc.identifier.hkuros126490en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34248170234&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume20en_HK
dc.identifier.issue2en_HK
dc.identifier.spage243en_HK
dc.identifier.epage267en_HK
dc.identifier.isiWOS:000246058900003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridDe Jong, MD=7201366838en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.citeulike7691118-

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