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Article: Monitoring the therapy of pulmonary tuberculosis by nested polymerase chain reaction assay

TitleMonitoring the therapy of pulmonary tuberculosis by nested polymerase chain reaction assay
Authors
Issue Date1997
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jinf
Citation
Journal Of Infection, 1997, v. 34 n. 1, p. 29-33 How to Cite?
AbstractMonthly clinical and microbiological parameters (by sputum smear, culture and PCR assay), of 50 patients with documented pulmonary tuberculosis and on anti-tuberculosis therapy, were monitored over a period of 18 months. PCR converters (70%) who had PCR conversion before the sixth month of treatment did not have clinical or microbiological evidence of failure or relapse, while nine of 15 PCR persisters (30%) had clinical failure (7) and relapse (2). The PCR persisters were significantly associated with more underlying medical illnesses, high mean radiographic scores on the extent of disease involvement, previous drug treatment, initial sputum smear positivity and multi-drug resistance. Of the eight PCR persisters infected by susceptible Mycobacterium tuberculosis, all had marked residual radiographic changes despite completion of drug therapy. The findings may have important implications in the application of PCR on individualization of the duration of anti-tuberculosis therapy.
Persistent Identifierhttp://hdl.handle.net/10722/79054
ISSN
2015 Impact Factor: 4.382
2015 SCImago Journal Rankings: 2.070
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorChan, KSen_HK
dc.contributor.authorChan, CMen_HK
dc.contributor.authorHo, PLen_HK
dc.contributor.authorNg, MHen_HK
dc.date.accessioned2010-09-06T07:50:02Z-
dc.date.available2010-09-06T07:50:02Z-
dc.date.issued1997en_HK
dc.identifier.citationJournal Of Infection, 1997, v. 34 n. 1, p. 29-33en_HK
dc.identifier.issn0163-4453en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79054-
dc.description.abstractMonthly clinical and microbiological parameters (by sputum smear, culture and PCR assay), of 50 patients with documented pulmonary tuberculosis and on anti-tuberculosis therapy, were monitored over a period of 18 months. PCR converters (70%) who had PCR conversion before the sixth month of treatment did not have clinical or microbiological evidence of failure or relapse, while nine of 15 PCR persisters (30%) had clinical failure (7) and relapse (2). The PCR persisters were significantly associated with more underlying medical illnesses, high mean radiographic scores on the extent of disease involvement, previous drug treatment, initial sputum smear positivity and multi-drug resistance. Of the eight PCR persisters infected by susceptible Mycobacterium tuberculosis, all had marked residual radiographic changes despite completion of drug therapy. The findings may have important implications in the application of PCR on individualization of the duration of anti-tuberculosis therapy.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jinfen_HK
dc.relation.ispartofJournal of Infectionen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAntitubercular Agents - therapeutic useen_HK
dc.subject.meshDNA Primersen_HK
dc.subject.meshDNA Probesen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMycobacterium tuberculosis - isolation & purificationen_HK
dc.subject.meshPolymerase Chain Reactionen_HK
dc.subject.meshSputum - microbiologyen_HK
dc.subject.meshTuberculosis, Pulmonary - diagnosis - drug therapyen_HK
dc.titleMonitoring the therapy of pulmonary tuberculosis by nested polymerase chain reaction assayen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0163-4453&volume=34&spage=29&epage=33&date=1997&atitle=Monitoring+the+therapy+of+pulmonary+tuberculosis+by+nested+Polymerase+Chain+Reaction+Assayen_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0163-4453(97)80006-0en_HK
dc.identifier.pmid9120321-
dc.identifier.scopuseid_2-s2.0-0031053260en_HK
dc.identifier.hkuros27369en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031053260&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume34en_HK
dc.identifier.issue1en_HK
dc.identifier.spage29en_HK
dc.identifier.epage33en_HK
dc.identifier.isiWOS:A1997WF42000005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridChan, KS=7406031627en_HK
dc.identifier.scopusauthoridChan, CM=7404814453en_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK
dc.identifier.scopusauthoridNg, MH=7202076421en_HK

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