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Article: The study of cytokine dynamics at the operation site after mastectomy

TitleThe study of cytokine dynamics at the operation site after mastectomy
Authors
Issue Date2003
PublisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/WRR
Citation
Wound Repair And Regeneration, 2003, v. 11 n. 5, p. 326-330 How to Cite?
AbstractTwenty-nine patients, who each received modified radical mastectomy, were recruited for this study. Wounds were inspected daily for the presence of flap necrosis, infection, and seroma. Drain fluid (20 ml) was collected at 6 a.m. on postoperative days 1, 2, and 5 and the levels of interleukin (IL)-4, IL-6, tumor necrosis factor-α, and interferon-γ determined. For patients with no wound events, only IL-6 levels were elevated during the initial phase, but in the later phase the IL-6 levels dropped with a corresponding rise in tumor necrosis factor-α levels. In patients with flap necrosis, there was a sequential rise of IL-4 on day 1, IL-6 on day 2, and tumor necrosis factor-α on day 5, but only IL-4 was found to be a statistically significant factor associated with necrosis. In patients with seroma, the levels of IL-4 and interferon-γ were persistently low and were both statistically significant. To conclude, IL-6 and tumor necrosis factor-α are important in normal postoperative wound healing and IL-4 and interferon-γ may be associated with postoperative necrosis and seroma.
Persistent Identifierhttp://hdl.handle.net/10722/79040
ISSN
2015 Impact Factor: 2.628
2015 SCImago Journal Rankings: 1.149
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChow, LWCen_HK
dc.contributor.authorLoo, WTYen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorCheng, Cen_HK
dc.date.accessioned2010-09-06T07:49:51Z-
dc.date.available2010-09-06T07:49:51Z-
dc.date.issued2003en_HK
dc.identifier.citationWound Repair And Regeneration, 2003, v. 11 n. 5, p. 326-330en_HK
dc.identifier.issn1067-1927en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79040-
dc.description.abstractTwenty-nine patients, who each received modified radical mastectomy, were recruited for this study. Wounds were inspected daily for the presence of flap necrosis, infection, and seroma. Drain fluid (20 ml) was collected at 6 a.m. on postoperative days 1, 2, and 5 and the levels of interleukin (IL)-4, IL-6, tumor necrosis factor-α, and interferon-γ determined. For patients with no wound events, only IL-6 levels were elevated during the initial phase, but in the later phase the IL-6 levels dropped with a corresponding rise in tumor necrosis factor-α levels. In patients with flap necrosis, there was a sequential rise of IL-4 on day 1, IL-6 on day 2, and tumor necrosis factor-α on day 5, but only IL-4 was found to be a statistically significant factor associated with necrosis. In patients with seroma, the levels of IL-4 and interferon-γ were persistently low and were both statistically significant. To conclude, IL-6 and tumor necrosis factor-α are important in normal postoperative wound healing and IL-4 and interferon-γ may be associated with postoperative necrosis and seroma.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/WRRen_HK
dc.relation.ispartofWound Repair and Regenerationen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInterferon-gamma - metabolismen_HK
dc.subject.meshInterleukins - metabolismen_HK
dc.subject.meshKineticsen_HK
dc.subject.meshMastectomy, Modified Radicalen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.subject.meshTumor Necrosis Factor-alpha - metabolismen_HK
dc.subject.meshWound Healing - physiologyen_HK
dc.titleThe study of cytokine dynamics at the operation site after mastectomyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1067-1927&volume=11&spage=326&epage=30&date=2003&atitle=The+study+of+cytokine+dynamics+at+the+operation+site+after+mastectomyen_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1524-475X.2003.11503.xen_HK
dc.identifier.pmid12950635-
dc.identifier.scopuseid_2-s2.0-0141454707en_HK
dc.identifier.hkuros87976en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0141454707&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue5en_HK
dc.identifier.spage326en_HK
dc.identifier.epage330en_HK
dc.identifier.isiWOS:000185075600003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChow, LWC=7202532995en_HK
dc.identifier.scopusauthoridLoo, WTY=7003567474en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridCheng, C=7404797360en_HK

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