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Article: Complete genome sequence of bat coronavirus HKU2 from Chinese horseshoe bats revealed a much smaller spike gene with a different evolutionary lineage from the rest of the genome

TitleComplete genome sequence of bat coronavirus HKU2 from Chinese horseshoe bats revealed a much smaller spike gene with a different evolutionary lineage from the rest of the genome
Authors
Issue Date2007
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviro
Citation
Virology, 2007, v. 367 n. 2, p. 428-439 How to Cite?
AbstractApart from bat-SARS-CoV, we have identified a novel group 1 coronavirus, bat-CoV HKU2, in Rhinolophus sinicus (Chinese horseshoe bats). Since it has been suggested that the receptor-binding motif (RBM) of SARS-CoV may have been acquired from a group 1 coronavirus, we conducted a surveillance study and identified bat-SARS-CoV and bat-CoV HKU2 in 8.7% and 7.5% respectively of R. sinicus in Hong Kong and Guangdong. Complete genome sequencing of four strains of bat-CoV HKU2 revealed the smallest coronavirus genome (27164 nucleotides) and a unique spike protein evolutionarily distinct from the rest of the genome. This spike protein, sharing similar deletions with other group 2 coronaviruses in its C-terminus, also contained a 15-amino acid peptide homologous to a corresponding peptide within the RBM of spike protein of SARS-CoV, which was absent in other coronaviruses except bat-SARS-CoV. These suggest a common evolutionary origin in the spike protein of bat-CoV HKU2, bat-SARS-CoV, and SARS-CoV. © 2007 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/79031
ISSN
2015 Impact Factor: 3.2
2015 SCImago Journal Rankings: 1.805
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLau, SKPen_HK
dc.contributor.authorWoo, PCYen_HK
dc.contributor.authorLi, KSMen_HK
dc.contributor.authorHuang, Yen_HK
dc.contributor.authorWang, Men_HK
dc.contributor.authorLam, CSFen_HK
dc.contributor.authorXu, Hen_HK
dc.contributor.authorGuo, Ren_HK
dc.contributor.authorChan, Khen_HK
dc.contributor.authorZheng, Bjen_HK
dc.contributor.authorYuen, Kyen_HK
dc.date.accessioned2010-09-06T07:49:45Z-
dc.date.available2010-09-06T07:49:45Z-
dc.date.issued2007en_HK
dc.identifier.citationVirology, 2007, v. 367 n. 2, p. 428-439en_HK
dc.identifier.issn0042-6822en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79031-
dc.description.abstractApart from bat-SARS-CoV, we have identified a novel group 1 coronavirus, bat-CoV HKU2, in Rhinolophus sinicus (Chinese horseshoe bats). Since it has been suggested that the receptor-binding motif (RBM) of SARS-CoV may have been acquired from a group 1 coronavirus, we conducted a surveillance study and identified bat-SARS-CoV and bat-CoV HKU2 in 8.7% and 7.5% respectively of R. sinicus in Hong Kong and Guangdong. Complete genome sequencing of four strains of bat-CoV HKU2 revealed the smallest coronavirus genome (27164 nucleotides) and a unique spike protein evolutionarily distinct from the rest of the genome. This spike protein, sharing similar deletions with other group 2 coronaviruses in its C-terminus, also contained a 15-amino acid peptide homologous to a corresponding peptide within the RBM of spike protein of SARS-CoV, which was absent in other coronaviruses except bat-SARS-CoV. These suggest a common evolutionary origin in the spike protein of bat-CoV HKU2, bat-SARS-CoV, and SARS-CoV. © 2007 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviroen_HK
dc.relation.ispartofVirologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshChiroptera - virologyen_HK
dc.subject.meshCoronaviridae - classification - genetics - isolation & purificationen_HK
dc.subject.meshEvolution, Molecularen_HK
dc.subject.meshGenome, Viralen_HK
dc.subject.meshHong Kongen_HK
dc.subject.meshMembrane Glycoproteins - chemistry - geneticsen_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.subject.meshSequence Analysis, DNAen_HK
dc.subject.meshViral Envelope Proteins - chemistry - geneticsen_HK
dc.titleComplete genome sequence of bat coronavirus HKU2 from Chinese horseshoe bats revealed a much smaller spike gene with a different evolutionary lineage from the rest of the genomeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0042-6822&volume=367&issue=2&spage=428&epage=439&date=2007&atitle=Complete+genome+sequence+of+bat+coronavirus+HKU2+from+Chinese+horseshoe+bats+revealed+a+much+smaller+spike+gene+with+a+different+evolutionary+lineage+from+the+rest+of+the+genome.en_HK
dc.identifier.emailLau, SKP:skplau@hkucc.hku.hken_HK
dc.identifier.emailWoo, PCY:pcywoo@hkucc.hku.hken_HK
dc.identifier.emailZheng, Bj:bzheng@hkucc.hku.hken_HK
dc.identifier.emailYuen, Ky:kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityLau, SKP=rp00486en_HK
dc.identifier.authorityWoo, PCY=rp00430en_HK
dc.identifier.authorityZheng, Bj=rp00353en_HK
dc.identifier.authorityYuen, Ky=rp00366en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.virol.2007.06.009en_HK
dc.identifier.pmid17617433-
dc.identifier.scopuseid_2-s2.0-34848861643en_HK
dc.identifier.hkuros142911en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34848861643&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume367en_HK
dc.identifier.issue2en_HK
dc.identifier.spage428en_HK
dc.identifier.epage439en_HK
dc.identifier.isiWOS:000250162900020-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLau, SKP=7401596211en_HK
dc.identifier.scopusauthoridWoo, PCY=7201801340en_HK
dc.identifier.scopusauthoridLi, KSM=24759122500en_HK
dc.identifier.scopusauthoridHuang, Y=35597414700en_HK
dc.identifier.scopusauthoridWang, M=7406685232en_HK
dc.identifier.scopusauthoridLam, CSF=25950267400en_HK
dc.identifier.scopusauthoridXu, H=7407448207en_HK
dc.identifier.scopusauthoridGuo, R=15839273700en_HK
dc.identifier.scopusauthoridChan, Kh=7406034307en_HK
dc.identifier.scopusauthoridZheng, Bj=7201780588en_HK
dc.identifier.scopusauthoridYuen, Ky=36078079100en_HK

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