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Article: Influenza A/H5N1 virus infection in humans in Cambodia

TitleInfluenza A/H5N1 virus infection in humans in Cambodia
Authors
KeywordsAvian influenza virus
Cambodia
H5N1
Tissue tropism
Virus dissemination
Issue Date2007
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jcv
Citation
Journal Of Clinical Virology, 2007, v. 39 n. 3, p. 164-168 How to Cite?
AbstractBackground: Between January 2005 and April 2006, six patients of influenza A/H5N1 virus infection were reported in Cambodia, all with fatal outcome. Objectives: We describe the virological findings of these six H5N1 patients in association with clinical and epidemiologic findings. Study design: Broncho-alveolar lavage, nasopharyngeal, throat and rectal swabs and sera were cultured for virus isolation and viral load quantified in clinical specimens by real-time RT-PCR. We compared sequences obtained from different body sites within the same patient to detect viral quasi-species. Results: H5N1 virus strains isolated in Cambodia belong to genotype Z, clade 1 viruses. H5N1 viruses were isolated from serum and rectal swab specimens in two patients. The haemagglutinin gene sequences of the virus in different body sites did not differ. Amino acid substitutions known to be associated with a change in virus binding were not observed. Conclusion: The high frequency of virus isolation from serum and faecal swabs highlights that H5N1 is likely to be a disseminated infection in humans and this has implications for antiviral treatment, biosafety in clinical laboratories and on risks for nosocomial and human-to-human transmission. There were no tissue-specific adaptive mutations in the HA gene from viruses isolated from different organs. © 2007 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/79016
ISSN
2015 Impact Factor: 2.647
2015 SCImago Journal Rankings: 1.503
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBuchy, Pen_HK
dc.contributor.authorMardy, Sen_HK
dc.contributor.authorVong, Sen_HK
dc.contributor.authorToyoda, Ten_HK
dc.contributor.authorAubin, JTen_HK
dc.contributor.authorMiller, Men_HK
dc.contributor.authorTouch, Sen_HK
dc.contributor.authorSovann, Len_HK
dc.contributor.authorDufourcq, JBen_HK
dc.contributor.authorRichner, Ben_HK
dc.contributor.authorTu, PVen_HK
dc.contributor.authorTien, NTKen_HK
dc.contributor.authorLim, Wen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorVan der Werf, Sen_HK
dc.date.accessioned2010-09-06T07:49:34Z-
dc.date.available2010-09-06T07:49:34Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Clinical Virology, 2007, v. 39 n. 3, p. 164-168en_HK
dc.identifier.issn1386-6532en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79016-
dc.description.abstractBackground: Between January 2005 and April 2006, six patients of influenza A/H5N1 virus infection were reported in Cambodia, all with fatal outcome. Objectives: We describe the virological findings of these six H5N1 patients in association with clinical and epidemiologic findings. Study design: Broncho-alveolar lavage, nasopharyngeal, throat and rectal swabs and sera were cultured for virus isolation and viral load quantified in clinical specimens by real-time RT-PCR. We compared sequences obtained from different body sites within the same patient to detect viral quasi-species. Results: H5N1 virus strains isolated in Cambodia belong to genotype Z, clade 1 viruses. H5N1 viruses were isolated from serum and rectal swab specimens in two patients. The haemagglutinin gene sequences of the virus in different body sites did not differ. Amino acid substitutions known to be associated with a change in virus binding were not observed. Conclusion: The high frequency of virus isolation from serum and faecal swabs highlights that H5N1 is likely to be a disseminated infection in humans and this has implications for antiviral treatment, biosafety in clinical laboratories and on risks for nosocomial and human-to-human transmission. There were no tissue-specific adaptive mutations in the HA gene from viruses isolated from different organs. © 2007 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jcven_HK
dc.relation.ispartofJournal of Clinical Virologyen_HK
dc.rightsJournal of Clinical Virology. Copyright © Elsevier BV.en_HK
dc.subjectAvian influenza virusen_HK
dc.subjectCambodiaen_HK
dc.subjectH5N1en_HK
dc.subjectTissue tropismen_HK
dc.subjectVirus disseminationen_HK
dc.titleInfluenza A/H5N1 virus infection in humans in Cambodiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1386-6532&volume=39&issue=3&spage=164&epage=8&date=2007&atitle=Influenza+A/H5N1+virus+infection+in+humans+in+Cambodia.en_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jcv.2007.04.010en_HK
dc.identifier.pmid17526430en_HK
dc.identifier.scopuseid_2-s2.0-34250617533en_HK
dc.identifier.hkuros129039en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34250617533&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume39en_HK
dc.identifier.issue3en_HK
dc.identifier.spage164en_HK
dc.identifier.epage168en_HK
dc.identifier.isiWOS:000248108100002-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridBuchy, P=15019240000en_HK
dc.identifier.scopusauthoridMardy, S=6603421447en_HK
dc.identifier.scopusauthoridVong, S=6603420595en_HK
dc.identifier.scopusauthoridToyoda, T=7201723996en_HK
dc.identifier.scopusauthoridAubin, JT=7101701265en_HK
dc.identifier.scopusauthoridMiller, M=15019739200en_HK
dc.identifier.scopusauthoridTouch, S=8895193100en_HK
dc.identifier.scopusauthoridSovann, L=9242459300en_HK
dc.identifier.scopusauthoridDufourcq, JB=40161202600en_HK
dc.identifier.scopusauthoridRichner, B=6602988173en_HK
dc.identifier.scopusauthoridTu, PV=16551112700en_HK
dc.identifier.scopusauthoridTien, NTK=7006532811en_HK
dc.identifier.scopusauthoridLim, W=7202378277en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridVan der Werf, S=7005851162en_HK

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