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Article: Emergence and predominance of an H5N1 influenza variant in China

TitleEmergence and predominance of an H5N1 influenza variant in China
Authors
KeywordsInfluenza A
Molecular epidemiology
Virus evolution
Issue Date2006
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings Of The National Academy Of Sciences Of The United States Of America, 2006, v. 103 n. 45, p. 16936-16941 How to Cite?
AbstractThe development of highly pathogenic avian H5N1 influenza viruses in poultry in Eurasia accompanied with the increase in human infection in 2006 suggests that the virus has not been effectively contained and that the pandemic threat persists. Updated virological and epidemiological findings from our market surveillance in southern China demonstrate that H5N1 influenza viruses continued to be panzootic in different types of poultry. Genetic and antigenic analyses revealed the emergence and predominance of a previously uncharacterized H5W1 virus sublineage (Fujian-like) in poultry since late 2005. Viruses from this sublineage gradually replaced those multiple regional distinct sublineages and caused recent human infection in China. These viruses have already transmitted to Hong Kong, Laos, Malaysia, and Thailand, resulting in a new transmission and outbreak wave in Southeast Asia. Serological studies suggest that H5W1 seroconversion in market poultry is low and that vaccination may have facilitated the selection of the Fujian-like sublineage. The predominance of this virus over a large geographical region within a short period directly challenges current disease control measures. © 2006 by The National Academy of Sciences of the USA.
Persistent Identifierhttp://hdl.handle.net/10722/79010
ISSN
2015 Impact Factor: 9.423
2015 SCImago Journal Rankings: 6.883
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSmith, GJDen_HK
dc.contributor.authorFan, XHen_HK
dc.contributor.authorWang, Jen_HK
dc.contributor.authorLi, KSen_HK
dc.contributor.authorQin, Ken_HK
dc.contributor.authorZhang, JXen_HK
dc.contributor.authorVijaykrishna, Den_HK
dc.contributor.authorCheung, CLen_HK
dc.contributor.authorHuang, Ken_HK
dc.contributor.authorRayner, JMen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorChen, Hen_HK
dc.contributor.authorWebster, RGen_HK
dc.contributor.authorGuan, Yen_HK
dc.date.accessioned2010-09-06T07:49:30Z-
dc.date.available2010-09-06T07:49:30Z-
dc.date.issued2006en_HK
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 2006, v. 103 n. 45, p. 16936-16941en_HK
dc.identifier.issn0027-8424en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79010-
dc.description.abstractThe development of highly pathogenic avian H5N1 influenza viruses in poultry in Eurasia accompanied with the increase in human infection in 2006 suggests that the virus has not been effectively contained and that the pandemic threat persists. Updated virological and epidemiological findings from our market surveillance in southern China demonstrate that H5N1 influenza viruses continued to be panzootic in different types of poultry. Genetic and antigenic analyses revealed the emergence and predominance of a previously uncharacterized H5W1 virus sublineage (Fujian-like) in poultry since late 2005. Viruses from this sublineage gradually replaced those multiple regional distinct sublineages and caused recent human infection in China. These viruses have already transmitted to Hong Kong, Laos, Malaysia, and Thailand, resulting in a new transmission and outbreak wave in Southeast Asia. Serological studies suggest that H5W1 seroconversion in market poultry is low and that vaccination may have facilitated the selection of the Fujian-like sublineage. The predominance of this virus over a large geographical region within a short period directly challenges current disease control measures. © 2006 by The National Academy of Sciences of the USA.en_HK
dc.languageengen_HK
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_HK
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_HK
dc.subjectInfluenza Aen_HK
dc.subjectMolecular epidemiologyen_HK
dc.subjectVirus evolutionen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAntigenic Variationen_HK
dc.subject.meshAntigens, Viral - geneticsen_HK
dc.subject.meshChina - epidemiologyen_HK
dc.subject.meshEvolution, Molecularen_HK
dc.subject.meshGenetic Variationen_HK
dc.subject.meshHemagglutinin Glycoproteins, Influenza Virus - genetics - immunologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfluenza A Virus, H5N1 Subtype - genetics - immunology - isolation & purification - pathogenicityen_HK
dc.subject.meshInfluenza in Birds - epidemiology - virologyen_HK
dc.subject.meshInfluenza, Human - epidemiology - virologyen_HK
dc.subject.meshMolecular Epidemiologyen_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.subject.meshPhylogenyen_HK
dc.subject.meshPoultry - virologyen_HK
dc.subject.meshSelection, Geneticen_HK
dc.subject.meshTime Factorsen_HK
dc.titleEmergence and predominance of an H5N1 influenza variant in Chinaen_HK
dc.typeArticleen_HK
dc.identifier.emailSmith, GJD: gjsmith@hkucc1.hku.hken_HK
dc.identifier.emailZhang, JX: zhangajx@hkucc.hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailChen, H: hlchen@hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.authoritySmith, GJD=rp00444en_HK
dc.identifier.authorityZhang, JX=rp00413en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityChen, H=rp00383en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1073/pnas.0608157103en_HK
dc.identifier.pmid17075062-
dc.identifier.scopuseid_2-s2.0-33750946430en_HK
dc.identifier.hkuros124260en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33750946430&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume103en_HK
dc.identifier.issue45en_HK
dc.identifier.spage16936en_HK
dc.identifier.epage16941en_HK
dc.identifier.isiWOS:000241969500056-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSmith, GJD=8344015800en_HK
dc.identifier.scopusauthoridFan, XH=35227217200en_HK
dc.identifier.scopusauthoridWang, J=35228130300en_HK
dc.identifier.scopusauthoridLi, KS=24759122500en_HK
dc.identifier.scopusauthoridQin, K=8512090900en_HK
dc.identifier.scopusauthoridZhang, JX=12752135600en_HK
dc.identifier.scopusauthoridVijaykrishna, D=12752817700en_HK
dc.identifier.scopusauthoridCheung, CL=34975244700en_HK
dc.identifier.scopusauthoridHuang, K=44961130600en_HK
dc.identifier.scopusauthoridRayner, JM=12752258200en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridChen, H=26643315400en_HK
dc.identifier.scopusauthoridWebster, RG=36048363100en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK

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