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Article: The large 386-nt deletion in SARS-associated coronavirus: Evidence for quasispecies?

TitleThe large 386-nt deletion in SARS-associated coronavirus: Evidence for quasispecies?
Authors
Issue Date2006
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
Journal Of Infectious Diseases, 2006, v. 194 n. 6, p. 808-813 How to Cite?
AbstractThe severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is reported to have deletions of various sizes. Recently, the large 386-nucleotide deletion (L386del) comprising nucleotide positions 27719-28104 and spanning open reading frames 9-11 has been reported in the genomes of some human isolates from Hong Kong. In this study, archived specimens from 71 patients with SARS who were admitted to the New Territory East Cluster Hospitals in Hong Kong were analyzed to determine whether the L386del variant of SARS-CoV was present. There was no clear relationship between the presence of the L386del variant and SARS clinical severity as defined either by the need for intensive-care therapy and/or ventilation or by death. One patient had evidence of both the L386del variant and the wild-type variant in the same clinical specimen, supporting the idea that SARS-CoV exists as a quasispecies in some patients, although the clinical significance of these quasispecies remains unclear. © 2006 by the Infectious Diseases Society of America. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/79004
ISSN
2015 Impact Factor: 6.344
2015 SCImago Journal Rankings: 4.000
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, JWen_HK
dc.contributor.authorCheung, JLKen_HK
dc.contributor.authorChu, IMTen_HK
dc.contributor.authorSung, JJYen_HK
dc.contributor.authorPeiris, Men_HK
dc.contributor.authorChan, PKSen_HK
dc.date.accessioned2010-09-06T07:49:25Z-
dc.date.available2010-09-06T07:49:25Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of Infectious Diseases, 2006, v. 194 n. 6, p. 808-813en_HK
dc.identifier.issn0022-1899en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79004-
dc.description.abstractThe severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is reported to have deletions of various sizes. Recently, the large 386-nucleotide deletion (L386del) comprising nucleotide positions 27719-28104 and spanning open reading frames 9-11 has been reported in the genomes of some human isolates from Hong Kong. In this study, archived specimens from 71 patients with SARS who were admitted to the New Territory East Cluster Hospitals in Hong Kong were analyzed to determine whether the L386del variant of SARS-CoV was present. There was no clear relationship between the presence of the L386del variant and SARS clinical severity as defined either by the need for intensive-care therapy and/or ventilation or by death. One patient had evidence of both the L386del variant and the wild-type variant in the same clinical specimen, supporting the idea that SARS-CoV exists as a quasispecies in some patients, although the clinical significance of these quasispecies remains unclear. © 2006 by the Infectious Diseases Society of America. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org en_HK
dc.relation.ispartofJournal of Infectious Diseasesen_HK
dc.rightsJournal of Infectious Diseases. Copyright © University of Chicago Press.en_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshBase Sequenceen_HK
dc.subject.meshDisease Outbreaksen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Orderen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.subject.meshOpen Reading Frames - geneticsen_HK
dc.subject.meshPolymerase Chain Reactionen_HK
dc.subject.meshSARS Virus - classification - genetics - isolation & purification - pathogenicityen_HK
dc.subject.meshSequence Deletion - geneticsen_HK
dc.subject.meshSevere Acute Respiratory Syndrome - epidemiology - physiopathology - virologyen_HK
dc.subject.meshTime Factorsen_HK
dc.titleThe large 386-nt deletion in SARS-associated coronavirus: Evidence for quasispecies?en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-1899&volume=194&issue=6&spage=808&epage=13&date=2006&atitle=The+large+386-nt+deletion+in+SARS-associated+Coronavirus:+evidence+for+quasispecies?en_HK
dc.identifier.emailPeiris, M: malik@hkucc.hku.hken_HK
dc.identifier.authorityPeiris, M=rp00410en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1086/507044en_HK
dc.identifier.pmid16941348en_HK
dc.identifier.scopuseid_2-s2.0-33748429574en_HK
dc.identifier.hkuros124071en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33748429574&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume194en_HK
dc.identifier.issue6en_HK
dc.identifier.spage808en_HK
dc.identifier.epage813en_HK
dc.identifier.isiWOS:000240316600013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTang, JW=10341387300en_HK
dc.identifier.scopusauthoridCheung, JLK=7202072287en_HK
dc.identifier.scopusauthoridChu, IMT=7103327448en_HK
dc.identifier.scopusauthoridSung, JJY=35405352400en_HK
dc.identifier.scopusauthoridPeiris, M=7005486823en_HK
dc.identifier.scopusauthoridChan, PKS=32067487100en_HK

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