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Article: Community-associated methicillin-resistant and methicillin-sensitive Staphylococcus aureus: skin and soft tissue infections in Hong Kong

TitleCommunity-associated methicillin-resistant and methicillin-sensitive Staphylococcus aureus: skin and soft tissue infections in Hong Kong
Authors
Issue Date2008
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio
Citation
Diagnostic Microbiology And Infectious Disease, 2008, v. 61 n. 3, p. 245-250 How to Cite?
AbstractThis prospective study assessed the epidemiology of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) among patients with purulent skin and soft tissue infections (SSTIs) in Hong Kong. Among 298 patients with SSTIs, 10.4% (13/125) of all S. aureus isolates and 5% (12/241) of all abscesses were attributed to pvl-positive CA-MRSA. Overall, 77% and 69.9% of CA-MRSA and methicillin-sensitive S. aureus (MSSA) were susceptible to erythromycin, 77% and 74.8% to clindamycin, 100% and 97.1% to minocycline, and 100% and 98.1% to rifampin, respectively. Filipino ethnicity was the only clinical and epidemiologic factor significantly associated with CA-MRSA infection (odds ratio, 14.8; 95% confidence interval, 3.3-70.0; P < 0.001). Pulsed-field gel electrophoresis analysis showed that 6 CA-MRSA isolates belonged to the ST30-HKU100 clone, 5 belonged to the ST59-HKU200 clone, and 1 was singleton. Features of HKU100 isolates include SCCmec type IV, agr3, spa t019, and pan-susceptibility to non-β-lactam antibiotics. In contrast, HKU200 isolates are characterized by having SCCmec type IV or V, agr4, spa t437, and variable non-β-lactam susceptibility profiles. The major CA-MRSA spa types were shared by a minority of the MSSA. © 2008 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/78985
ISSN
2014 Impact Factor: 2.457
2014 SCImago Journal Rankings: 1.021
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, PLen_HK
dc.contributor.authorChuang, SKen_HK
dc.contributor.authorChoi, YFen_HK
dc.contributor.authorLee, RAen_HK
dc.contributor.authorLit, ACHen_HK
dc.contributor.authorNg, TKen_HK
dc.contributor.authorQue, TLen_HK
dc.contributor.authorShek, KCen_HK
dc.contributor.authorTong, HKen_HK
dc.contributor.authorTse, CWSen_HK
dc.contributor.authorTung, WKen_HK
dc.contributor.authorYung, RWHen_HK
dc.date.accessioned2010-09-06T07:49:12Z-
dc.date.available2010-09-06T07:49:12Z-
dc.date.issued2008en_HK
dc.identifier.citationDiagnostic Microbiology And Infectious Disease, 2008, v. 61 n. 3, p. 245-250en_HK
dc.identifier.issn0732-8893en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78985-
dc.description.abstractThis prospective study assessed the epidemiology of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) among patients with purulent skin and soft tissue infections (SSTIs) in Hong Kong. Among 298 patients with SSTIs, 10.4% (13/125) of all S. aureus isolates and 5% (12/241) of all abscesses were attributed to pvl-positive CA-MRSA. Overall, 77% and 69.9% of CA-MRSA and methicillin-sensitive S. aureus (MSSA) were susceptible to erythromycin, 77% and 74.8% to clindamycin, 100% and 97.1% to minocycline, and 100% and 98.1% to rifampin, respectively. Filipino ethnicity was the only clinical and epidemiologic factor significantly associated with CA-MRSA infection (odds ratio, 14.8; 95% confidence interval, 3.3-70.0; P < 0.001). Pulsed-field gel electrophoresis analysis showed that 6 CA-MRSA isolates belonged to the ST30-HKU100 clone, 5 belonged to the ST59-HKU200 clone, and 1 was singleton. Features of HKU100 isolates include SCCmec type IV, agr3, spa t019, and pan-susceptibility to non-β-lactam antibiotics. In contrast, HKU200 isolates are characterized by having SCCmec type IV or V, agr4, spa t437, and variable non-β-lactam susceptibility profiles. The major CA-MRSA spa types were shared by a minority of the MSSA. © 2008 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobioen_HK
dc.relation.ispartofDiagnostic Microbiology and Infectious Diseaseen_HK
dc.rightsDiagnostic Microbiology and Infectious Disease. Copyright © Elsevier Inc.en_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAnti-Bacterial Agents - pharmacologyen_HK
dc.subject.meshBacterial Toxins - biosynthesisen_HK
dc.subject.meshBacterial Typing Techniquesen_HK
dc.subject.meshChilden_HK
dc.subject.meshChild, Preschoolen_HK
dc.subject.meshCommunity-Acquired Infections - epidemiology - microbiologyen_HK
dc.subject.meshDNA, Bacterial - geneticsen_HK
dc.subject.meshElectrophoresis, Gel, Pulsed-Fielden_HK
dc.subject.meshEthnic Groupsen_HK
dc.subject.meshExotoxins - biosynthesisen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGenotypeen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLeukocidins - biosynthesisen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMethicillin Resistanceen_HK
dc.subject.meshMicrobial Sensitivity Testsen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshSoft Tissue Infections - epidemiology - microbiologyen_HK
dc.subject.meshStaphylococcal Infections - epidemiology - microbiologyen_HK
dc.subject.meshStaphylococcal Skin Infections - epidemiology - microbiologyen_HK
dc.subject.meshStaphylococcus aureus - classification - drug effects - genetics - isolation & purificationen_HK
dc.titleCommunity-associated methicillin-resistant and methicillin-sensitive Staphylococcus aureus: skin and soft tissue infections in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0732-8893&volume=61&spage=245&epage=50&date=2008&atitle=Community-associated+methicillin-resistant+and+methicillin-sensitive+Staphylococcus+aureus:+skin+and+soft+tissue+infections+in+Hong+Kong.en_HK
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.diagmicrobio.2007.12.015en_HK
dc.identifier.pmid18272316en_HK
dc.identifier.scopuseid_2-s2.0-45349091087en_HK
dc.identifier.hkuros165743en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-45349091087&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume61en_HK
dc.identifier.issue3en_HK
dc.identifier.spage245en_HK
dc.identifier.epage250en_HK
dc.identifier.isiWOS:000257567500001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK
dc.identifier.scopusauthoridChuang, SK=7202515853en_HK
dc.identifier.scopusauthoridChoi, YF=12806261700en_HK
dc.identifier.scopusauthoridLee, RA=7408203830en_HK
dc.identifier.scopusauthoridLit, ACH=6701801489en_HK
dc.identifier.scopusauthoridNg, TK=7402229817en_HK
dc.identifier.scopusauthoridQue, TL=7003786628en_HK
dc.identifier.scopusauthoridShek, KC=8061289800en_HK
dc.identifier.scopusauthoridTong, HK=18838906400en_HK
dc.identifier.scopusauthoridTse, CWS=7103295064en_HK
dc.identifier.scopusauthoridTung, WK=7005685767en_HK
dc.identifier.scopusauthoridYung, RWH=7005594277en_HK

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