Article: Community-associated methicillin-resistant and methicillin-sensitive Staphylococcus aureus: skin and soft tissue infections in Hong Kong

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TitleCommunity-associated methicillin-resistant and methicillin-sensitive Staphylococcus aureus: skin and soft tissue infections in Hong Kong
AuthorsHo, PL6
Chuang, SK3
Choi, YF4
Lee, RA4
Lit, ACH
Ng, TK
Que, TL2
Shek, KC2
Tong, HK5
Tse, CWS1
Tung, WK1
Yung, RWH3
Issue Date2008
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio
CitationDiagnostic Microbiology And Infectious Disease, 2008, v. 61 n. 3, p. 245-250 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.diagmicrobio.2007.12.015
AbstractThis prospective study assessed the epidemiology of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) among patients with purulent skin and soft tissue infections (SSTIs) in Hong Kong. Among 298 patients with SSTIs, 10.4% (13/125) of all S. aureus isolates and 5% (12/241) of all abscesses were attributed to pvl-positive CA-MRSA. Overall, 77% and 69.9% of CA-MRSA and methicillin-sensitive S. aureus (MSSA) were susceptible to erythromycin, 77% and 74.8% to clindamycin, 100% and 97.1% to minocycline, and 100% and 98.1% to rifampin, respectively. Filipino ethnicity was the only clinical and epidemiologic factor significantly associated with CA-MRSA infection (odds ratio, 14.8; 95% confidence interval, 3.3-70.0; P < 0.001). Pulsed-field gel electrophoresis analysis showed that 6 CA-MRSA isolates belonged to the ST30-HKU100 clone, 5 belonged to the ST59-HKU200 clone, and 1 was singleton. Features of HKU100 isolates include SCCmec type IV, agr3, spa t019, and pan-susceptibility to non-β-lactam antibiotics. In contrast, HKU200 isolates are characterized by having SCCmec type IV or V, agr4, spa t437, and variable non-β-lactam susceptibility profiles. The major CA-MRSA spa types were shared by a minority of the MSSA. © 2008 Elsevier Inc. All rights reserved.
ISSN0732-8893
2011 Impact Factor: 2.528
2011 SCImago Journal Rankings: 0.210
DOIhttp://dx.doi.org/10.1016/j.diagmicrobio.2007.12.015
ISI Accession Number IDWOS:000257567500001
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorHo, PL
dc.contributor.authorChuang, SK
dc.contributor.authorChoi, YF
dc.contributor.authorLee, RA
dc.contributor.authorLit, ACH
dc.contributor.authorNg, TK
dc.contributor.authorQue, TL
dc.contributor.authorShek, KC
dc.contributor.authorTong, HK
dc.contributor.authorTse, CWS
dc.contributor.authorTung, WK
dc.contributor.authorYung, RWH
dc.date.accessioned2010-09-06T07:49:12Z
dc.date.available2010-09-06T07:49:12Z
dc.date.issued2008
dc.description.abstractThis prospective study assessed the epidemiology of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) among patients with purulent skin and soft tissue infections (SSTIs) in Hong Kong. Among 298 patients with SSTIs, 10.4% (13/125) of all S. aureus isolates and 5% (12/241) of all abscesses were attributed to pvl-positive CA-MRSA. Overall, 77% and 69.9% of CA-MRSA and methicillin-sensitive S. aureus (MSSA) were susceptible to erythromycin, 77% and 74.8% to clindamycin, 100% and 97.1% to minocycline, and 100% and 98.1% to rifampin, respectively. Filipino ethnicity was the only clinical and epidemiologic factor significantly associated with CA-MRSA infection (odds ratio, 14.8; 95% confidence interval, 3.3-70.0; P < 0.001). Pulsed-field gel electrophoresis analysis showed that 6 CA-MRSA isolates belonged to the ST30-HKU100 clone, 5 belonged to the ST59-HKU200 clone, and 1 was singleton. Features of HKU100 isolates include SCCmec type IV, agr3, spa t019, and pan-susceptibility to non-β-lactam antibiotics. In contrast, HKU200 isolates are characterized by having SCCmec type IV or V, agr4, spa t437, and variable non-β-lactam susceptibility profiles. The major CA-MRSA spa types were shared by a minority of the MSSA. © 2008 Elsevier Inc. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationDiagnostic Microbiology And Infectious Disease, 2008, v. 61 n. 3, p. 245-250 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.diagmicrobio.2007.12.015
dc.identifier.doihttp://dx.doi.org/10.1016/j.diagmicrobio.2007.12.015
dc.identifier.epage250
dc.identifier.hkuros165743
dc.identifier.isiWOS:000257567500001
dc.identifier.issn0732-8893
2011 Impact Factor: 2.528
2011 SCImago Journal Rankings: 0.210
dc.identifier.issue3
dc.identifier.openurl
dc.identifier.pmid18272316
dc.identifier.scopuseid_2-s2.0-45349091087
dc.identifier.spage245
dc.identifier.urihttp://hdl.handle.net/10722/78985
dc.identifier.volume61
dc.languageeng
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio
dc.publisher.placeUnited States
dc.relation.ispartofDiagnostic Microbiology and Infectious Disease
dc.relation.referencesReferences in Scopus
dc.rightsDiagnostic Microbiology and Infectious Disease. Copyright © Elsevier Inc.
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshAnti-Bacterial Agents - pharmacology
dc.subject.meshBacterial Toxins - biosynthesis
dc.subject.meshBacterial Typing Techniques
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshCommunity-Acquired Infections - epidemiology - microbiology
dc.subject.meshDNA, Bacterial - genetics
dc.subject.meshElectrophoresis, Gel, Pulsed-Field
dc.subject.meshEthnic Groups
dc.subject.meshExotoxins - biosynthesis
dc.subject.meshFemale
dc.subject.meshGenotype
dc.subject.meshHong Kong - epidemiology
dc.subject.meshHumans
dc.subject.meshLeukocidins - biosynthesis
dc.subject.meshMale
dc.subject.meshMethicillin Resistance
dc.subject.meshMicrobial Sensitivity Tests
dc.subject.meshMiddle Aged
dc.subject.meshProspective Studies
dc.subject.meshSoft Tissue Infections - epidemiology - microbiology
dc.subject.meshStaphylococcal Infections - epidemiology - microbiology
dc.subject.meshStaphylococcal Skin Infections - epidemiology - microbiology
dc.subject.meshStaphylococcus aureus - classification - drug effects - genetics - isolation & purification
dc.titleCommunity-associated methicillin-resistant and methicillin-sensitive Staphylococcus aureus: skin and soft tissue infections in Hong Kong
dc.typeArticle
Author Affiliations
  1. Kwong Wah Hospital
  2. Tuen Mun Hospital
  3. Centre for Health Protection
  4. Pamela Youde Nethersole Eastern Hospital
  5. Queen Mary Hospital Hong Kong
  6. Centre of Infection