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Article: Community-associated methicillin-resistant and methicillin-sensitive Staphylococcus aureus: skin and soft tissue infections in Hong Kong
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TitleCommunity-associated methicillin-resistant and methicillin-sensitive Staphylococcus aureus: skin and soft tissue infections in Hong Kong
 
AuthorsHo, PL6
Chuang, SK3
Choi, YF4
Lee, RA4
Lit, ACH
Ng, TK
Que, TL2
Shek, KC2
Tong, HK5
Tse, CWS1
Tung, WK1
Yung, RWH3
 
Issue Date2008
 
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio
 
CitationDiagnostic Microbiology And Infectious Disease, 2008, v. 61 n. 3, p. 245-250 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.diagmicrobio.2007.12.015
 
AbstractThis prospective study assessed the epidemiology of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) among patients with purulent skin and soft tissue infections (SSTIs) in Hong Kong. Among 298 patients with SSTIs, 10.4% (13/125) of all S. aureus isolates and 5% (12/241) of all abscesses were attributed to pvl-positive CA-MRSA. Overall, 77% and 69.9% of CA-MRSA and methicillin-sensitive S. aureus (MSSA) were susceptible to erythromycin, 77% and 74.8% to clindamycin, 100% and 97.1% to minocycline, and 100% and 98.1% to rifampin, respectively. Filipino ethnicity was the only clinical and epidemiologic factor significantly associated with CA-MRSA infection (odds ratio, 14.8; 95% confidence interval, 3.3-70.0; P < 0.001). Pulsed-field gel electrophoresis analysis showed that 6 CA-MRSA isolates belonged to the ST30-HKU100 clone, 5 belonged to the ST59-HKU200 clone, and 1 was singleton. Features of HKU100 isolates include SCCmec type IV, agr3, spa t019, and pan-susceptibility to non-β-lactam antibiotics. In contrast, HKU200 isolates are characterized by having SCCmec type IV or V, agr4, spa t437, and variable non-β-lactam susceptibility profiles. The major CA-MRSA spa types were shared by a minority of the MSSA. © 2008 Elsevier Inc. All rights reserved.
 
ISSN0732-8893
2013 Impact Factor: 2.568
2013 SCImago Journal Rankings: 1.275
 
DOIhttp://dx.doi.org/10.1016/j.diagmicrobio.2007.12.015
 
ISI Accession Number IDWOS:000257567500001
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHo, PL
 
dc.contributor.authorChuang, SK
 
dc.contributor.authorChoi, YF
 
dc.contributor.authorLee, RA
 
dc.contributor.authorLit, ACH
 
dc.contributor.authorNg, TK
 
dc.contributor.authorQue, TL
 
dc.contributor.authorShek, KC
 
dc.contributor.authorTong, HK
 
dc.contributor.authorTse, CWS
 
dc.contributor.authorTung, WK
 
dc.contributor.authorYung, RWH
 
dc.date.accessioned2010-09-06T07:49:12Z
 
dc.date.available2010-09-06T07:49:12Z
 
dc.date.issued2008
 
dc.description.abstractThis prospective study assessed the epidemiology of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) among patients with purulent skin and soft tissue infections (SSTIs) in Hong Kong. Among 298 patients with SSTIs, 10.4% (13/125) of all S. aureus isolates and 5% (12/241) of all abscesses were attributed to pvl-positive CA-MRSA. Overall, 77% and 69.9% of CA-MRSA and methicillin-sensitive S. aureus (MSSA) were susceptible to erythromycin, 77% and 74.8% to clindamycin, 100% and 97.1% to minocycline, and 100% and 98.1% to rifampin, respectively. Filipino ethnicity was the only clinical and epidemiologic factor significantly associated with CA-MRSA infection (odds ratio, 14.8; 95% confidence interval, 3.3-70.0; P < 0.001). Pulsed-field gel electrophoresis analysis showed that 6 CA-MRSA isolates belonged to the ST30-HKU100 clone, 5 belonged to the ST59-HKU200 clone, and 1 was singleton. Features of HKU100 isolates include SCCmec type IV, agr3, spa t019, and pan-susceptibility to non-β-lactam antibiotics. In contrast, HKU200 isolates are characterized by having SCCmec type IV or V, agr4, spa t437, and variable non-β-lactam susceptibility profiles. The major CA-MRSA spa types were shared by a minority of the MSSA. © 2008 Elsevier Inc. All rights reserved.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationDiagnostic Microbiology And Infectious Disease, 2008, v. 61 n. 3, p. 245-250 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.diagmicrobio.2007.12.015
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.diagmicrobio.2007.12.015
 
dc.identifier.epage250
 
dc.identifier.hkuros165743
 
dc.identifier.isiWOS:000257567500001
 
dc.identifier.issn0732-8893
2013 Impact Factor: 2.568
2013 SCImago Journal Rankings: 1.275
 
dc.identifier.issue3
 
dc.identifier.openurl
 
dc.identifier.pmid18272316
 
dc.identifier.scopuseid_2-s2.0-45349091087
 
dc.identifier.spage245
 
dc.identifier.urihttp://hdl.handle.net/10722/78985
 
dc.identifier.volume61
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio
 
dc.publisher.placeUnited States
 
dc.relation.ispartofDiagnostic Microbiology and Infectious Disease
 
dc.relation.referencesReferences in Scopus
 
dc.rightsDiagnostic Microbiology and Infectious Disease. Copyright © Elsevier Inc.
 
dc.subject.meshAdolescent
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshAged, 80 and over
 
dc.subject.meshAnti-Bacterial Agents - pharmacology
 
dc.subject.meshBacterial Toxins - biosynthesis
 
dc.subject.meshBacterial Typing Techniques
 
dc.subject.meshChild
 
dc.subject.meshChild, Preschool
 
dc.subject.meshCommunity-Acquired Infections - epidemiology - microbiology
 
dc.subject.meshDNA, Bacterial - genetics
 
dc.subject.meshElectrophoresis, Gel, Pulsed-Field
 
dc.subject.meshEthnic Groups
 
dc.subject.meshExotoxins - biosynthesis
 
dc.subject.meshFemale
 
dc.subject.meshGenotype
 
dc.subject.meshHong Kong - epidemiology
 
dc.subject.meshHumans
 
dc.subject.meshLeukocidins - biosynthesis
 
dc.subject.meshMale
 
dc.subject.meshMethicillin Resistance
 
dc.subject.meshMicrobial Sensitivity Tests
 
dc.subject.meshMiddle Aged
 
dc.subject.meshProspective Studies
 
dc.subject.meshSoft Tissue Infections - epidemiology - microbiology
 
dc.subject.meshStaphylococcal Infections - epidemiology - microbiology
 
dc.subject.meshStaphylococcal Skin Infections - epidemiology - microbiology
 
dc.subject.meshStaphylococcus aureus - classification - drug effects - genetics - isolation & purification
 
dc.titleCommunity-associated methicillin-resistant and methicillin-sensitive Staphylococcus aureus: skin and soft tissue infections in Hong Kong
 
dc.typeArticle
 
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<contributor.author>Lit, ACH</contributor.author>
<contributor.author>Ng, TK</contributor.author>
<contributor.author>Que, TL</contributor.author>
<contributor.author>Shek, KC</contributor.author>
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<contributor.author>Yung, RWH</contributor.author>
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<subject.mesh>Anti-Bacterial Agents - pharmacology</subject.mesh>
<subject.mesh>Bacterial Toxins - biosynthesis</subject.mesh>
<subject.mesh>Bacterial Typing Techniques</subject.mesh>
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Author Affiliations
  1. Kwong Wah Hospital
  2. Tuen Mun Hospital
  3. Centre for Health Protection
  4. Pamela Youde Nethersole Eastern Hospital
  5. Queen Mary Hospital Hong Kong
  6. Centre of Infection