File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam

TitleEvolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam
Authors
KeywordsInfluenza A
Molecular epidemiology
Positive selection
Virus evolution
Issue Date2006
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviro
Citation
Virology, 2006, v. 350 n. 2, p. 258-268 How to Cite?
AbstractHighly pathogenic avian influenza virus H5N1 is endemic in poultry in East and Southeast Asia with disease outbreaks recently spreading to parts of central Asia, Europe and Africa. Continued interspecies transmission to humans has been reported in Vietnam, Thailand, Cambodia, Indonesia and China, causing pandemic concern. Here, we genetically characterize 82 H5N1 viruses isolated from poultry throughout Indonesia and Vietnam and 11 human isolates from southern Vietnam together with sequence data available in public databases to address questions relevant to virus introduction, endemicity and evolution. Phylogenetic analysis shows that all viruses from Indonesia form a distinct sublineage of H5N1 genotype Z viruses suggesting this outbreak likely originated from a single introduction that spread throughout the country during the past two years. Continued virus activities in Indonesia were attributed to transmission via poultry movement within the country rather than through repeated introductions by bird migration. Within Indonesia and Vietnam, H5N1 viruses have evolved over time into geographically distinct groups within each country. Molecular analysis of the H5N1 genotype Z genome shows that only the M2 and PB1-F2 genes were under positive selection, suggesting that these genes might be involved in adaptation of this virus to new hosts following interspecies transmission. At the amino acid level 12 residues were under positive selection in those genotype Z viruses, in the HA and PB1-F2 proteins. Some of these residues were more frequently observed in human isolates than in avian isolates and are related to viral antigenicity and receptor binding. Our study provides insight into the ongoing evolution of H5N1 influenza viruses that are transmitting in diverse avian species and at the interface between avian and human hosts. © 2006 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/78978
ISSN
2015 Impact Factor: 3.2
2015 SCImago Journal Rankings: 1.805
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSmith, GJDen_HK
dc.contributor.authorNaipospos, TSPen_HK
dc.contributor.authorNguyen, TDen_HK
dc.contributor.authorde Jong, MDen_HK
dc.contributor.authorVijaykrishna, Den_HK
dc.contributor.authorUsman, TBen_HK
dc.contributor.authorHassan, SSen_HK
dc.contributor.authorNguyen, TVen_HK
dc.contributor.authorDao, TVen_HK
dc.contributor.authorBui, NAen_HK
dc.contributor.authorLeung, YHCen_HK
dc.contributor.authorCheung, CLen_HK
dc.contributor.authorRayner, JMen_HK
dc.contributor.authorZhang, JXen_HK
dc.contributor.authorZhang, LJen_HK
dc.contributor.authorPoon, LLMen_HK
dc.contributor.authorLi, KSen_HK
dc.contributor.authorNguyen, VCen_HK
dc.contributor.authorHien, TTen_HK
dc.contributor.authorFarrar, Jen_HK
dc.contributor.authorWebster, RGen_HK
dc.contributor.authorChen, Hen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorGuan, Yen_HK
dc.date.accessioned2010-09-06T07:49:06Z-
dc.date.available2010-09-06T07:49:06Z-
dc.date.issued2006en_HK
dc.identifier.citationVirology, 2006, v. 350 n. 2, p. 258-268en_HK
dc.identifier.issn0042-6822en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78978-
dc.description.abstractHighly pathogenic avian influenza virus H5N1 is endemic in poultry in East and Southeast Asia with disease outbreaks recently spreading to parts of central Asia, Europe and Africa. Continued interspecies transmission to humans has been reported in Vietnam, Thailand, Cambodia, Indonesia and China, causing pandemic concern. Here, we genetically characterize 82 H5N1 viruses isolated from poultry throughout Indonesia and Vietnam and 11 human isolates from southern Vietnam together with sequence data available in public databases to address questions relevant to virus introduction, endemicity and evolution. Phylogenetic analysis shows that all viruses from Indonesia form a distinct sublineage of H5N1 genotype Z viruses suggesting this outbreak likely originated from a single introduction that spread throughout the country during the past two years. Continued virus activities in Indonesia were attributed to transmission via poultry movement within the country rather than through repeated introductions by bird migration. Within Indonesia and Vietnam, H5N1 viruses have evolved over time into geographically distinct groups within each country. Molecular analysis of the H5N1 genotype Z genome shows that only the M2 and PB1-F2 genes were under positive selection, suggesting that these genes might be involved in adaptation of this virus to new hosts following interspecies transmission. At the amino acid level 12 residues were under positive selection in those genotype Z viruses, in the HA and PB1-F2 proteins. Some of these residues were more frequently observed in human isolates than in avian isolates and are related to viral antigenicity and receptor binding. Our study provides insight into the ongoing evolution of H5N1 influenza viruses that are transmitting in diverse avian species and at the interface between avian and human hosts. © 2006 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviroen_HK
dc.relation.ispartofVirologyen_HK
dc.subjectInfluenza Aen_HK
dc.subjectMolecular epidemiologyen_HK
dc.subjectPositive selectionen_HK
dc.subjectVirus evolutionen_HK
dc.titleEvolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnamen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0042-6822&volume=350&issue=2&spage=258&epage=68&date=2006&atitle=Evolution+and+adaptation+of+H5N1+influenza+virus+in+avian+and+human+hosts+in+Indonesia+and+Vietnamen_HK
dc.identifier.emailSmith, GJD: gjsmith@hkucc1.hku.hken_HK
dc.identifier.emailLeung, YHC: cyhleung@hkucc.hku.hken_HK
dc.identifier.emailZhang, JX: zhangajx@hkucc.hku.hken_HK
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hken_HK
dc.identifier.emailChen, H: hlchen@hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.authoritySmith, GJD=rp00444en_HK
dc.identifier.authorityLeung, YHC=rp00307en_HK
dc.identifier.authorityZhang, JX=rp00413en_HK
dc.identifier.authorityPoon, LLM=rp00484en_HK
dc.identifier.authorityChen, H=rp00383en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.virol.2006.03.048en_HK
dc.identifier.scopuseid_2-s2.0-33747074407en_HK
dc.identifier.hkuros118035en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33747074407&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume350en_HK
dc.identifier.issue2en_HK
dc.identifier.spage258en_HK
dc.identifier.epage268en_HK
dc.identifier.isiWOS:000238785900002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSmith, GJD=8344015800en_HK
dc.identifier.scopusauthoridNaipospos, TSP=8722763000en_HK
dc.identifier.scopusauthoridNguyen, TD=25227791100en_HK
dc.identifier.scopusauthoridde Jong, MD=7201366838en_HK
dc.identifier.scopusauthoridVijaykrishna, D=12752817700en_HK
dc.identifier.scopusauthoridUsman, TB=25636090000en_HK
dc.identifier.scopusauthoridHassan, SS=12752589200en_HK
dc.identifier.scopusauthoridNguyen, TV=14010613100en_HK
dc.identifier.scopusauthoridDao, TV=14062933500en_HK
dc.identifier.scopusauthoridBui, NA=35919132500en_HK
dc.identifier.scopusauthoridLeung, YHC=26531438300en_HK
dc.identifier.scopusauthoridCheung, CL=34975244700en_HK
dc.identifier.scopusauthoridRayner, JM=12752258200en_HK
dc.identifier.scopusauthoridZhang, JX=12752135600en_HK
dc.identifier.scopusauthoridZhang, LJ=22137301100en_HK
dc.identifier.scopusauthoridPoon, LLM=7005441747en_HK
dc.identifier.scopusauthoridLi, KS=24759122500en_HK
dc.identifier.scopusauthoridNguyen, VC=25637323600en_HK
dc.identifier.scopusauthoridHien, TT=7005271267en_HK
dc.identifier.scopusauthoridFarrar, J=7103292979en_HK
dc.identifier.scopusauthoridWebster, RG=36048363100en_HK
dc.identifier.scopusauthoridChen, H=26643315400en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats