Article: Establishment of multiple sublineages of H5N1 influenza virus in Asia: Implications for pandemic control

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TitleEstablishment of multiple sublineages of H5N1 influenza virus in Asia: Implications for pandemic control
AuthorsChen, H2 3
Smith, GJD2 3
Li, KS3
Wang, J3
Fan, XH2
Rayner, JM2 3
Vijaykrishna, D2 3
Zhang, JX2 3
Zhang, LJ2 3
Guo, CT2
Cheung, CL2 3
Xu, KM2 3
Duan, L2 3
Huang, K2
Qin, K2 3
Leung, YHC2
Wu, WL2 3
Lu, HR2
Chen, Y1
Xia, MS1
Naipospos, TSP6
Yuen, KY2
Hassan, SS5
Bahri, S6
Nguyen, TD4
Webster, RG2 7
Peiris, JSM2 3
Guan, Y2 3
KeywordsAvian
Genetics
Human
Influenza A
Virus evolution
Issue Date2006
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
CitationProceedings Of The National Academy Of Sciences Of The United States Of America, 2006, v. 103 n. 8, p. 2845-2850 [How to Cite?]
DOI: http://dx.doi.org/10.1073/pnas.0511120103
AbstractPreparedness for a possible influenza pandemic caused by highly pathogenic avian influenza A subtype H5N1 has become a global priority. The spread of the virus to Europe and continued human infection in Southeast Asia have heightened pandemic concern. It remains unknown from where the pandemic strain may emerge; current attention is directed at Vietnam, Thailand, and, more recently, Indonesia and China. Here, we report that genetically and antigenically distinct sublineages of H5N1 virus have become established in poultry in different geographical regions of Southeast Asia, indicating the long-term endemicity of the virus, and the isolation of H5N1 virus from apparently healthy migratory birds in southern China. Our data show that H5N1 influenza virus, has continued to spread from its established source in southern China to other regions through transport of poultry and bird migration. The identification of regionally distinct sublineages contributes to the understanding of the mechanism for the perpetuation and spread of H5N1, providing information that is directly relevant to control of the source of infection in poultry. It points to the necessity of surveillance that is geographically broader than previously supposed and that includes H5N1 viruses of greater genetic and antigenic diversity. © 2006 by The National Academy of Sciences of the USA.
ISSN0027-8424
2011 Impact Factor: 9.681
2011 SCImago Journal Rankings: 1.754
DOIhttp://dx.doi.org/10.1073/pnas.0511120103
ISI Accession Number IDWOS:000235554900066
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChen, H
dc.contributor.authorSmith, GJD
dc.contributor.authorLi, KS
dc.contributor.authorWang, J
dc.contributor.authorFan, XH
dc.contributor.authorRayner, JM
dc.contributor.authorVijaykrishna, D
dc.contributor.authorZhang, JX
dc.contributor.authorZhang, LJ
dc.contributor.authorGuo, CT
dc.contributor.authorCheung, CL
dc.contributor.authorXu, KM
dc.contributor.authorDuan, L
dc.contributor.authorHuang, K
dc.contributor.authorQin, K
dc.contributor.authorLeung, YHC
dc.contributor.authorWu, WL
dc.contributor.authorLu, HR
dc.contributor.authorChen, Y
dc.contributor.authorXia, MS
dc.contributor.authorNaipospos, TSP
dc.contributor.authorYuen, KY
dc.contributor.authorHassan, SS
dc.contributor.authorBahri, S
dc.contributor.authorNguyen, TD
dc.contributor.authorWebster, RG
dc.contributor.authorPeiris, JSM
dc.contributor.authorGuan, Y
dc.date.accessioned2010-09-06T07:48:59Z
dc.date.available2010-09-06T07:48:59Z
dc.date.issued2006
dc.description.abstractPreparedness for a possible influenza pandemic caused by highly pathogenic avian influenza A subtype H5N1 has become a global priority. The spread of the virus to Europe and continued human infection in Southeast Asia have heightened pandemic concern. It remains unknown from where the pandemic strain may emerge; current attention is directed at Vietnam, Thailand, and, more recently, Indonesia and China. Here, we report that genetically and antigenically distinct sublineages of H5N1 virus have become established in poultry in different geographical regions of Southeast Asia, indicating the long-term endemicity of the virus, and the isolation of H5N1 virus from apparently healthy migratory birds in southern China. Our data show that H5N1 influenza virus, has continued to spread from its established source in southern China to other regions through transport of poultry and bird migration. The identification of regionally distinct sublineages contributes to the understanding of the mechanism for the perpetuation and spread of H5N1, providing information that is directly relevant to control of the source of infection in poultry. It points to the necessity of surveillance that is geographically broader than previously supposed and that includes H5N1 viruses of greater genetic and antigenic diversity. © 2006 by The National Academy of Sciences of the USA.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 2006, v. 103 n. 8, p. 2845-2850 [How to Cite?]
DOI: http://dx.doi.org/10.1073/pnas.0511120103
dc.identifier.doihttp://dx.doi.org/10.1073/pnas.0511120103
dc.identifier.epage2850
dc.identifier.hkuros120654
dc.identifier.isiWOS:000235554900066
dc.identifier.issn0027-8424
2011 Impact Factor: 9.681
2011 SCImago Journal Rankings: 1.754
dc.identifier.issue8
dc.identifier.pmid16473931
dc.identifier.scopuseid_2-s2.0-33644526903
dc.identifier.spage2845
dc.identifier.urihttp://hdl.handle.net/10722/78967
dc.identifier.volume103
dc.languageeng
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
dc.publisher.placeUnited States
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of America
dc.relation.referencesReferences in Scopus
dc.subject.meshAnimals
dc.subject.meshAsia, Southeastern
dc.subject.meshBase Sequence
dc.subject.meshDisease Outbreaks - prevention & control
dc.subject.meshDucks - virology
dc.subject.meshHumans
dc.subject.meshInfluenza A Virus, H5N1 Subtype - isolation & purification - pathogenicity
dc.subject.meshInfluenza in Birds - epidemiology - transmission - virology
dc.subject.meshInfluenza, Human - epidemiology - prevention & control - transmission - virology
dc.subject.meshMolecular Sequence Data
dc.subject.meshPhylogeny
dc.subject.meshSerotyping
dc.subjectAvian
dc.subjectGenetics
dc.subjectHuman
dc.subjectInfluenza A
dc.subjectVirus evolution
dc.titleEstablishment of multiple sublineages of H5N1 influenza virus in Asia: Implications for pandemic control
dc.typeArticle
Author Affiliations
  1. Xiamen University
  2. The University of Hong Kong
  3. Shantou University, Medical College (SUMC)
  4. National Institute of Veterinary Research Hanoi
  5. Veterinary Research Institute - Ipoh
  6. Ministry of Agriculture, Indonesia
  7. St. Jude Children Research Hospital