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Article: Establishment of multiple sublineages of H5N1 influenza virus in Asia: Implications for pandemic control

TitleEstablishment of multiple sublineages of H5N1 influenza virus in Asia: Implications for pandemic control
Authors
KeywordsAvian
Genetics
Human
Influenza A
Virus evolution
Issue Date2006
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings Of The National Academy Of Sciences Of The United States Of America, 2006, v. 103 n. 8, p. 2845-2850 How to Cite?
Abstract
Preparedness for a possible influenza pandemic caused by highly pathogenic avian influenza A subtype H5N1 has become a global priority. The spread of the virus to Europe and continued human infection in Southeast Asia have heightened pandemic concern. It remains unknown from where the pandemic strain may emerge; current attention is directed at Vietnam, Thailand, and, more recently, Indonesia and China. Here, we report that genetically and antigenically distinct sublineages of H5N1 virus have become established in poultry in different geographical regions of Southeast Asia, indicating the long-term endemicity of the virus, and the isolation of H5N1 virus from apparently healthy migratory birds in southern China. Our data show that H5N1 influenza virus, has continued to spread from its established source in southern China to other regions through transport of poultry and bird migration. The identification of regionally distinct sublineages contributes to the understanding of the mechanism for the perpetuation and spread of H5N1, providing information that is directly relevant to control of the source of infection in poultry. It points to the necessity of surveillance that is geographically broader than previously supposed and that includes H5N1 viruses of greater genetic and antigenic diversity. © 2006 by The National Academy of Sciences of the USA.
Persistent Identifierhttp://hdl.handle.net/10722/78967
ISSN
2013 Impact Factor: 9.809
ISI Accession Number ID
References

 

Author Affiliations
  1. Xiamen University
  2. The University of Hong Kong
  3. National Institute of Veterinary Research Hanoi
  4. Shantou University, Medical College (SUMC)
  5. Veterinary Research Institute - Ipoh
  6. Ministry of Agriculture, Indonesia
  7. St. Jude Children Research Hospital
DC FieldValueLanguage
dc.contributor.authorChen, Hen_HK
dc.contributor.authorSmith, GJDen_HK
dc.contributor.authorLi, KSen_HK
dc.contributor.authorWang, Jen_HK
dc.contributor.authorFan, XHen_HK
dc.contributor.authorRayner, JMen_HK
dc.contributor.authorVijaykrishna, Den_HK
dc.contributor.authorZhang, JXen_HK
dc.contributor.authorZhang, LJen_HK
dc.contributor.authorGuo, CTen_HK
dc.contributor.authorCheung, CLen_HK
dc.contributor.authorXu, KMen_HK
dc.contributor.authorDuan, Len_HK
dc.contributor.authorHuang, Ken_HK
dc.contributor.authorQin, Ken_HK
dc.contributor.authorLeung, YHCen_HK
dc.contributor.authorWu, WLen_HK
dc.contributor.authorLu, HRen_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorXia, MSen_HK
dc.contributor.authorNaipospos, TSPen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorHassan, SSen_HK
dc.contributor.authorBahri, Sen_HK
dc.contributor.authorNguyen, TDen_HK
dc.contributor.authorWebster, RGen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorGuan, Yen_HK
dc.date.accessioned2010-09-06T07:48:59Z-
dc.date.available2010-09-06T07:48:59Z-
dc.date.issued2006en_HK
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 2006, v. 103 n. 8, p. 2845-2850en_HK
dc.identifier.issn0027-8424en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78967-
dc.description.abstractPreparedness for a possible influenza pandemic caused by highly pathogenic avian influenza A subtype H5N1 has become a global priority. The spread of the virus to Europe and continued human infection in Southeast Asia have heightened pandemic concern. It remains unknown from where the pandemic strain may emerge; current attention is directed at Vietnam, Thailand, and, more recently, Indonesia and China. Here, we report that genetically and antigenically distinct sublineages of H5N1 virus have become established in poultry in different geographical regions of Southeast Asia, indicating the long-term endemicity of the virus, and the isolation of H5N1 virus from apparently healthy migratory birds in southern China. Our data show that H5N1 influenza virus, has continued to spread from its established source in southern China to other regions through transport of poultry and bird migration. The identification of regionally distinct sublineages contributes to the understanding of the mechanism for the perpetuation and spread of H5N1, providing information that is directly relevant to control of the source of infection in poultry. It points to the necessity of surveillance that is geographically broader than previously supposed and that includes H5N1 viruses of greater genetic and antigenic diversity. © 2006 by The National Academy of Sciences of the USA.en_HK
dc.languageengen_HK
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_HK
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_HK
dc.subjectAvianen_HK
dc.subjectGeneticsen_HK
dc.subjectHumanen_HK
dc.subjectInfluenza Aen_HK
dc.subjectVirus evolutionen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAsia, Southeasternen_HK
dc.subject.meshBase Sequenceen_HK
dc.subject.meshDisease Outbreaks - prevention & controlen_HK
dc.subject.meshDucks - virologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfluenza A Virus, H5N1 Subtype - isolation & purification - pathogenicityen_HK
dc.subject.meshInfluenza in Birds - epidemiology - transmission - virologyen_HK
dc.subject.meshInfluenza, Human - epidemiology - prevention & control - transmission - virologyen_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.subject.meshPhylogenyen_HK
dc.subject.meshSerotypingen_HK
dc.titleEstablishment of multiple sublineages of H5N1 influenza virus in Asia: Implications for pandemic controlen_HK
dc.typeArticleen_HK
dc.identifier.emailChen, H: hlchen@hku.hken_HK
dc.identifier.emailSmith, GJD: gjsmith@hkucc1.hku.hken_HK
dc.identifier.emailZhang, JX: zhangajx@hkucc.hku.hken_HK
dc.identifier.emailLeung, YHC: cyhleung@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.authorityChen, H=rp00383en_HK
dc.identifier.authoritySmith, GJD=rp00444en_HK
dc.identifier.authorityZhang, JX=rp00413en_HK
dc.identifier.authorityLeung, YHC=rp00307en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1073/pnas.0511120103en_HK
dc.identifier.pmid16473931en_HK
dc.identifier.scopuseid_2-s2.0-33644526903en_HK
dc.identifier.hkuros120654en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33644526903&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume103en_HK
dc.identifier.issue8en_HK
dc.identifier.spage2845en_HK
dc.identifier.epage2850en_HK
dc.identifier.isiWOS:000235554900066-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChen, H=26643315400en_HK
dc.identifier.scopusauthoridSmith, GJD=8344015800en_HK
dc.identifier.scopusauthoridLi, KS=36072420200en_HK
dc.identifier.scopusauthoridWang, J=35228130300en_HK
dc.identifier.scopusauthoridFan, XH=35227217200en_HK
dc.identifier.scopusauthoridRayner, JM=12752258200en_HK
dc.identifier.scopusauthoridVijaykrishna, D=12752817700en_HK
dc.identifier.scopusauthoridZhang, JX=12752135600en_HK
dc.identifier.scopusauthoridZhang, LJ=22137301100en_HK
dc.identifier.scopusauthoridGuo, CT=7402496810en_HK
dc.identifier.scopusauthoridCheung, CL=34975244700en_HK
dc.identifier.scopusauthoridXu, KM=35228266300en_HK
dc.identifier.scopusauthoridDuan, L=7201932765en_HK
dc.identifier.scopusauthoridHuang, K=44961130600en_HK
dc.identifier.scopusauthoridQin, K=8512090900en_HK
dc.identifier.scopusauthoridLeung, YHC=26531438300en_HK
dc.identifier.scopusauthoridWu, WL=16835478800en_HK
dc.identifier.scopusauthoridLu, HR=35314890400en_HK
dc.identifier.scopusauthoridChen, Y=10739973700en_HK
dc.identifier.scopusauthoridXia, MS=35315212500en_HK
dc.identifier.scopusauthoridNaipospos, TSP=8722763000en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridHassan, SS=12752589200en_HK
dc.identifier.scopusauthoridBahri, S=35314502300en_HK
dc.identifier.scopusauthoridNguyen, TD=25227791100en_HK
dc.identifier.scopusauthoridWebster, RG=36048363100en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK

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