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Article: Lack of evidence of active lytic replication of Epstein-Barr and cytomegaloviruses in patients with systemic lupus erythematosus

TitleLack of evidence of active lytic replication of Epstein-Barr and cytomegaloviruses in patients with systemic lupus erythematosus
Authors
Issue Date1998
PublisherChinese Medical Association. The Journal's web site is located at http://www.cmj.org/
Citation
Chinese Medical Journal, 1998, v. 111 n. 7, p. 660-665 How to Cite?
AbstractObjectives Systemic lupus erythematosus (SLE) is a multifactorial disease. Environmental factors such as viral infection(s) have been proposed as pathaetioiogical factors. There are particular interests in studying lymphotropic viruses such as the Epstein-Barr virus (EBV) and cytomegalovirus (CMV). Although previous case reports and in vitro studies suggested that they may have a role, there is no direct evidence that onset of SLE or disease exacerbation is associated with active infection by these viruses. Using the very sensitive polymerase chain reaction (PCR) technique, we tried to find out evidence of active replication of these viruses in patients with SLE. Methods Thirty-four patients with SLE were compared with matched normal controls. Eleven patients were newly diagnosed to have SLE and 18 of the 34 patients had active disease as determined by a SLE Disease Activity Index (SLEDAI) score of ≥ 10 at the time of study. Results Our results showed no evidence of active replication or reactivation of EBV in the leucocytes amongst the newly diagnosed SLE patients, established SLE patients, patients with SLEDAI ≥ 10, patients with SLEDAI < 10, and control subjects. There was no evidence of CMV infection in any of the subjects studied. The IgG and IgA responses against EBV early antigen (EA) and viral capsid antigen (VGA) were also studied. The IgG and IgA responses against VGA of EBV were increased in patients with SLE when compared with controls. However, there were no differences in these responses among different subgroups of patients. The mechanism of these responses was not apparent but may represent non-specific hyperimmune responses in these patients. There were no differences in the titre of IgG and IgA against EBV EA between the patient groups and controls. Conclusion There is no direct evidence that either EBV or CMV plays a direct role in the onset and/or exacerbation of SLE.
Persistent Identifierhttp://hdl.handle.net/10722/78945
ISSN
2015 Impact Factor: 0.957
2015 SCImago Journal Rankings: 0.428
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLan, CSen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorWong, RWSen_HK
dc.date.accessioned2010-09-06T07:48:43Z-
dc.date.available2010-09-06T07:48:43Z-
dc.date.issued1998en_HK
dc.identifier.citationChinese Medical Journal, 1998, v. 111 n. 7, p. 660-665en_HK
dc.identifier.issn0366-6999en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78945-
dc.description.abstractObjectives Systemic lupus erythematosus (SLE) is a multifactorial disease. Environmental factors such as viral infection(s) have been proposed as pathaetioiogical factors. There are particular interests in studying lymphotropic viruses such as the Epstein-Barr virus (EBV) and cytomegalovirus (CMV). Although previous case reports and in vitro studies suggested that they may have a role, there is no direct evidence that onset of SLE or disease exacerbation is associated with active infection by these viruses. Using the very sensitive polymerase chain reaction (PCR) technique, we tried to find out evidence of active replication of these viruses in patients with SLE. Methods Thirty-four patients with SLE were compared with matched normal controls. Eleven patients were newly diagnosed to have SLE and 18 of the 34 patients had active disease as determined by a SLE Disease Activity Index (SLEDAI) score of ≥ 10 at the time of study. Results Our results showed no evidence of active replication or reactivation of EBV in the leucocytes amongst the newly diagnosed SLE patients, established SLE patients, patients with SLEDAI ≥ 10, patients with SLEDAI < 10, and control subjects. There was no evidence of CMV infection in any of the subjects studied. The IgG and IgA responses against EBV early antigen (EA) and viral capsid antigen (VGA) were also studied. The IgG and IgA responses against VGA of EBV were increased in patients with SLE when compared with controls. However, there were no differences in these responses among different subgroups of patients. The mechanism of these responses was not apparent but may represent non-specific hyperimmune responses in these patients. There were no differences in the titre of IgG and IgA against EBV EA between the patient groups and controls. Conclusion There is no direct evidence that either EBV or CMV plays a direct role in the onset and/or exacerbation of SLE.en_HK
dc.languageengen_HK
dc.publisherChinese Medical Association. The Journal's web site is located at http://www.cmj.org/en_HK
dc.relation.ispartofChinese Medical Journalen_HK
dc.subject.meshAntibodies, Viral - blooden_HK
dc.subject.meshAntigens, Viral - blooden_HK
dc.subject.meshCapsid Proteinsen_HK
dc.subject.meshCytomegalovirus - immunology - isolation & purificationen_HK
dc.subject.meshHerpesvirus 4, Human - immunology - isolation & purification - physiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLupus Erythematosus, Systemic - virologyen_HK
dc.subject.meshVirus Replicationen_HK
dc.titleLack of evidence of active lytic replication of Epstein-Barr and cytomegaloviruses in patients with systemic lupus erythematosusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0366-6999&volume=111&spage=660&epage=665&date=1998&atitle=Lack+of+evidence+of+active+lytic+replication+of+Epstein-Barr+and+cytomegaloviruses+in+patients+with+systemic+lupus+erythematosusen_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid11245059-
dc.identifier.scopuseid_2-s2.0-2442496566en_HK
dc.identifier.hkuros37834en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2442496566&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume111en_HK
dc.identifier.issue7en_HK
dc.identifier.spage660en_HK
dc.identifier.epage665en_HK
dc.identifier.isiWOS:000075201000021-
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridLan, CS=7202620975en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridChan, KH=7406034307en_HK
dc.identifier.scopusauthoridWong, RWS=34875928200en_HK

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