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Article: Epidemiology and genetic diversity of methicillin-resistant Staphylococcus aureus strains in residential care homes for elderly persons in Hong Kong

TitleEpidemiology and genetic diversity of methicillin-resistant Staphylococcus aureus strains in residential care homes for elderly persons in Hong Kong
Authors
Issue Date2007
PublisherUniversity of Chicago Press. The Journal's web site is located at http://www.journals.uchicago.edu/ICHE/home.html
Citation
Infection Control And Hospital Epidemiology, 2007, v. 28 n. 6, p. 671-678 How to Cite?
AbstractOBJECTIVE. To determine the prevalence and molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) strains among residents in residential care homes for the elderly in Hong Kong. DESIGN. Cross-sectional and descriptive study. PARTICIPANTS. A total of 949 residents in 13 residential care homes for elderly persons in Hong Kong in January 2005. METHODS. MRSA colonization was assessed by culture of swab specimens from anterior nares and active skin lesions. Characteristics of residents were obtained by a standard questionnaire. All MRSA isolates were analyzed by polymerase chain reaction for their staphylococcal cassette chromosome (SCC) mec content and were typed by pulsed-field gel electrophoresis (PFGE) and multilocus sequencing. RESULTS. MRSA colonization was detected in 27 residents (2.8%). No MRSA was found in 2 facilities. The rate of MRSA carriage in the other 11 facilities ranged from 1.9% to 4.2%. In univariate analysis, functional immobility (odds ratio [OR], 1.4), history of hospital admission (OR, 2.3), and the use of nebulized medication (OR, 5.4) were significantly associated with MRSA colonization. The isolates had 11 unique antibiograms, with 14 isolates susceptible to all but 1 or 2 of the non-β-lactam antimicrobial agents tested. The isolates exhibited SCCmec types I (1 isolate), II (2 isolates), III (1 isolate), IV/IVA (10 isolates), and V (13 isolates). No isolates had the Panton-Valentine leukocidin genes. PFGE analysis clustered all except 1 isolate into 7 PFGE types, designated HKU10 to HKU70. Between 1 and 4 unique PFGE types were found in the individual residential care facilities. CONCLUSION. This study documented the emergence of SCCmec types IV and V among genetically diverse MRSA strains in residential care homes for elderly persons in Hong Kong. © 2007 by The Society for Healthcare Epidemiology of America. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/78937
ISSN
2015 Impact Factor: 3.669
2015 SCImago Journal Rankings: 1.985
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, PLen_HK
dc.contributor.authorWang, TKFen_HK
dc.contributor.authorChing, Pen_HK
dc.contributor.authorMak, GCen_HK
dc.contributor.authorLai, Een_HK
dc.contributor.authorYam, WCen_HK
dc.contributor.authorSeto, WHen_HK
dc.date.accessioned2010-09-06T07:48:37Z-
dc.date.available2010-09-06T07:48:37Z-
dc.date.issued2007en_HK
dc.identifier.citationInfection Control And Hospital Epidemiology, 2007, v. 28 n. 6, p. 671-678en_HK
dc.identifier.issn0899-823Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/78937-
dc.description.abstractOBJECTIVE. To determine the prevalence and molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) strains among residents in residential care homes for the elderly in Hong Kong. DESIGN. Cross-sectional and descriptive study. PARTICIPANTS. A total of 949 residents in 13 residential care homes for elderly persons in Hong Kong in January 2005. METHODS. MRSA colonization was assessed by culture of swab specimens from anterior nares and active skin lesions. Characteristics of residents were obtained by a standard questionnaire. All MRSA isolates were analyzed by polymerase chain reaction for their staphylococcal cassette chromosome (SCC) mec content and were typed by pulsed-field gel electrophoresis (PFGE) and multilocus sequencing. RESULTS. MRSA colonization was detected in 27 residents (2.8%). No MRSA was found in 2 facilities. The rate of MRSA carriage in the other 11 facilities ranged from 1.9% to 4.2%. In univariate analysis, functional immobility (odds ratio [OR], 1.4), history of hospital admission (OR, 2.3), and the use of nebulized medication (OR, 5.4) were significantly associated with MRSA colonization. The isolates had 11 unique antibiograms, with 14 isolates susceptible to all but 1 or 2 of the non-β-lactam antimicrobial agents tested. The isolates exhibited SCCmec types I (1 isolate), II (2 isolates), III (1 isolate), IV/IVA (10 isolates), and V (13 isolates). No isolates had the Panton-Valentine leukocidin genes. PFGE analysis clustered all except 1 isolate into 7 PFGE types, designated HKU10 to HKU70. Between 1 and 4 unique PFGE types were found in the individual residential care facilities. CONCLUSION. This study documented the emergence of SCCmec types IV and V among genetically diverse MRSA strains in residential care homes for elderly persons in Hong Kong. © 2007 by The Society for Healthcare Epidemiology of America. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherUniversity of Chicago Press. The Journal's web site is located at http://www.journals.uchicago.edu/ICHE/home.htmlen_HK
dc.relation.ispartofInfection Control and Hospital Epidemiologyen_HK
dc.rightsInfection Control & Hospital Epidemiology. Copyright © University of Chicago Press.en_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshCross-Sectional Studiesen_HK
dc.subject.meshDNA Primersen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHomes for the Ageden_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMethicillin - pharmacologyen_HK
dc.subject.meshMethicillin Resistance - geneticsen_HK
dc.subject.meshNasal Cavity - microbiologyen_HK
dc.subject.meshPolymerase Chain Reactionen_HK
dc.subject.meshQuestionnairesen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshSkin - microbiologyen_HK
dc.subject.meshStaphylococcal Infections - drug therapy - epidemiology - microbiologyen_HK
dc.subject.meshStaphylococcus aureus - drug effects - genetics - isolation & purificationen_HK
dc.titleEpidemiology and genetic diversity of methicillin-resistant Staphylococcus aureus strains in residential care homes for elderly persons in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0899-823X&volume=28&issue=6&spage=671&epage=8&date=2007&atitle=Epidemiology+and+genetic+diversity+of+methicillin-resistant+Staphylococcus+aureus+strains+in+residential+care+homes+for+elderly+persons+in+Hong+Kongen_HK
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_HK
dc.identifier.emailYam, WC:wcyam@hkucc.hku.hken_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.identifier.authorityYam, WC=rp00313en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1086/517951en_HK
dc.identifier.pmid17520539-
dc.identifier.scopuseid_2-s2.0-34250788515en_HK
dc.identifier.hkuros136481en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34250788515&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue6en_HK
dc.identifier.spage671en_HK
dc.identifier.epage678en_HK
dc.identifier.isiWOS:000249121300006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK
dc.identifier.scopusauthoridWang, TKF=7405566621en_HK
dc.identifier.scopusauthoridChing, P=7005847968en_HK
dc.identifier.scopusauthoridMak, GC=8883252800en_HK
dc.identifier.scopusauthoridLai, E=8238477100en_HK
dc.identifier.scopusauthoridYam, WC=7004281720en_HK
dc.identifier.scopusauthoridSeto, WH=7005799377en_HK

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