File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Effects of single nucleotide polymorphisms in the RANTES promoter region in healthy and HIV-infected indigenous Chinese

TitleEffects of single nucleotide polymorphisms in the RANTES promoter region in healthy and HIV-infected indigenous Chinese
Authors
Issue Date2004
PublisherBlackwell Publishing Ltd.
Citation
European Journal Of Immunogenetics, 2004, v. 31 n. 4, p. 179-183 How to Cite?
AbstractWe determined the occurrence of the single nucleotide polymorphisms (SNPs) -403A/G and -28C/G in the promoter region of RANTES in 1082 Chinese blood donors from northern and southern China and 249 HIV patients from southern China. Compared to healthy adults, Chinese AIDS patients had a significantly higher frequency of the -403G allele and haplotype I, -403G/-28C (P < 0.05), and a lower frequency of the -403A/A genotype (P < 0.01). Symptomatic patients had a higher frequency of the -28G allele and a lower frequency of the -28C/C genotype (P ≤ 0.01). The plasma RANTES level was significantly lower in blood donors homozygous for haplotype I than in those who were homozygous for haplotypes II and III (P < 0.05). The frequency of the -403G allele was found to be higher in Chinese than in indigenous Africans, but lower than in Caucasians, Hispanics, and African Americans. The frequency of the -28G allele was comparable in Chinese and Japanese; this allele is rare in other ethnic groups. Results suggest that -403G may be associated with increased susceptibility to HIV infection, while -28G may be associated with advanced disease progression. The impact of SNPs on HIV infection appears to be unique in Chinese.
Persistent Identifierhttp://hdl.handle.net/10722/78928
ISSN
2006 Impact Factor: 1.9
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhao, XYen_HK
dc.contributor.authorLee, SSen_HK
dc.contributor.authorWong, KHen_HK
dc.contributor.authorChan, KCWen_HK
dc.contributor.authorMa, Sen_HK
dc.contributor.authorYam, WCen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorNg, MHen_HK
dc.contributor.authorZheng, BJen_HK
dc.date.accessioned2010-09-06T07:48:30Z-
dc.date.available2010-09-06T07:48:30Z-
dc.date.issued2004en_HK
dc.identifier.citationEuropean Journal Of Immunogenetics, 2004, v. 31 n. 4, p. 179-183en_HK
dc.identifier.issn0960-7420en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78928-
dc.description.abstractWe determined the occurrence of the single nucleotide polymorphisms (SNPs) -403A/G and -28C/G in the promoter region of RANTES in 1082 Chinese blood donors from northern and southern China and 249 HIV patients from southern China. Compared to healthy adults, Chinese AIDS patients had a significantly higher frequency of the -403G allele and haplotype I, -403G/-28C (P < 0.05), and a lower frequency of the -403A/A genotype (P < 0.01). Symptomatic patients had a higher frequency of the -28G allele and a lower frequency of the -28C/C genotype (P ≤ 0.01). The plasma RANTES level was significantly lower in blood donors homozygous for haplotype I than in those who were homozygous for haplotypes II and III (P < 0.05). The frequency of the -403G allele was found to be higher in Chinese than in indigenous Africans, but lower than in Caucasians, Hispanics, and African Americans. The frequency of the -28G allele was comparable in Chinese and Japanese; this allele is rare in other ethnic groups. Results suggest that -403G may be associated with increased susceptibility to HIV infection, while -28G may be associated with advanced disease progression. The impact of SNPs on HIV infection appears to be unique in Chinese.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd.en_HK
dc.relation.ispartofEuropean Journal of Immunogeneticsen_HK
dc.rightsInternational Journal of Immunogenetics (Online Edition). Copyright © Blackwell Publishing Ltd.en_HK
dc.subject.meshChemokine CCL5 - blood - geneticsen_HK
dc.subject.meshChinaen_HK
dc.subject.meshGenetic Predisposition to Diseaseen_HK
dc.subject.meshGenotypeen_HK
dc.subject.meshHIV - metabolismen_HK
dc.subject.meshHIV Infections - genetics - metabolismen_HK
dc.subject.meshHaplotypesen_HK
dc.subject.meshHomozygoteen_HK
dc.subject.meshHumansen_HK
dc.subject.meshPolymorphism, Single Nucleotideen_HK
dc.subject.meshPromoter Regions, Geneticen_HK
dc.titleEffects of single nucleotide polymorphisms in the RANTES promoter region in healthy and HIV-infected indigenous Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1744-313X&volume=31&issue=4&spage=179&epage=83&date=2004&atitle=Effects+of+single+nucleotide+polymorphisms+in+the+RANTES+promoter+region+in+healthy+and+HIV-infected+indigenous+Chinese.en_HK
dc.identifier.emailYam, WC:wcyam@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.emailZheng, BJ:bzheng@hkucc.hku.hken_HK
dc.identifier.authorityYam, WC=rp00313en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityZheng, BJ=rp00353en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1365-2370.2004.00466.xen_HK
dc.identifier.pmid15265023-
dc.identifier.scopuseid_2-s2.0-3943075742en_HK
dc.identifier.hkuros94858en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3943075742&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume31en_HK
dc.identifier.issue4en_HK
dc.identifier.spage179en_HK
dc.identifier.epage183en_HK
dc.identifier.isiWOS:000222715700005-
dc.identifier.scopusauthoridZhao, XY=7407577215en_HK
dc.identifier.scopusauthoridLee, SS=7601394467en_HK
dc.identifier.scopusauthoridWong, KH=7404758411en_HK
dc.identifier.scopusauthoridChan, KCW=35097079800en_HK
dc.identifier.scopusauthoridMa, S=35215973500en_HK
dc.identifier.scopusauthoridYam, WC=7004281720en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridNg, MH=7202076421en_HK
dc.identifier.scopusauthoridZheng, BJ=7201780588en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats