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Article: A prospective case control study of the association of Gianotti-Crosti syndrome with human herpesvirus 6 and human herpesvirus 7 infections

TitleA prospective case control study of the association of Gianotti-Crosti syndrome with human herpesvirus 6 and human herpesvirus 7 infections
Authors
Issue Date2002
PublisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PDE
Citation
Pediatric Dermatology, 2002, v. 19 n. 6, p. 492-497 How to Cite?
AbstractGianotti-Crosti syndrome (GCS) is known to be associated with hepatitis B and Epstein-Barr virus (EBV) infections. Apart from a single case report based on serology alone, there are no published data on an association between GCS and human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) primary infections or reactivations. Our aim was to investigate the association between GCS and HHV-6 and HHV-7 infections. Ten patients diagnosed with GCS at a primary care practice over an 18-month period were recruited. Controls were age- and sex-matched patients with unrelated symptoms requiring venepuncture for other indications. Blood specimens were collected from patients and controls at presentation, and from patients 4 weeks later. Virologic evidence of HHV-6 and HHV-7 infection was sought in peripheral blood leukocytes and plasma using polymerase chain reaction (PCR) for viral DNA, reverse transcriptase polymerase chain reaction (RT-PCR) for HHV-6 U91 mRNA transcripts, and serology. Serology for EBV and hepatitis B virus was done. In contrast to the 10 controls, 2 patients (both infants) with clinically diagnosed GCS had evidence of active HHV-6 infection. This was demonstrated by detection of viral DNA in the absence of antibody in the acute plasma specimens and HHV-6 DNA viral loads of more than 5.3 log10 genome copies/5 μl in the whole blood specimens, a profile previously shown to be diagnostic of recent primary HHV-6 infection. None of the patients had evidence of recent EBV or hepatitis B infection. We conclude that primary HHV-6 infection may be associated with GCS in some infants.
Persistent Identifierhttp://hdl.handle.net/10722/78927
ISSN
2015 Impact Factor: 1.163
2015 SCImago Journal Rankings: 0.633
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChuh, AATen_HK
dc.contributor.authorChan, HHLen_HK
dc.contributor.authorChiu, SSSen_HK
dc.contributor.authorNg, HYen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.date.accessioned2010-09-06T07:48:29Z-
dc.date.available2010-09-06T07:48:29Z-
dc.date.issued2002en_HK
dc.identifier.citationPediatric Dermatology, 2002, v. 19 n. 6, p. 492-497en_HK
dc.identifier.issn0736-8046en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78927-
dc.description.abstractGianotti-Crosti syndrome (GCS) is known to be associated with hepatitis B and Epstein-Barr virus (EBV) infections. Apart from a single case report based on serology alone, there are no published data on an association between GCS and human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) primary infections or reactivations. Our aim was to investigate the association between GCS and HHV-6 and HHV-7 infections. Ten patients diagnosed with GCS at a primary care practice over an 18-month period were recruited. Controls were age- and sex-matched patients with unrelated symptoms requiring venepuncture for other indications. Blood specimens were collected from patients and controls at presentation, and from patients 4 weeks later. Virologic evidence of HHV-6 and HHV-7 infection was sought in peripheral blood leukocytes and plasma using polymerase chain reaction (PCR) for viral DNA, reverse transcriptase polymerase chain reaction (RT-PCR) for HHV-6 U91 mRNA transcripts, and serology. Serology for EBV and hepatitis B virus was done. In contrast to the 10 controls, 2 patients (both infants) with clinically diagnosed GCS had evidence of active HHV-6 infection. This was demonstrated by detection of viral DNA in the absence of antibody in the acute plasma specimens and HHV-6 DNA viral loads of more than 5.3 log10 genome copies/5 μl in the whole blood specimens, a profile previously shown to be diagnostic of recent primary HHV-6 infection. None of the patients had evidence of recent EBV or hepatitis B infection. We conclude that primary HHV-6 infection may be associated with GCS in some infants.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PDEen_HK
dc.relation.ispartofPediatric Dermatologyen_HK
dc.titleA prospective case control study of the association of Gianotti-Crosti syndrome with human herpesvirus 6 and human herpesvirus 7 infectionsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0736-8046&volume=19 &issue=6&spage=492&epage=497&date=2002&atitle=A+prospective+case+control+study+of+the+association+of+Gianotti-Crosti+syndrome+with+human+herpesvirus+6+and+human+herpesvirus+7+infectionsen_HK
dc.identifier.emailChiu, SSS: ssschiu@hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.authorityChiu, SSS=rp00421en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1525-1470.2002.00217.xen_HK
dc.identifier.pmid12437548-
dc.identifier.scopuseid_2-s2.0-18744395739en_HK
dc.identifier.hkuros75847en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-18744395739&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue6en_HK
dc.identifier.spage492en_HK
dc.identifier.epage497en_HK
dc.identifier.isiWOS:000179412700004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChuh, AAT=7004650631en_HK
dc.identifier.scopusauthoridChan, HHL=24555248900en_HK
dc.identifier.scopusauthoridChiu, SSS=7202291500en_HK
dc.identifier.scopusauthoridNg, HY=7401619263en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK

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