Article: The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese

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TitleThe association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese
AuthorsNg, MW1
Zhou, G4
Chong, WP1
Lee, LWY1
Law, HKW1
Zhang, H4
Wong, WHS1
Fok, SFS1
Zhai, Y4
Yung, RWH3
Chow, EY5
Au, KL2
Chan, EYT1
Lim, W6
Peiris, JSM1
He, F4
Lau, YL1
Issue Date2007
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/
CitationBmc Infectious Diseases, 2007, v. 7 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1471-2334-7-50
AbstractBackground: Chemokines play important roles in inflammation and antiviral action. We examined whether polymorphisms of RANTES, IP-10 and Mig affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: We tested the polymorphisms of RANTES, IP-10 and Mig for their associations with SARS in 495 Hong Kong Chinese SARS patients and 578 controls. Then we tried to confirm the results in 356 Beijing Chinese SARS patients and 367 controls. Results: RANTES -28 G allele was associated with SARS susceptibility in Hong Kong Chinese (P < 0.0001, OR = 2.80, 95%CI:2.11-3.71). Individuals with RANTES -28 CG and GG genotypes had a 3.28-fold (95%CI:2.32-4.64) and 3.06-fold (95%CI:1.47-6.39) increased risk of developing SARS respectively (P < 0.0001). This -28 G allele conferred risk of death in a gene-dosage dependent manner (P = 0.014) with CG and GG individuals having a 2.12-fold (95% CI: 1.11-4.06) and 4.01-fold (95% CI: 1.30-12.4) increased risk. For the replication of RANTES data in Beijing Chinese, the -28 G allele was not associated with susceptibility to SARS. However, -28 CG (OR = 4.27, 95%CI:1.64-11.1) and GG (OR = 3.34, 95%CI:0.37-30.7) were associated with admission to intensive care units or death due to SARS (P = 0.011). Conclusion: RANTES -28 G allele plays a role in the pathogenesis of SARS. © 2007 Ng et al; licensee BioMed Central Ltd.
ISSN1471-2334
2011 Impact Factor: 3.118
2011 SCImago Journal Rankings: 0.263
DOIhttp://dx.doi.org/10.1186/1471-2334-7-50
ISI Accession Number IDWOS:000247617800001
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorNg, MW
dc.contributor.authorZhou, G
dc.contributor.authorChong, WP
dc.contributor.authorLee, LWY
dc.contributor.authorLaw, HKW
dc.contributor.authorZhang, H
dc.contributor.authorWong, WHS
dc.contributor.authorFok, SFS
dc.contributor.authorZhai, Y
dc.contributor.authorYung, RWH
dc.contributor.authorChow, EY
dc.contributor.authorAu, KL
dc.contributor.authorChan, EYT
dc.contributor.authorLim, W
dc.contributor.authorPeiris, JSM
dc.contributor.authorHe, F
dc.contributor.authorLau, YL
dc.date.accessioned2010-09-06T07:48:21Z
dc.date.available2010-09-06T07:48:21Z
dc.date.issued2007
dc.description.abstractBackground: Chemokines play important roles in inflammation and antiviral action. We examined whether polymorphisms of RANTES, IP-10 and Mig affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: We tested the polymorphisms of RANTES, IP-10 and Mig for their associations with SARS in 495 Hong Kong Chinese SARS patients and 578 controls. Then we tried to confirm the results in 356 Beijing Chinese SARS patients and 367 controls. Results: RANTES -28 G allele was associated with SARS susceptibility in Hong Kong Chinese (P < 0.0001, OR = 2.80, 95%CI:2.11-3.71). Individuals with RANTES -28 CG and GG genotypes had a 3.28-fold (95%CI:2.32-4.64) and 3.06-fold (95%CI:1.47-6.39) increased risk of developing SARS respectively (P < 0.0001). This -28 G allele conferred risk of death in a gene-dosage dependent manner (P = 0.014) with CG and GG individuals having a 2.12-fold (95% CI: 1.11-4.06) and 4.01-fold (95% CI: 1.30-12.4) increased risk. For the replication of RANTES data in Beijing Chinese, the -28 G allele was not associated with susceptibility to SARS. However, -28 CG (OR = 4.27, 95%CI:1.64-11.1) and GG (OR = 3.34, 95%CI:0.37-30.7) were associated with admission to intensive care units or death due to SARS (P = 0.011). Conclusion: RANTES -28 G allele plays a role in the pathogenesis of SARS. © 2007 Ng et al; licensee BioMed Central Ltd.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationBmc Infectious Diseases, 2007, v. 7 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1471-2334-7-50
dc.identifier.citeulike1355486
dc.identifier.doihttp://dx.doi.org/10.1186/1471-2334-7-50
dc.identifier.hkuros128416
dc.identifier.isiWOS:000247617800001
dc.identifier.issn1471-2334
2011 Impact Factor: 3.118
2011 SCImago Journal Rankings: 0.263
dc.identifier.openurl
dc.identifier.scopuseid_2-s2.0-34347374296
dc.identifier.urihttp://hdl.handle.net/10722/78916
dc.identifier.volume7
dc.languageeng
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/
dc.publisher.placeUnited Kingdom
dc.relation.ispartofBMC Infectious Diseases
dc.relation.referencesReferences in Scopus
dc.rightsB M C Infectious Diseases. Copyright © BioMed Central Ltd.
dc.titleThe association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Princess Margaret Hospital Hong Kong
  3. Pamela Youde Nethersole Eastern Hospital
  4. Beijing Institute of Radiation Medicine
  5. United Christian Hospital Hong Kong
  6. Government Virus Unit