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Article: The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese

TitleThe association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese
Authors
Issue Date2007
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/
Citation
Bmc Infectious Diseases, 2007, v. 7 How to Cite?
Abstract
Background: Chemokines play important roles in inflammation and antiviral action. We examined whether polymorphisms of RANTES, IP-10 and Mig affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: We tested the polymorphisms of RANTES, IP-10 and Mig for their associations with SARS in 495 Hong Kong Chinese SARS patients and 578 controls. Then we tried to confirm the results in 356 Beijing Chinese SARS patients and 367 controls. Results: RANTES -28 G allele was associated with SARS susceptibility in Hong Kong Chinese (P < 0.0001, OR = 2.80, 95%CI:2.11-3.71). Individuals with RANTES -28 CG and GG genotypes had a 3.28-fold (95%CI:2.32-4.64) and 3.06-fold (95%CI:1.47-6.39) increased risk of developing SARS respectively (P < 0.0001). This -28 G allele conferred risk of death in a gene-dosage dependent manner (P = 0.014) with CG and GG individuals having a 2.12-fold (95% CI: 1.11-4.06) and 4.01-fold (95% CI: 1.30-12.4) increased risk. For the replication of RANTES data in Beijing Chinese, the -28 G allele was not associated with susceptibility to SARS. However, -28 CG (OR = 4.27, 95%CI:1.64-11.1) and GG (OR = 3.34, 95%CI:0.37-30.7) were associated with admission to intensive care units or death due to SARS (P = 0.011). Conclusion: RANTES -28 G allele plays a role in the pathogenesis of SARS. © 2007 Ng et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/78916
ISSN
2013 Impact Factor: 2.561
2013 SCImago Journal Rankings: 1.420
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
  2. Princess Margaret Hospital Hong Kong
  3. Pamela Youde Nethersole Eastern Hospital
  4. Beijing Institute of Radiation Medicine
  5. United Christian Hospital Hong Kong
  6. Government Virus Unit
DC FieldValueLanguage
dc.contributor.authorNg, MWen_HK
dc.contributor.authorZhou, Gen_HK
dc.contributor.authorChong, WPen_HK
dc.contributor.authorLee, LWYen_HK
dc.contributor.authorLaw, HKWen_HK
dc.contributor.authorZhang, Hen_HK
dc.contributor.authorWong, WHSen_HK
dc.contributor.authorFok, SFSen_HK
dc.contributor.authorZhai, Yen_HK
dc.contributor.authorYung, RWHen_HK
dc.contributor.authorChow, EYen_HK
dc.contributor.authorAu, KLen_HK
dc.contributor.authorChan, EYTen_HK
dc.contributor.authorLim, Wen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorHe, Fen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2010-09-06T07:48:21Z-
dc.date.available2010-09-06T07:48:21Z-
dc.date.issued2007en_HK
dc.identifier.citationBmc Infectious Diseases, 2007, v. 7en_HK
dc.identifier.issn1471-2334en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78916-
dc.description.abstractBackground: Chemokines play important roles in inflammation and antiviral action. We examined whether polymorphisms of RANTES, IP-10 and Mig affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: We tested the polymorphisms of RANTES, IP-10 and Mig for their associations with SARS in 495 Hong Kong Chinese SARS patients and 578 controls. Then we tried to confirm the results in 356 Beijing Chinese SARS patients and 367 controls. Results: RANTES -28 G allele was associated with SARS susceptibility in Hong Kong Chinese (P < 0.0001, OR = 2.80, 95%CI:2.11-3.71). Individuals with RANTES -28 CG and GG genotypes had a 3.28-fold (95%CI:2.32-4.64) and 3.06-fold (95%CI:1.47-6.39) increased risk of developing SARS respectively (P < 0.0001). This -28 G allele conferred risk of death in a gene-dosage dependent manner (P = 0.014) with CG and GG individuals having a 2.12-fold (95% CI: 1.11-4.06) and 4.01-fold (95% CI: 1.30-12.4) increased risk. For the replication of RANTES data in Beijing Chinese, the -28 G allele was not associated with susceptibility to SARS. However, -28 CG (OR = 4.27, 95%CI:1.64-11.1) and GG (OR = 3.34, 95%CI:0.37-30.7) were associated with admission to intensive care units or death due to SARS (P = 0.011). Conclusion: RANTES -28 G allele plays a role in the pathogenesis of SARS. © 2007 Ng et al; licensee BioMed Central Ltd.en_HK
dc.languageengen_HK
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/en_HK
dc.relation.ispartofBMC Infectious Diseasesen_HK
dc.rightsB M C Infectious Diseases. Copyright © BioMed Central Ltd.en_HK
dc.titleThe association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1471-2334&volume=7&spage=50&epage=&date=2007&atitle=The+association+of+RANTES+polymorphism+with+severe+acute+respiratory+syndrome+in+Hong+Kong+and+Beijing+Chineseen_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailLau, YL: lauylung@hku.hken_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1186/1471-2334-7-50en_HK
dc.identifier.pmid17540042-
dc.identifier.scopuseid_2-s2.0-34347374296en_HK
dc.identifier.hkuros128416en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34347374296&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.isiWOS:000247617800001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridNg, MW=9238285000en_HK
dc.identifier.scopusauthoridZhou, G=7403686465en_HK
dc.identifier.scopusauthoridChong, WP=8634104400en_HK
dc.identifier.scopusauthoridLee, LWY=36984969300en_HK
dc.identifier.scopusauthoridLaw, HKW=7101939394en_HK
dc.identifier.scopusauthoridZhang, H=36077804300en_HK
dc.identifier.scopusauthoridWong, WHS=13310222200en_HK
dc.identifier.scopusauthoridFok, SFS=7005182792en_HK
dc.identifier.scopusauthoridZhai, Y=55430127000en_HK
dc.identifier.scopusauthoridYung, RWH=7005594277en_HK
dc.identifier.scopusauthoridChow, EY=7102595571en_HK
dc.identifier.scopusauthoridAu, KL=7006641953en_HK
dc.identifier.scopusauthoridChan, EYT=7401994013en_HK
dc.identifier.scopusauthoridLim, W=16205075400en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridHe, F=7201951930en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.citeulike1355486-

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