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Article: Sequence variation of the amino-terminal antigenic domains of glycoprotein B of human cytomegalovirus strains isolated from Chinese patients

TitleSequence variation of the amino-terminal antigenic domains of glycoprotein B of human cytomegalovirus strains isolated from Chinese patients
Authors
Issue Date1994
PublisherSpringer Wien. The Journal's web site is located at http://www.springer.com/springerwiennewyork/medicine/journal/705
Citation
Archives Of Virology, 1994, v. 137 n. 1-2, p. 133-138 How to Cite?
AbstractTo study the genetic variation of human cytomegalovirus (HCMV) in Asian populations, the amino-terminal antigenic domains of glycoprotein B of HCMVs isolated from ethnic Chinese transplant patients were cloned and sequenced. The nucleotide and encoded amino acid sequences were compared with published sequences of AD169 and Towne laboratory strains. Within the region sequenced, 9 out of 15 clinical isolates (60%) possessed a peptide configuration similar to that of strain AD169 while 6 isolates (40%) displayed a peptide configuration similar to that of strain Towne. The nucleotide and amino acid identities of AD169-like clinical isolates exhibited variations of 95.4%-99.6% and 95.4%-100% respectively, whereas the identities of Towne-like clinical isolates were within the range of 97.3%-100% and 96.6%-100% at the nucleotide and amino acid levels. The previously defined neutralizing epitope was conserved among the clinical isolates sequenced while unique non-conservative amino acid substitutions were detected in the non-neutralizing epitope within the amino-terminal antigenic domain of glycoprotein B of all AD169-like isolates (Y- > S) and one of the Towne-like isolates (R- > Q).
Persistent Identifierhttp://hdl.handle.net/10722/78912
ISSN
2015 Impact Factor: 2.255
2015 SCImago Journal Rankings: 1.086
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorShiu, SYWen_HK
dc.contributor.authorChan, KMen_HK
dc.contributor.authorLo, SKFen_HK
dc.contributor.authorIp, KWYen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorHeath, RBen_HK
dc.date.accessioned2010-09-06T07:48:18Z-
dc.date.available2010-09-06T07:48:18Z-
dc.date.issued1994en_HK
dc.identifier.citationArchives Of Virology, 1994, v. 137 n. 1-2, p. 133-138en_HK
dc.identifier.issn0304-8608en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78912-
dc.description.abstractTo study the genetic variation of human cytomegalovirus (HCMV) in Asian populations, the amino-terminal antigenic domains of glycoprotein B of HCMVs isolated from ethnic Chinese transplant patients were cloned and sequenced. The nucleotide and encoded amino acid sequences were compared with published sequences of AD169 and Towne laboratory strains. Within the region sequenced, 9 out of 15 clinical isolates (60%) possessed a peptide configuration similar to that of strain AD169 while 6 isolates (40%) displayed a peptide configuration similar to that of strain Towne. The nucleotide and amino acid identities of AD169-like clinical isolates exhibited variations of 95.4%-99.6% and 95.4%-100% respectively, whereas the identities of Towne-like clinical isolates were within the range of 97.3%-100% and 96.6%-100% at the nucleotide and amino acid levels. The previously defined neutralizing epitope was conserved among the clinical isolates sequenced while unique non-conservative amino acid substitutions were detected in the non-neutralizing epitope within the amino-terminal antigenic domain of glycoprotein B of all AD169-like isolates (Y- > S) and one of the Towne-like isolates (R- > Q).-
dc.languageengen_HK
dc.publisherSpringer Wien. The Journal's web site is located at http://www.springer.com/springerwiennewyork/medicine/journal/705en_HK
dc.relation.ispartofArchives of Virologyen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.subject.meshAntigens, Viral - biosynthesis-
dc.subject.meshCytomegalovirus - classification - genetics - isolation and purification-
dc.subject.meshCytomegalovirus Infections - virology-
dc.subject.meshGenetic Variation-
dc.subject.meshViral Envelope Proteins - biosynthesis - genetics-
dc.titleSequence variation of the amino-terminal antigenic domains of glycoprotein B of human cytomegalovirus strains isolated from Chinese patientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-8608&volume=137&issue=1-2&spage=133&epage=138&date=1994&atitle=Sequence+variation+of+the+amino-terminal+antigenic+domains+of+glycoprotein+B+of+human+cytomegalovirus+strains+isolated+from+Chinese+patientsen_HK
dc.identifier.emailShiu, SYW: sywshiu@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityShiu, SYW=rp00384en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid7979986-
dc.identifier.scopuseid_2-s2.0-0027974589en_HK
dc.identifier.hkuros4344en_HK
dc.identifier.volume137en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage133en_HK
dc.identifier.epage138en_HK
dc.identifier.isiWOS:A1994NY47400011-
dc.publisher.placeAustriaen_HK
dc.identifier.scopusauthoridShiu, SYW=7005550655en_HK
dc.identifier.scopusauthoridChan, KM=7406034671en_HK
dc.identifier.scopusauthoridLo, SKF=7401542391en_HK
dc.identifier.scopusauthoridIp, KWY=7006315589en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridHeath, RB=7202694890en_HK

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