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Article: Prevalence and genetic diversity of coronaviruses in bats from China

TitlePrevalence and genetic diversity of coronaviruses in bats from China
Authors
Issue Date2006
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2006, v. 80 n. 15, p. 7481-7490 How to Cite?
AbstractCoronaviruses can infect a variety of animals including poultry, livestock, and humans and are currently classified into three groups. The interspecies transmissions of coronaviruses between different hosts form a complex ecosystem of which little is known. The outbreak of severe acute respiratory syndrome (SARS) and the recent identification of new coronaviruses have highlighted the necessity for further investigation of coronavirus ecology, in particular the role of bats and other wild animals. In this study, we sampled bat populations in 15 provinces of China and reveal that approximately 6.5% of the bats, from diverse species distributed throughout the region, harbor coronaviruses. Full genomes of four coronavirues from bats were sequenced and analyzed. Phylogenetic analyses of the spike, envelope, membrane, and nucleoprotein structural proteins and the two conserved replicase domains, putative RNA-dependent RNA polymerase and RNA helicase, revealed that bat coronaviruses cluster in three different groups: group 1, another group that includes all SARS and SARS-like coronaviruses (putative group 4), and an independent bat coronavirus group (putative group 5). Further genetic analyses snowed that different species of bats maintain coronaviruses from different groups and that a single bat species from different geographic locations supports similar coronaviruses. Thus, the findings of this study suggest that bats may play an integral role in the ecology and evolution of coronaviruses. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/78895
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, XCen_HK
dc.contributor.authorZhang, JXen_HK
dc.contributor.authorZhang, SYen_HK
dc.contributor.authorWang, Pen_HK
dc.contributor.authorFan, XHen_HK
dc.contributor.authorLi, LFen_HK
dc.contributor.authorLi, Gen_HK
dc.contributor.authorDong, BQen_HK
dc.contributor.authorLiu, Wen_HK
dc.contributor.authorCheung, CLen_HK
dc.contributor.authorXu, KMen_HK
dc.contributor.authorSong, WJen_HK
dc.contributor.authorVijaykrishna, Den_HK
dc.contributor.authorPoon, LLMen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorSmith, GJDen_HK
dc.contributor.authorChen, Hen_HK
dc.contributor.authorGuan, Yen_HK
dc.date.accessioned2010-09-06T07:48:07Z-
dc.date.available2010-09-06T07:48:07Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of Virology, 2006, v. 80 n. 15, p. 7481-7490en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/78895-
dc.description.abstractCoronaviruses can infect a variety of animals including poultry, livestock, and humans and are currently classified into three groups. The interspecies transmissions of coronaviruses between different hosts form a complex ecosystem of which little is known. The outbreak of severe acute respiratory syndrome (SARS) and the recent identification of new coronaviruses have highlighted the necessity for further investigation of coronavirus ecology, in particular the role of bats and other wild animals. In this study, we sampled bat populations in 15 provinces of China and reveal that approximately 6.5% of the bats, from diverse species distributed throughout the region, harbor coronaviruses. Full genomes of four coronavirues from bats were sequenced and analyzed. Phylogenetic analyses of the spike, envelope, membrane, and nucleoprotein structural proteins and the two conserved replicase domains, putative RNA-dependent RNA polymerase and RNA helicase, revealed that bat coronaviruses cluster in three different groups: group 1, another group that includes all SARS and SARS-like coronaviruses (putative group 4), and an independent bat coronavirus group (putative group 5). Further genetic analyses snowed that different species of bats maintain coronaviruses from different groups and that a single bat species from different geographic locations supports similar coronaviruses. Thus, the findings of this study suggest that bats may play an integral role in the ecology and evolution of coronaviruses. Copyright © 2006, American Society for Microbiology. All Rights Reserved.en_HK
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshChinaen_HK
dc.subject.meshChiroptera - virologyen_HK
dc.subject.meshCoronavirus - classification - genetics - isolation & purificationen_HK
dc.subject.meshEvolution, Molecularen_HK
dc.subject.meshGenetic Variationen_HK
dc.subject.meshGenome, Viralen_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.subject.meshPhylogenyen_HK
dc.subject.meshPrevalenceen_HK
dc.subject.meshRNA, Viral - geneticsen_HK
dc.subject.meshSequence Analysis, DNAen_HK
dc.subject.meshViral Proteins - geneticsen_HK
dc.titlePrevalence and genetic diversity of coronaviruses in bats from Chinaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-538X&volume=80&issue=15&spage=7481&epage=7490&date=2006&atitle=Prevalence+and+genetic+diversity+of+coronaviruses+in+bats+from+Chinaen_HK
dc.identifier.emailZhang, JX: zhangajx@hkucc.hku.hken_HK
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailSmith, GJD: gjsmith@hkucc1.hku.hken_HK
dc.identifier.emailChen, H: hlchen@hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.authorityZhang, JX=rp00413en_HK
dc.identifier.authorityPoon, LLM=rp00484en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authoritySmith, GJD=rp00444en_HK
dc.identifier.authorityChen, H=rp00383en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1128/JVI.00697-06en_HK
dc.identifier.pmid16840328-
dc.identifier.scopuseid_2-s2.0-33746214702en_HK
dc.identifier.hkuros120651en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746214702&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume80en_HK
dc.identifier.issue15en_HK
dc.identifier.spage7481en_HK
dc.identifier.epage7490en_HK
dc.identifier.isiWOS:000239189100020-
dc.publisher.placeUnited Statesen_HK
dc.identifier.f10001033498-
dc.identifier.scopusauthoridTang, XC=22942258000en_HK
dc.identifier.scopusauthoridZhang, JX=12752135600en_HK
dc.identifier.scopusauthoridZhang, SY=35212214400en_HK
dc.identifier.scopusauthoridWang, P=13907209900en_HK
dc.identifier.scopusauthoridFan, XH=35227217200en_HK
dc.identifier.scopusauthoridLi, LF=14045423100en_HK
dc.identifier.scopusauthoridLi, G=35227531800en_HK
dc.identifier.scopusauthoridDong, BQ=9333345200en_HK
dc.identifier.scopusauthoridLiu, W=36080064300en_HK
dc.identifier.scopusauthoridCheung, CL=34975244700en_HK
dc.identifier.scopusauthoridXu, KM=35228266300en_HK
dc.identifier.scopusauthoridSong, WJ=23490429800en_HK
dc.identifier.scopusauthoridVijaykrishna, D=12752817700en_HK
dc.identifier.scopusauthoridPoon, LLM=7005441747en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridSmith, GJD=8344015800en_HK
dc.identifier.scopusauthoridChen, H=26643315400en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK

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