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Article: Serum neopterin for early assessment of severity of severe acute respiratory syndrome

TitleSerum neopterin for early assessment of severity of severe acute respiratory syndrome
Authors
Issue Date2005
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yclim
Citation
Clinical Immunology, 2005, v. 116 n. 1, p. 18-26 How to Cite?
AbstractNeopterin and C-reactive protein (CRP) concentrations were determined in serum samples from 129 severe acute respiratory syndrome (SARS) patients and 156 healthy blood donors. In the patients with confirmed SARS, an early neopterin elevation was detected already at the day of onset of symptoms and rose to a maximum level of 45.0 nmol/L 3 days after the onset. All SARS patients had elevated neopterin concentrations (>10 nmol/L) within 9 days after the onset. The mean neopterin concentrations were 34.2 nmol/L in acute sera of SARS patients, 5.1 nmol/L in convalescent sera, and 6.7 nmol/L in healthy controls. In contrast, the mean CRP concentrations in both acute and convalescent sera of SARS patients were in the normal range (<10 mg/L). Serum neopterin level in SARS patients was associated with fever period and thus the clinical progression of the disease, while there was no significant correlation between the CRP level and the fever period. Serum neopterin may allow early assessment of the severity of SARS. The decrease of neopterin level was found after steroid treatment, which indicates that blood samples should be collected before steroid treatment for the neopterin measurement. © 2005 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/78881
ISSN
2015 Impact Factor: 4.034
2015 SCImago Journal Rankings: 1.848
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZheng, Ben_HK
dc.contributor.authorCao, KYen_HK
dc.contributor.authorChan, CPYen_HK
dc.contributor.authorChoi, JWYen_HK
dc.contributor.authorLeung, Wen_HK
dc.contributor.authorLeung, Men_HK
dc.contributor.authorDuan, ZHen_HK
dc.contributor.authorGao, Yen_HK
dc.contributor.authorWang, Men_HK
dc.contributor.authorDi, Ben_HK
dc.contributor.authorHollidt, JMen_HK
dc.contributor.authorBergmann, Aen_HK
dc.contributor.authorLehmann, Men_HK
dc.contributor.authorRenneberg, Ien_HK
dc.contributor.authorTam, JSLen_HK
dc.contributor.authorChan, PKSen_HK
dc.contributor.authorCautherley, GWHen_HK
dc.contributor.authorFuchs, Den_HK
dc.contributor.authorRenneberg, Ren_HK
dc.date.accessioned2010-09-06T07:47:57Z-
dc.date.available2010-09-06T07:47:57Z-
dc.date.issued2005en_HK
dc.identifier.citationClinical Immunology, 2005, v. 116 n. 1, p. 18-26en_HK
dc.identifier.issn1521-6616en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78881-
dc.description.abstractNeopterin and C-reactive protein (CRP) concentrations were determined in serum samples from 129 severe acute respiratory syndrome (SARS) patients and 156 healthy blood donors. In the patients with confirmed SARS, an early neopterin elevation was detected already at the day of onset of symptoms and rose to a maximum level of 45.0 nmol/L 3 days after the onset. All SARS patients had elevated neopterin concentrations (>10 nmol/L) within 9 days after the onset. The mean neopterin concentrations were 34.2 nmol/L in acute sera of SARS patients, 5.1 nmol/L in convalescent sera, and 6.7 nmol/L in healthy controls. In contrast, the mean CRP concentrations in both acute and convalescent sera of SARS patients were in the normal range (<10 mg/L). Serum neopterin level in SARS patients was associated with fever period and thus the clinical progression of the disease, while there was no significant correlation between the CRP level and the fever period. Serum neopterin may allow early assessment of the severity of SARS. The decrease of neopterin level was found after steroid treatment, which indicates that blood samples should be collected before steroid treatment for the neopterin measurement. © 2005 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yclimen_HK
dc.relation.ispartofClinical Immunologyen_HK
dc.subject.meshAdrenal Cortex Hormones - pharmacologyen_HK
dc.subject.meshAntibodies - blooden_HK
dc.subject.meshBiological Markersen_HK
dc.subject.meshHumansen_HK
dc.subject.meshKineticsen_HK
dc.subject.meshNeopterin - blooden_HK
dc.subject.meshSevere Acute Respiratory Syndrome - blood - diagnosis - drug therapy - immunologyen_HK
dc.subject.meshSeverity of Illness Indexen_HK
dc.subject.meshTime Factorsen_HK
dc.titleSerum neopterin for early assessment of severity of severe acute respiratory syndromeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1521-6616&volume=16&spage=18&epage=26&date=2005&atitle=Serum+Neopterin+for+Early+Assessment+of+Severity+of+Severe+Acute+Respiratory+Syndromeen_HK
dc.identifier.emailZheng, B:bzheng@hkucc.hku.hken_HK
dc.identifier.authorityZheng, B=rp00353en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.clim.2005.03.009en_HK
dc.identifier.pmid15925828-
dc.identifier.scopuseid_2-s2.0-21144435650en_HK
dc.identifier.hkuros105579en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-21144435650&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume116en_HK
dc.identifier.issue1en_HK
dc.identifier.spage18en_HK
dc.identifier.epage26en_HK
dc.identifier.isiWOS:000229824400004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZheng, B=7201780588en_HK
dc.identifier.scopusauthoridCao, KY=15845100900en_HK
dc.identifier.scopusauthoridChan, CPY=22033468200en_HK
dc.identifier.scopusauthoridChoi, JWY=8639814000en_HK
dc.identifier.scopusauthoridLeung, W=8639814100en_HK
dc.identifier.scopusauthoridLeung, M=8639814200en_HK
dc.identifier.scopusauthoridDuan, ZH=55183155000en_HK
dc.identifier.scopusauthoridGao, Y=7404706103en_HK
dc.identifier.scopusauthoridWang, M=7406685232en_HK
dc.identifier.scopusauthoridDi, B=6602190900en_HK
dc.identifier.scopusauthoridHollidt, JM=6506927269en_HK
dc.identifier.scopusauthoridBergmann, A=7006567116en_HK
dc.identifier.scopusauthoridLehmann, M=36644216200en_HK
dc.identifier.scopusauthoridRenneberg, I=6508034762en_HK
dc.identifier.scopusauthoridTam, JSL=24788939600en_HK
dc.identifier.scopusauthoridChan, PKS=7403497792en_HK
dc.identifier.scopusauthoridCautherley, GWH=8639815300en_HK
dc.identifier.scopusauthoridFuchs, D=35414205100en_HK
dc.identifier.scopusauthoridRenneberg, R=7006374338en_HK

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