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Article: Bacteremia due to Staphylococcus aureus with reduced susceptibility to vancomycin

TitleBacteremia due to Staphylococcus aureus with reduced susceptibility to vancomycin
Authors
Issue Date2000
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio
Citation
Diagnostic Microbiology And Infectious Disease, 2000, v. 36 n. 4, p. 261-268 How to Cite?
AbstractFour cases of bacteremia caused by Staphylococcus aureus with heteroresistance to vancomycin (hetero-VRSA) were described. In at least two of these four mortalities, the cause of death was temporally related to the hetero-VRSA bacteremia. The vancomycin and teicoplanin MICs of the resistant subpopulations of these four hetero-VRSA were 8 and 24 μg/ml, respectively. All isolates were producers of β-lactamase, produced penicillin-binding protein PBP2a, and possessed the mecA gene accounting for methicillin resistance. Thickening of the peptidoglycan cell wall was observed by electron microscopy. When ampicillin was combined with vancomycin, in vitro synergism was detected using the checkerboard titration method (εFIC = 0.13). The use of vancomycin plus ampicillin-sulbactam could be a viable option in treating severe hetero-VRSA infection in view of the higher affinity of ampicillin toward PBP2a. Copyright (C) 2000 Elsevier Science Inc.
Persistent Identifierhttp://hdl.handle.net/10722/78878
ISSN
2015 Impact Factor: 2.45
2015 SCImago Journal Rankings: 1.142
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, SSYen_HK
dc.contributor.authorNg, TKen_HK
dc.contributor.authorYam, WCen_HK
dc.contributor.authorTsang, DNCen_HK
dc.contributor.authorWoo, PCYen_HK
dc.contributor.authorFung, SKSen_HK
dc.contributor.authorYuen, KYen_HK
dc.date.accessioned2010-09-06T07:47:55Z-
dc.date.available2010-09-06T07:47:55Z-
dc.date.issued2000en_HK
dc.identifier.citationDiagnostic Microbiology And Infectious Disease, 2000, v. 36 n. 4, p. 261-268en_HK
dc.identifier.issn0732-8893en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78878-
dc.description.abstractFour cases of bacteremia caused by Staphylococcus aureus with heteroresistance to vancomycin (hetero-VRSA) were described. In at least two of these four mortalities, the cause of death was temporally related to the hetero-VRSA bacteremia. The vancomycin and teicoplanin MICs of the resistant subpopulations of these four hetero-VRSA were 8 and 24 μg/ml, respectively. All isolates were producers of β-lactamase, produced penicillin-binding protein PBP2a, and possessed the mecA gene accounting for methicillin resistance. Thickening of the peptidoglycan cell wall was observed by electron microscopy. When ampicillin was combined with vancomycin, in vitro synergism was detected using the checkerboard titration method (εFIC = 0.13). The use of vancomycin plus ampicillin-sulbactam could be a viable option in treating severe hetero-VRSA infection in view of the higher affinity of ampicillin toward PBP2a. Copyright (C) 2000 Elsevier Science Inc.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobioen_HK
dc.relation.ispartofDiagnostic Microbiology and Infectious Diseaseen_HK
dc.rightsDiagnostic Microbiology and Infectious Disease. Copyright © Elsevier Inc.en_HK
dc.subject.meshAgeden_HK
dc.subject.meshAmpicillin - therapeutic useen_HK
dc.subject.meshAnti-Bacterial Agents - therapeutic useen_HK
dc.subject.meshBacteremia - drug therapy - microbiologyen_HK
dc.subject.meshBacterial Proteinsen_HK
dc.subject.meshCarrier Proteins - analysisen_HK
dc.subject.meshDNA, Bacterial - analysisen_HK
dc.subject.meshElectrophoresis, Gel, Pulsed-Fielden_HK
dc.subject.meshFatal Outcomeen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHexosyltransferasesen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMethicillin Resistanceen_HK
dc.subject.meshMicrobial Sensitivity Testsen_HK
dc.subject.meshMicroscopy, Electronen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMuramoylpentapeptide Carboxypeptidase - analysisen_HK
dc.subject.meshPenicillin-Binding Proteinsen_HK
dc.subject.meshPenicillins - therapeutic useen_HK
dc.subject.meshPeptidyl Transferasesen_HK
dc.subject.meshStaphylococcus aureus - drug effects - isolation & purification - ultrastructureen_HK
dc.subject.meshTeicoplanin - therapeutic useen_HK
dc.subject.meshVancomycin - therapeutic useen_HK
dc.subject.meshVancomycin Resistanceen_HK
dc.subject.meshbeta-Lactamases - analysisen_HK
dc.titleBacteremia due to Staphylococcus aureus with reduced susceptibility to vancomycinen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0732-8893&volume=36&issue=4&spage=261&epage=268&date=2000&atitle=Bacteremia+due+to+Staphylococcus+aureus+with+reduced+susceptibility+to+vancomycinen_HK
dc.identifier.emailWong, SSY:samsonsy@hkucc.hku.hken_HK
dc.identifier.emailYam, WC:wcyam@hkucc.hku.hken_HK
dc.identifier.emailWoo, PCY:pcywoo@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityWong, SSY=rp00395en_HK
dc.identifier.authorityYam, WC=rp00313en_HK
dc.identifier.authorityWoo, PCY=rp00430en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0732-8893(99)00141-8en_HK
dc.identifier.pmid10764969-
dc.identifier.scopuseid_2-s2.0-0034074492en_HK
dc.identifier.hkuros54556en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034074492&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume36en_HK
dc.identifier.issue4en_HK
dc.identifier.spage261en_HK
dc.identifier.epage268en_HK
dc.identifier.isiWOS:000086574200008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, SSY=13310021400en_HK
dc.identifier.scopusauthoridNg, TK=7402229817en_HK
dc.identifier.scopusauthoridYam, WC=7004281720en_HK
dc.identifier.scopusauthoridTsang, DNC=7005609132en_HK
dc.identifier.scopusauthoridWoo, PCY=7201801340en_HK
dc.identifier.scopusauthoridFung, SKS=19834870100en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK

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