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Article: Immune response to influenza vaccination in community-dwelling Chinese elderly persons

TitleImmune response to influenza vaccination in community-dwelling Chinese elderly persons
Authors
KeywordsChinese
Elderly
Influenza
Vaccination
Issue Date2006
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccine
Citation
Vaccine, 2006, v. 24 n. 25, p. 5371-5380 How to Cite?
AbstractWe investigated the immune antibody response to influenza vaccine in community-dwelling Chinese elderly persons in Hong Kong. One hundred and twenty-eight subjects were recruited in a single-blind, randomized, and placebo-controlled trial. There was no significant baseline difference between the vaccine and placebo groups regarding the seroprotection rates (PR) (haemagglutination inhibition [HI] titre ≥1:40) and geometric mean titres (GMT) of the HI antibody titers. The PR, GMTs and serological response rates increased significantly in the vaccinated versus placebo groups in A-H1N1 at both weeks 4 and month 6. The GMTs and serological response rates but not the PR for A-H3N2 and influenza B increased significantly in vaccinated versus placebo group at week 4 and month 6 post-vaccination. Multivariate logistic regression analyses of the seroconversion rate for A-H3N2 within the vaccinated group showed that gender, coronary heart disease and the serum albumin level were significant predictors (p = 0.018, 0.009 and 0.025, respectively). Influenza vaccination provoked a protective HI antibody response in community-living Chinese elderly persons. The mean number of unplanned hospital admissions per subject over 6 months was significantly lower in the vaccinated than in the placebo groups. Hospitalized elderly persons had poorer nutrition, 4-week post-immunization HI antibody titres and lower mini-mental state examination (MMSE) score than non-hospitalized elderly persons. Logistic regression analyses showed that chronic obstructive airway disease significantly increased the risk of hospitalization while the serum albumin level and 4-week A-H3N2 PR (HI ≥ 40) were independent predictors of a decreased risk of hospitalizations. © 2006 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/78859
ISSN
2014 Impact Factor: 3.624
2014 SCImago Journal Rankings: 1.740
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHui, SLen_HK
dc.contributor.authorChu, LWen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorChu, Den_HK
dc.contributor.authorTsui, Wen_HK
dc.date.accessioned2010-09-06T07:47:41Z-
dc.date.available2010-09-06T07:47:41Z-
dc.date.issued2006en_HK
dc.identifier.citationVaccine, 2006, v. 24 n. 25, p. 5371-5380en_HK
dc.identifier.issn0264-410Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/78859-
dc.description.abstractWe investigated the immune antibody response to influenza vaccine in community-dwelling Chinese elderly persons in Hong Kong. One hundred and twenty-eight subjects were recruited in a single-blind, randomized, and placebo-controlled trial. There was no significant baseline difference between the vaccine and placebo groups regarding the seroprotection rates (PR) (haemagglutination inhibition [HI] titre ≥1:40) and geometric mean titres (GMT) of the HI antibody titers. The PR, GMTs and serological response rates increased significantly in the vaccinated versus placebo groups in A-H1N1 at both weeks 4 and month 6. The GMTs and serological response rates but not the PR for A-H3N2 and influenza B increased significantly in vaccinated versus placebo group at week 4 and month 6 post-vaccination. Multivariate logistic regression analyses of the seroconversion rate for A-H3N2 within the vaccinated group showed that gender, coronary heart disease and the serum albumin level were significant predictors (p = 0.018, 0.009 and 0.025, respectively). Influenza vaccination provoked a protective HI antibody response in community-living Chinese elderly persons. The mean number of unplanned hospital admissions per subject over 6 months was significantly lower in the vaccinated than in the placebo groups. Hospitalized elderly persons had poorer nutrition, 4-week post-immunization HI antibody titres and lower mini-mental state examination (MMSE) score than non-hospitalized elderly persons. Logistic regression analyses showed that chronic obstructive airway disease significantly increased the risk of hospitalization while the serum albumin level and 4-week A-H3N2 PR (HI ≥ 40) were independent predictors of a decreased risk of hospitalizations. © 2006 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccineen_HK
dc.relation.ispartofVaccineen_HK
dc.rightsVaccine. Copyright © Elsevier Ltd.en_HK
dc.subjectChineseen_HK
dc.subjectElderlyen_HK
dc.subjectInfluenzaen_HK
dc.subjectVaccinationen_HK
dc.titleImmune response to influenza vaccination in community-dwelling Chinese elderly personsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0264-410X&volume=24&issue=25&spage=5371&epage=80&date=2006&atitle=Immune+response+to+influenza+vaccination+in+community-dwelling+Chinese+elderly+persons.en_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.vaccine.2006.04.032en_HK
dc.identifier.pmid16713661en_HK
dc.identifier.scopuseid_2-s2.0-33744513283en_HK
dc.identifier.hkuros119134en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33744513283&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue25en_HK
dc.identifier.spage5371en_HK
dc.identifier.epage5380en_HK
dc.identifier.isiWOS:000238638400013-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHui, SL=7202831766en_HK
dc.identifier.scopusauthoridChu, LW=7202236665en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridChan, KH=35338760600en_HK
dc.identifier.scopusauthoridChu, D=35108889000en_HK
dc.identifier.scopusauthoridTsui, W=18038961800en_HK

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