Article: Immune response to influenza vaccination in community-dwelling Chinese elderly persons

File Download Links for fulltext
(May Require Subscription)
Supplementary

  • Basic View
  • Metadata View
  • XML View
TitleImmune response to influenza vaccination in community-dwelling Chinese elderly persons
AuthorsHui, SL2
Chu, LW2
Peiris, JSM2
Chan, KH2
Chu, D1
Tsui, W1
KeywordsChinese
Elderly
Influenza
Vaccination
Issue Date2006
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccine
CitationVaccine, 2006, v. 24 n. 25, p. 5371-5380 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.vaccine.2006.04.032
AbstractWe investigated the immune antibody response to influenza vaccine in community-dwelling Chinese elderly persons in Hong Kong. One hundred and twenty-eight subjects were recruited in a single-blind, randomized, and placebo-controlled trial. There was no significant baseline difference between the vaccine and placebo groups regarding the seroprotection rates (PR) (haemagglutination inhibition [HI] titre ≥1:40) and geometric mean titres (GMT) of the HI antibody titers. The PR, GMTs and serological response rates increased significantly in the vaccinated versus placebo groups in A-H1N1 at both weeks 4 and month 6. The GMTs and serological response rates but not the PR for A-H3N2 and influenza B increased significantly in vaccinated versus placebo group at week 4 and month 6 post-vaccination. Multivariate logistic regression analyses of the seroconversion rate for A-H3N2 within the vaccinated group showed that gender, coronary heart disease and the serum albumin level were significant predictors (p = 0.018, 0.009 and 0.025, respectively). Influenza vaccination provoked a protective HI antibody response in community-living Chinese elderly persons. The mean number of unplanned hospital admissions per subject over 6 months was significantly lower in the vaccinated than in the placebo groups. Hospitalized elderly persons had poorer nutrition, 4-week post-immunization HI antibody titres and lower mini-mental state examination (MMSE) score than non-hospitalized elderly persons. Logistic regression analyses showed that chronic obstructive airway disease significantly increased the risk of hospitalization while the serum albumin level and 4-week A-H3N2 PR (HI ≥ 40) were independent predictors of a decreased risk of hospitalizations. © 2006 Elsevier Ltd. All rights reserved.
ISSN0264-410X
2011 Impact Factor: 3.766
2011 SCImago Journal Rankings: 0.369
DOIhttp://dx.doi.org/10.1016/j.vaccine.2006.04.032
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorHui, SL
dc.contributor.authorChu, LW
dc.contributor.authorPeiris, JSM
dc.contributor.authorChan, KH
dc.contributor.authorChu, D
dc.contributor.authorTsui, W
dc.date.accessioned2010-09-06T07:47:41Z
dc.date.available2010-09-06T07:47:41Z
dc.date.issued2006
dc.description.abstractWe investigated the immune antibody response to influenza vaccine in community-dwelling Chinese elderly persons in Hong Kong. One hundred and twenty-eight subjects were recruited in a single-blind, randomized, and placebo-controlled trial. There was no significant baseline difference between the vaccine and placebo groups regarding the seroprotection rates (PR) (haemagglutination inhibition [HI] titre ≥1:40) and geometric mean titres (GMT) of the HI antibody titers. The PR, GMTs and serological response rates increased significantly in the vaccinated versus placebo groups in A-H1N1 at both weeks 4 and month 6. The GMTs and serological response rates but not the PR for A-H3N2 and influenza B increased significantly in vaccinated versus placebo group at week 4 and month 6 post-vaccination. Multivariate logistic regression analyses of the seroconversion rate for A-H3N2 within the vaccinated group showed that gender, coronary heart disease and the serum albumin level were significant predictors (p = 0.018, 0.009 and 0.025, respectively). Influenza vaccination provoked a protective HI antibody response in community-living Chinese elderly persons. The mean number of unplanned hospital admissions per subject over 6 months was significantly lower in the vaccinated than in the placebo groups. Hospitalized elderly persons had poorer nutrition, 4-week post-immunization HI antibody titres and lower mini-mental state examination (MMSE) score than non-hospitalized elderly persons. Logistic regression analyses showed that chronic obstructive airway disease significantly increased the risk of hospitalization while the serum albumin level and 4-week A-H3N2 PR (HI ≥ 40) were independent predictors of a decreased risk of hospitalizations. © 2006 Elsevier Ltd. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationVaccine, 2006, v. 24 n. 25, p. 5371-5380 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.vaccine.2006.04.032
dc.identifier.doihttp://dx.doi.org/10.1016/j.vaccine.2006.04.032
dc.identifier.epage5380
dc.identifier.hkuros119134
dc.identifier.isiWOS:000238638400013
dc.identifier.issn0264-410X
2011 Impact Factor: 3.766
2011 SCImago Journal Rankings: 0.369
dc.identifier.issue25
dc.identifier.openurl
dc.identifier.pmid16713661
dc.identifier.scopuseid_2-s2.0-33744513283
dc.identifier.spage5371
dc.identifier.urihttp://hdl.handle.net/10722/78859
dc.identifier.volume24
dc.languageeng
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccine
dc.publisher.placeUnited Kingdom
dc.relation.ispartofVaccine
dc.relation.referencesReferences in Scopus
dc.rightsVaccine. Copyright © Elsevier Ltd.
dc.subjectChinese
dc.subjectElderly
dc.subjectInfluenza
dc.subjectVaccination
dc.titleImmune response to influenza vaccination in community-dwelling Chinese elderly persons
dc.typeArticle
Author Affiliations
  1. Sai Ying Pun General Out-Patient Clinic
  2. The University of Hong Kong