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Article: Re-emergence of fatal human influenza A subtype H5N1 disease

TitleRe-emergence of fatal human influenza A subtype H5N1 disease
Authors
Issue Date2004
PublisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet
Citation
Lancet, 2004, v. 363 n. 9409, p. 617-619 How to Cite?
AbstractHuman disease associated with influenza A subtype H5N1 re-emerged in January, 2003, for the first time since an outbreak in Hong Kong in 1997. Patients with H5N1 disease had unusually high serum concentrations of chemokines (eg, interferon induced protein-10 [IP-10] and monokine induced by interferon γ [MIG]). Taken together with a previous report that H5N1 influenza viruses induce large amounts of proinflammatory cytokines from macrophage cultures in vitro, our findings suggest that cytokine dysfunction contributes to the pathogenesis of H5N1 disease. Development of vaccines against influenza A (H5N1) virus should be made a priority.
Persistent Identifierhttp://hdl.handle.net/10722/78845
ISSN
2015 Impact Factor: 44.002
2015 SCImago Journal Rankings: 14.638
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorYu, WCen_HK
dc.contributor.authorLeung, CWen_HK
dc.contributor.authorCheung, CYen_HK
dc.contributor.authorNg, WFen_HK
dc.contributor.authorNicholls, JMen_HK
dc.contributor.authorNg, TKen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorLai, STen_HK
dc.contributor.authorLim, WLen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorGuan, Yen_HK
dc.date.accessioned2010-09-06T07:47:31Z-
dc.date.available2010-09-06T07:47:31Z-
dc.date.issued2004en_HK
dc.identifier.citationLancet, 2004, v. 363 n. 9409, p. 617-619en_HK
dc.identifier.issn0140-6736en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78845-
dc.description.abstractHuman disease associated with influenza A subtype H5N1 re-emerged in January, 2003, for the first time since an outbreak in Hong Kong in 1997. Patients with H5N1 disease had unusually high serum concentrations of chemokines (eg, interferon induced protein-10 [IP-10] and monokine induced by interferon γ [MIG]). Taken together with a previous report that H5N1 influenza viruses induce large amounts of proinflammatory cytokines from macrophage cultures in vitro, our findings suggest that cytokine dysfunction contributes to the pathogenesis of H5N1 disease. Development of vaccines against influenza A (H5N1) virus should be made a priority.en_HK
dc.languageengen_HK
dc.publisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lanceten_HK
dc.relation.ispartofLanceten_HK
dc.subject.meshAnimals-
dc.subject.meshChina - epidemiology-
dc.subject.meshInfluenza in Birds - epidemiology - transmission - virology-
dc.subject.meshInfluenza, Human - epidemiology - transmission - virology-
dc.subject.meshZoonoses - epidemiology-
dc.titleRe-emergence of fatal human influenza A subtype H5N1 diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0140-6736&volume=363&issue=9409&spage=617&epage=619 &date=2004&atitle=Re-emergence+of+fatal+human+influenza+A+subtype+H5N1+diseaseen_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailCheung, CY: chungey@hkucc.hku.hken_HK
dc.identifier.emailNicholls, JM: jmnichol@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityCheung, CY=rp00404en_HK
dc.identifier.authorityNicholls, JM=rp00364en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0140-6736(04)15595-5en_HK
dc.identifier.pmid14987888-
dc.identifier.scopuseid_2-s2.0-10744231351en_HK
dc.identifier.hkuros87065en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-10744231351&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume363en_HK
dc.identifier.issue9409en_HK
dc.identifier.spage617en_HK
dc.identifier.epage619en_HK
dc.identifier.isiWOS:000189104900012-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridYu, WC=7403914214en_HK
dc.identifier.scopusauthoridLeung, CW=7402612619en_HK
dc.identifier.scopusauthoridCheung, CY=7202061836en_HK
dc.identifier.scopusauthoridNg, WF=7401613384en_HK
dc.identifier.scopusauthoridNicholls, JM=7201463077en_HK
dc.identifier.scopusauthoridNg, TK=7402229817en_HK
dc.identifier.scopusauthoridChan, KH=7406034307en_HK
dc.identifier.scopusauthoridLai, ST=7402937038en_HK
dc.identifier.scopusauthoridLim, WL=7202378277en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK

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