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Article: Analytical sensitivity of rapid influenza antigen detection tests for swine-origin influenza virus (H1N1)

TitleAnalytical sensitivity of rapid influenza antigen detection tests for swine-origin influenza virus (H1N1)
Authors
KeywordsAntigen detection
Diagnostics
H1N1
Influenza
Pandemic
Point-of care
Issue Date2009
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jcv
Citation
Journal Of Clinical Virology, 2009, v. 45 n. 3, p. 205-207 How to Cite?
AbstractBackground: A novel swine origin influenza virus (S-OIV) (H1N1) is spreading worldwide and threatens to become pandemic. Objectives: Determine analytical sensitivity of selected commercially available rapid influenza antigen detection tests in detecting S-OIV H1N1. Study design: Serial dilutions of two S-OIV isolates, one seasonal influenza A (H1N1) isolate and a nasopharyngeal aspirate from a patient with S-OIV disease were tested in five commercially available influenza antigen detection tests and by virus isolation in cell culture. Viral M gene copy number was determined by quantitative PCR methods. Results: The analytical sensitivity of the five influenza antigen detection tests for S-OIV (tissue culture infectious dose 50 (TCID50) log10 3.3-4.7 was comparable with that of seasonal influenza (TCID50 log10 4.0-4.5). Conclusion: The analytical sensitivity of the selected influenza A antigen detection tests for detection of S-IOV was comparable with that of seasonal influenza H1N1. © 2009 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/78842
ISSN
2015 Impact Factor: 2.647
2015 SCImago Journal Rankings: 1.503
ISI Accession Number ID
Funding AgencyGrant Number
University Grants Committee of the Hong Kong Special Administrative Region, ChinaAoE/M-12/06
Funding Information:

We thank Patrick Lam, Jo Chan, YF Fung and YL Ho for their technical support. This work was supported form a research grant from the University Grants Committee of the Hong Kong Special Administrative Region, China (Project No. AoE/M-12/06).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorChan, KHen_HK
dc.contributor.authorLai, STen_HK
dc.contributor.authorPoon, LLMen_HK
dc.contributor.authorGuan, Yen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.date.accessioned2010-09-06T07:47:29Z-
dc.date.available2010-09-06T07:47:29Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Clinical Virology, 2009, v. 45 n. 3, p. 205-207en_HK
dc.identifier.issn1386-6532en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78842-
dc.description.abstractBackground: A novel swine origin influenza virus (S-OIV) (H1N1) is spreading worldwide and threatens to become pandemic. Objectives: Determine analytical sensitivity of selected commercially available rapid influenza antigen detection tests in detecting S-OIV H1N1. Study design: Serial dilutions of two S-OIV isolates, one seasonal influenza A (H1N1) isolate and a nasopharyngeal aspirate from a patient with S-OIV disease were tested in five commercially available influenza antigen detection tests and by virus isolation in cell culture. Viral M gene copy number was determined by quantitative PCR methods. Results: The analytical sensitivity of the five influenza antigen detection tests for S-OIV (tissue culture infectious dose 50 (TCID50) log10 3.3-4.7 was comparable with that of seasonal influenza (TCID50 log10 4.0-4.5). Conclusion: The analytical sensitivity of the selected influenza A antigen detection tests for detection of S-IOV was comparable with that of seasonal influenza H1N1. © 2009 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jcven_HK
dc.relation.ispartofJournal of Clinical Virologyen_HK
dc.subjectAntigen detectionen_HK
dc.subjectDiagnosticsen_HK
dc.subjectH1N1en_HK
dc.subjectInfluenzaen_HK
dc.subjectPandemicen_HK
dc.subjectPoint-of careen_HK
dc.subject.meshAntigens, Viral - analysis - immunology-
dc.subject.meshImmunoassay - methods-
dc.subject.meshInfluenza A Virus, H1N1 Subtype - immunology - isolation and purification-
dc.subject.meshInfluenza, Human - diagnosis - virology-
dc.subject.meshReassortant Viruses - immunology - isolation and purification-
dc.titleAnalytical sensitivity of rapid influenza antigen detection tests for swine-origin influenza virus (H1N1)en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1386-6532&volume=45&issue=3&spage=205&epage=207&date=2009&atitle=Analytical+sensitivity+of+rapid+influenza+antigen+detection+tests+for+swine-origin+influenza+virus+(H1N1)en_HK
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.authorityPoon, LLM=rp00484en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jcv.2009.05.034en_HK
dc.identifier.pmid19539521-
dc.identifier.scopuseid_2-s2.0-67649220817en_HK
dc.identifier.hkuros164354en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67649220817&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume45en_HK
dc.identifier.issue3en_HK
dc.identifier.spage205en_HK
dc.identifier.epage207en_HK
dc.identifier.isiWOS:000268401800010-
dc.publisher.placeNetherlandsen_HK
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.identifier.scopusauthoridChan, KH=35338760600en_HK
dc.identifier.scopusauthoridLai, ST=7402937038en_HK
dc.identifier.scopusauthoridPoon, LLM=7005441747en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.citeulike5164965-

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