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Article: Antigenic differences between H5N1 human influenza viruses isolated in 1997 and 2003

TitleAntigenic differences between H5N1 human influenza viruses isolated in 1997 and 2003
Authors
KeywordsAntigenicity
H5 influenza virus
Hemagglutinin
Issue Date2004
PublisherJapanese Society of Veterinary Science. The Journal's web site is located at http://wwwsoc.nii.ac.jp/jsvs/03_Journal/Journal-j.html
Citation
Journal Of Veterinary Medical Science, 2004, v. 66 n. 3, p. 303-305 How to Cite?
AbstractTo assess whether the antigenic properties of H5 hemagglutinin (HA) change over time due to antigenic drift, we produced a panel of monoclonal antibodies (mAbs) against the HA of the index H5N1 human influenza A virus, A/Hong Kong/156/97. By immunizing mice with a plasmid expressing this HA and boosting the initial immunization with cell lysates transfected with the plasmid, a total of six hybridomas producing HA-specific mAbs were established: four to the HA1 subunit with hemadsorption-inhibiting activity and two to the HA2 subunit. None of the mAbs to HA1 could bind to the HA of a recent human isolate, A/Hong Kong/213/2003, indicating that there are substantial antigenic differences between the H5N1 human influenza virus isolated in 1997 and that isolated in 2003.
Persistent Identifierhttp://hdl.handle.net/10722/78818
ISSN
2015 Impact Factor: 0.822
2015 SCImago Journal Rankings: 0.539
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHorimoto, Ten_HK
dc.contributor.authorFukuda, Nen_HK
dc.contributor.authorIwatsukiHorimoto, Ken_HK
dc.contributor.authorGuan, Yen_HK
dc.contributor.authorLim, Wen_HK
dc.contributor.authorPeiris, Men_HK
dc.contributor.authorSugii, Sen_HK
dc.contributor.authorOdagiri, Ten_HK
dc.contributor.authorTashiro, Men_HK
dc.contributor.authorKawaoka, Yen_HK
dc.date.accessioned2010-09-06T07:47:11Z-
dc.date.available2010-09-06T07:47:11Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Veterinary Medical Science, 2004, v. 66 n. 3, p. 303-305en_HK
dc.identifier.issn0916-7250en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78818-
dc.description.abstractTo assess whether the antigenic properties of H5 hemagglutinin (HA) change over time due to antigenic drift, we produced a panel of monoclonal antibodies (mAbs) against the HA of the index H5N1 human influenza A virus, A/Hong Kong/156/97. By immunizing mice with a plasmid expressing this HA and boosting the initial immunization with cell lysates transfected with the plasmid, a total of six hybridomas producing HA-specific mAbs were established: four to the HA1 subunit with hemadsorption-inhibiting activity and two to the HA2 subunit. None of the mAbs to HA1 could bind to the HA of a recent human isolate, A/Hong Kong/213/2003, indicating that there are substantial antigenic differences between the H5N1 human influenza virus isolated in 1997 and that isolated in 2003.en_HK
dc.languageengen_HK
dc.publisherJapanese Society of Veterinary Science. The Journal's web site is located at http://wwwsoc.nii.ac.jp/jsvs/03_Journal/Journal-j.htmlen_HK
dc.relation.ispartofJournal of Veterinary Medical Scienceen_HK
dc.subjectAntigenicityen_HK
dc.subjectH5 influenza virusen_HK
dc.subjectHemagglutininen_HK
dc.titleAntigenic differences between H5N1 human influenza viruses isolated in 1997 and 2003en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0916-7250&volume=66&issue=3&spage=303&epage=5&date=2004&atitle=Antigenic+differences+between+H5N1+human+influenza+viruses+isolated+in+1997+and+2003en_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.emailPeiris, M: malik@hkucc.hku.hken_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.identifier.authorityPeiris, M=rp00410en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1292/jvms.66.303en_HK
dc.identifier.pmid15107562-
dc.identifier.scopuseid_2-s2.0-2342453362en_HK
dc.identifier.hkuros87741en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2342453362&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume66en_HK
dc.identifier.issue3en_HK
dc.identifier.spage303en_HK
dc.identifier.epage305en_HK
dc.identifier.isiWOS:000220918600015-
dc.publisher.placeJapanen_HK
dc.identifier.scopusauthoridHorimoto, T=7004547083en_HK
dc.identifier.scopusauthoridFukuda, N=7201603981en_HK
dc.identifier.scopusauthoridIwatsukiHorimoto, K=6603276128en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.scopusauthoridLim, W=7202378277en_HK
dc.identifier.scopusauthoridPeiris, M=7005486823en_HK
dc.identifier.scopusauthoridSugii, S=7006543373en_HK
dc.identifier.scopusauthoridOdagiri, T=7005759915en_HK
dc.identifier.scopusauthoridTashiro, M=7201482415en_HK
dc.identifier.scopusauthoridKawaoka, Y=26643027000en_HK

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