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Article: Caveolin-1 gene is coordinately regulated with the multidrug resistance 1 gene in normal and leukemic bone marrow

TitleCaveolin-1 gene is coordinately regulated with the multidrug resistance 1 gene in normal and leukemic bone marrow
Authors
Issue Date2004
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/leukres
Citation
Leukemia Research, 2004, v. 28 n. 9, p. 973-977 How to Cite?
AbstractCaveolin-1 is a structural protein that may function as a scaffold for plasma membrane proteins, one of which is P-glycoprotein (P-gp), product of the multidrug resistance-1 (MDR-1) gene. We tested the hypothesis that if P-gp and caveolin-1 interacted physically, caveolin-1 and MDR-1 genes might be coordinately regulated; by quantifiying their gene expression with quantitative-polymerase chain reaction. MDR-1 and caveolin-1 gene expressions were normalized to an internal control and related to a fixed calibrator by a comparative cycle-threshold (CT) method. In four different groups of marrow samples (20 normal, 56 acute myeloid leukemias (AML) at diagnosis, 48 AMLs at relapse, and 51 regenerating marrows), caveolin-1 and MDR-1 gene expressions were positively correlated. In 65 samples with MDR-1 over-expression, caveolin-1 and MDR-1 expressions were also correlated. The coordinate expression of caveolin-1 and MDR-1 suggests that they may either interact physically, or are involved in the same aberrant pathway(s) activated during MDR-1 up-regulation. © 2004 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/78783
ISSN
2015 Impact Factor: 2.606
2015 SCImago Journal Rankings: 1.043
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPang, Aen_HK
dc.contributor.authorAu, WYen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T07:46:41Z-
dc.date.available2010-09-06T07:46:41Z-
dc.date.issued2004en_HK
dc.identifier.citationLeukemia Research, 2004, v. 28 n. 9, p. 973-977en_HK
dc.identifier.issn0145-2126en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78783-
dc.description.abstractCaveolin-1 is a structural protein that may function as a scaffold for plasma membrane proteins, one of which is P-glycoprotein (P-gp), product of the multidrug resistance-1 (MDR-1) gene. We tested the hypothesis that if P-gp and caveolin-1 interacted physically, caveolin-1 and MDR-1 genes might be coordinately regulated; by quantifiying their gene expression with quantitative-polymerase chain reaction. MDR-1 and caveolin-1 gene expressions were normalized to an internal control and related to a fixed calibrator by a comparative cycle-threshold (CT) method. In four different groups of marrow samples (20 normal, 56 acute myeloid leukemias (AML) at diagnosis, 48 AMLs at relapse, and 51 regenerating marrows), caveolin-1 and MDR-1 gene expressions were positively correlated. In 65 samples with MDR-1 over-expression, caveolin-1 and MDR-1 expressions were also correlated. The coordinate expression of caveolin-1 and MDR-1 suggests that they may either interact physically, or are involved in the same aberrant pathway(s) activated during MDR-1 up-regulation. © 2004 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/leukresen_HK
dc.relation.ispartofLeukemia Researchen_HK
dc.subject.meshBone Marrow - pathologyen_HK
dc.subject.meshCalibrationen_HK
dc.subject.meshCaveolin 1en_HK
dc.subject.meshCaveolins - biosynthesis - geneticsen_HK
dc.subject.meshDisease Progressionen_HK
dc.subject.meshGene Expression Regulation, Neoplasticen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLeukemia, Myeloid - pathologyen_HK
dc.subject.meshP-Glycoprotein - biosynthesis - geneticsen_HK
dc.subject.meshPolymerase Chain Reaction - methodsen_HK
dc.subject.meshReference Standardsen_HK
dc.titleCaveolin-1 gene is coordinately regulated with the multidrug resistance 1 gene in normal and leukemic bone marrowen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0145-2126&volume=28&issue=9&spage=973&epage=977 &date=2004&atitle=Caveolin-1+gene+is+coordinately+regulated+with+the+multidrug+resistance+1+gene+in+normal+and+leukemic+bone+marrow+en_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.leukres.2004.01.010en_HK
dc.identifier.pmid15234575-
dc.identifier.scopuseid_2-s2.0-3242699515en_HK
dc.identifier.hkuros98156en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3242699515&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue9en_HK
dc.identifier.spage973en_HK
dc.identifier.epage977en_HK
dc.identifier.isiWOS:000222820200013-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridPang, A=7007044165en_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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