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Article: Focal segmental glomerulosclerosis and mesangial sclerosis associated with myeloproliferative disorders

TitleFocal segmental glomerulosclerosis and mesangial sclerosis associated with myeloproliferative disorders
Authors
KeywordsFocal segmental glomerulosclerosis (FSGS)
Myeloproliferative disorders (MPDs)
Issue Date1999
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/ajkd
Citation
American Journal Of Kidney Diseases, 1999, v. 34 n. 5, p. 889-893 How to Cite?
AbstractThe myeloproliferative disorders (MPDs) are clonal disorders of the hematopoietic stem cell and classified as polycythemia vera (PV), essential thrombocythemia (ET), or agnogenic myeloid metaplasia (AMM), depending on the main hematopoietic lineage involved. Primary renal parenchymal lesions are not commonly reported in these cases. We conducted a retrospective analysis of 138 consecutive patients with MPD to determine the frequency of renal parenchymal complications. Five patients (3.6%) (two PV, two ET, one AMM) were found to have focal segmental glomerulosclerosis (FSGS) and diffuse mesangial sclerosis, presenting as proteinuria in all the cases and progressing to chronic renal failure in two cases. A possible common risk factor was a high platelet count, because abnormal platelet activation in MPD has been shown to contribute to the development of glomerulosclerosis. The pathophysiologic basis of our observations and the implications in management of MPD patients remain to be studied.
Persistent Identifierhttp://hdl.handle.net/10722/78748
ISSN
2015 Impact Factor: 6.269
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorChan, KWen_HK
dc.contributor.authorLui, SLen_HK
dc.contributor.authorLam, CCKen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T07:46:18Z-
dc.date.available2010-09-06T07:46:18Z-
dc.date.issued1999en_HK
dc.identifier.citationAmerican Journal Of Kidney Diseases, 1999, v. 34 n. 5, p. 889-893en_HK
dc.identifier.issn0272-6386en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78748-
dc.description.abstractThe myeloproliferative disorders (MPDs) are clonal disorders of the hematopoietic stem cell and classified as polycythemia vera (PV), essential thrombocythemia (ET), or agnogenic myeloid metaplasia (AMM), depending on the main hematopoietic lineage involved. Primary renal parenchymal lesions are not commonly reported in these cases. We conducted a retrospective analysis of 138 consecutive patients with MPD to determine the frequency of renal parenchymal complications. Five patients (3.6%) (two PV, two ET, one AMM) were found to have focal segmental glomerulosclerosis (FSGS) and diffuse mesangial sclerosis, presenting as proteinuria in all the cases and progressing to chronic renal failure in two cases. A possible common risk factor was a high platelet count, because abnormal platelet activation in MPD has been shown to contribute to the development of glomerulosclerosis. The pathophysiologic basis of our observations and the implications in management of MPD patients remain to be studied.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/ajkden_HK
dc.relation.ispartofAmerican Journal of Kidney Diseasesen_HK
dc.subjectFocal segmental glomerulosclerosis (FSGS)en_HK
dc.subjectMyeloproliferative disorders (MPDs)en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshBiopsyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGlomerular Mesangium - pathologyen_HK
dc.subject.meshGlomerulosclerosis, Focal Segmental - pathologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshKidney Glomerulus - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMyeloproliferative Disorders - pathologyen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.titleFocal segmental glomerulosclerosis and mesangial sclerosis associated with myeloproliferative disordersen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0272-6386&volume=34&spage=889&epage=893&date=1999&atitle=Focal+segmental+glomerulosclerosis+and+mesangial+sclerosis+associated+with+myeloproliferative+disordersen_HK
dc.identifier.emailChan, KW:hrmtckw@hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityChan, KW=rp00330en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10561146-
dc.identifier.scopuseid_2-s2.0-0032730593en_HK
dc.identifier.hkuros47765en_HK
dc.identifier.volume34en_HK
dc.identifier.issue5en_HK
dc.identifier.spage889en_HK
dc.identifier.epage893en_HK
dc.identifier.isiWOS:000083545500015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridChan, KW=16444133100en_HK
dc.identifier.scopusauthoridLui, SL=7102379130en_HK
dc.identifier.scopusauthoridLam, CCK=16947291300en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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