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Article: Variability of the prevalence of undiagnosed airflow obstruction in smokers using different diagnostic criteria

TitleVariability of the prevalence of undiagnosed airflow obstruction in smokers using different diagnostic criteria
Authors
Issue Date2008
PublisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.org
Citation
Chest, 2008, v. 133 n. 1, p. 42-48 How to Cite?
AbstractPurpose: To estimate the prevalence of undiagnosed airflow obstruction (AFO) in Hong Kong smokers with no previous diagnosis of respiratory disease, and to assess its variability when applying different prediction equations and diagnostic criteria. Methods: A multicenter, population-based, cross-sectional prevalence study was performed in smokers aged 20 to 80 years. Three different criteria (fixed 70% [Global Initiative for Chronic Obstructive Lung Disease and British Thoracic Society], fixed 75%, and European Respiratory Society [ERS]) were applied to define a lower limit of normal (LLN) of the FEV 1/FVC ratio to compare with the Hong Kong Chinese reference equation (criterion 1), which had used a distribution-free method to obtain the lower fifth percentile of FEV 1/FVC ratio as the LLN. Results: In 525 male patients, using criterion 1 (local internal prediction equation) and defining AFO as FEV 1/FVC less than LLN, the overall prevalence of AFO was 13.7%: 8.3% in age ≥ 20 to 40 years, 14.0% in age ≥ 40 to 60 years, and 17.8% in age ≥ 60 to 80 years. When the local internal prediction equation was used as the comparison reference, the fixed-ratio methods tended to miss AFO in younger age groups and overdiagnose AFO in old age, while the ERS criteria, which uses an almost lower fifth percentile-equivalent method, showed less of such a trend but still only showed moderate agreement with criterion 1. Conclusions: Undiagnosed AFO was prevalent in Hong Kong smokers. Estimated prevalence rates were highly affected by the criteria used to define AFO. The predicted lower fifth percentile values calculated from a local reference equation as the LLN of FEV 1/FVC ratio should be used for the diagnosis of AFO.
Persistent Identifierhttp://hdl.handle.net/10722/78706
ISSN
2015 Impact Factor: 5.94
2015 SCImago Journal Rankings: 3.176
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLau, ACWen_HK
dc.contributor.authorIp, MSMen_HK
dc.contributor.authorLai, CKWen_HK
dc.contributor.authorChoo, KLen_HK
dc.contributor.authorTang, KSen_HK
dc.contributor.authorYam, LYCen_HK
dc.contributor.authorChanYeung, Men_HK
dc.date.accessioned2010-09-06T07:45:50Z-
dc.date.available2010-09-06T07:45:50Z-
dc.date.issued2008en_HK
dc.identifier.citationChest, 2008, v. 133 n. 1, p. 42-48en_HK
dc.identifier.issn0012-3692en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78706-
dc.description.abstractPurpose: To estimate the prevalence of undiagnosed airflow obstruction (AFO) in Hong Kong smokers with no previous diagnosis of respiratory disease, and to assess its variability when applying different prediction equations and diagnostic criteria. Methods: A multicenter, population-based, cross-sectional prevalence study was performed in smokers aged 20 to 80 years. Three different criteria (fixed 70% [Global Initiative for Chronic Obstructive Lung Disease and British Thoracic Society], fixed 75%, and European Respiratory Society [ERS]) were applied to define a lower limit of normal (LLN) of the FEV 1/FVC ratio to compare with the Hong Kong Chinese reference equation (criterion 1), which had used a distribution-free method to obtain the lower fifth percentile of FEV 1/FVC ratio as the LLN. Results: In 525 male patients, using criterion 1 (local internal prediction equation) and defining AFO as FEV 1/FVC less than LLN, the overall prevalence of AFO was 13.7%: 8.3% in age ≥ 20 to 40 years, 14.0% in age ≥ 40 to 60 years, and 17.8% in age ≥ 60 to 80 years. When the local internal prediction equation was used as the comparison reference, the fixed-ratio methods tended to miss AFO in younger age groups and overdiagnose AFO in old age, while the ERS criteria, which uses an almost lower fifth percentile-equivalent method, showed less of such a trend but still only showed moderate agreement with criterion 1. Conclusions: Undiagnosed AFO was prevalent in Hong Kong smokers. Estimated prevalence rates were highly affected by the criteria used to define AFO. The predicted lower fifth percentile values calculated from a local reference equation as the LLN of FEV 1/FVC ratio should be used for the diagnosis of AFO.en_HK
dc.languageengen_HK
dc.publisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.orgen_HK
dc.relation.ispartofChesten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshCross-Sectional Studiesen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLung Diseases, Obstructive - diagnosis - epidemiology - etiologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPrevalenceen_HK
dc.subject.meshSmoking - adverse effectsen_HK
dc.titleVariability of the prevalence of undiagnosed airflow obstruction in smokers using different diagnostic criteriaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0012-3692&volume=133&spage=42&epage=48&date=2008&atitle=Variability+of+the+prevalence+of+undiagnosed+airflow+obstruction+in+smokers+using+different+diagnostic+criteriaen_HK
dc.identifier.emailIp, MSM:msmip@hku.hken_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1378/chest.07-1434en_HK
dc.identifier.pmid17989159-
dc.identifier.scopuseid_2-s2.0-38349022418en_HK
dc.identifier.hkuros149906en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38349022418&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume133en_HK
dc.identifier.issue1en_HK
dc.identifier.spage42en_HK
dc.identifier.epage48en_HK
dc.identifier.isiWOS:000252385600011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLau, ACW=7202626205en_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK
dc.identifier.scopusauthoridLai, CKW=24466535800en_HK
dc.identifier.scopusauthoridChoo, KL=23391819100en_HK
dc.identifier.scopusauthoridTang, KS=15065968800en_HK
dc.identifier.scopusauthoridYam, LYC=7102764741en_HK
dc.identifier.scopusauthoridChanYeung, M=54790582200en_HK

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