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Article: Molecular pathways in hepatocellular carcinoma

TitleMolecular pathways in hepatocellular carcinoma
Authors
KeywordsGenetic aberrations
HBx protein
Hepatitis B virus
Hepatitis C virus
Hepatocellular carcinoma
Issue Date2006
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2006, v. 240 n. 2, p. 157-169 How to Cite?
AbstractResearch over the past decade has unraveled important molecular pathways involved in hepatocellular carcinoma (HCC), and several chromosomal and genetic aberrations have been identified to be responsible for initiation of the carcinogenic process. HBx protein and HCV core protein appear to play a pivotal role in hepatocarcinogenesis related to hepatitis B virus and hepatitis C virus, respectively. These viral oncoproteins allow cells to bypass some of the multi-steps in hepatocarcinogenesis, accounting for the etiological role of the two viruses in HCC. Understanding of the molecular pathways of HCC facilitates the development of novel molecular strategies for chemoprevention and therapy of HCC. © 2005 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/78662
ISSN
2015 Impact Factor: 5.992
2015 SCImago Journal Rankings: 2.331
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPang, Ren_HK
dc.contributor.authorTse, Een_HK
dc.contributor.authorPoon, RTPen_HK
dc.date.accessioned2010-09-06T07:45:21Z-
dc.date.available2010-09-06T07:45:21Z-
dc.date.issued2006en_HK
dc.identifier.citationCancer Letters, 2006, v. 240 n. 2, p. 157-169en_HK
dc.identifier.issn0304-3835en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78662-
dc.description.abstractResearch over the past decade has unraveled important molecular pathways involved in hepatocellular carcinoma (HCC), and several chromosomal and genetic aberrations have been identified to be responsible for initiation of the carcinogenic process. HBx protein and HCV core protein appear to play a pivotal role in hepatocarcinogenesis related to hepatitis B virus and hepatitis C virus, respectively. These viral oncoproteins allow cells to bypass some of the multi-steps in hepatocarcinogenesis, accounting for the etiological role of the two viruses in HCC. Understanding of the molecular pathways of HCC facilitates the development of novel molecular strategies for chemoprevention and therapy of HCC. © 2005 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_HK
dc.relation.ispartofCancer Lettersen_HK
dc.rightsCancer Letters . Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectGenetic aberrationsen_HK
dc.subjectHBx proteinen_HK
dc.subjectHepatitis B virusen_HK
dc.subjectHepatitis C virusen_HK
dc.subjectHepatocellular carcinomaen_HK
dc.subject.meshCarcinoma, Hepatocellular - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver Neoplasms - geneticsen_HK
dc.subject.meshSignal Transduction - geneticsen_HK
dc.titleMolecular pathways in hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3835&volume=240&issue=2&spage=157&epage=169&date=2006&atitle=Molecular+pathways+in+hepatocellular+carcinomaen_HK
dc.identifier.emailPang, R: robertap@hkucc.hku.hken_HK
dc.identifier.emailTse, E: ewctse@hku.hken_HK
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_HK
dc.identifier.authorityPang, R=rp00274en_HK
dc.identifier.authorityTse, E=rp00471en_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.canlet.2005.08.031en_HK
dc.identifier.pmid16239065-
dc.identifier.scopuseid_2-s2.0-33746268320en_HK
dc.identifier.hkuros122746en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746268320&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume240en_HK
dc.identifier.issue2en_HK
dc.identifier.spage157en_HK
dc.identifier.epage169en_HK
dc.identifier.isiWOS:000240418200001-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridPang, R=7004376659en_HK
dc.identifier.scopusauthoridTse, E=7005019454en_HK
dc.identifier.scopusauthoridPoon, RTP=7103097223en_HK

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