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Article: Stem cell model of hematopoiesis.

TitleStem cell model of hematopoiesis.
Authors
Issue Date2006
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cscrt/index.htm
Citation
Current Stem Cell Research & Therapy, 2006, v. 1 n. 3, p. 305-315 How to Cite?
AbstractHematopoietic stem cells (HSC) are characterized by their capacity of self-renewal, multi-lineage differentiation, and the ability to rescue lethally irradiated hosts. Both murine and human studies have attempted to characterize and purify HSC based on surface phenotypes, metabolic markers, in-vitro clonogenic and in-vivo competitive repopulation assays. The cell-fate of HSC is under intrinsic regulation by various transcription factors, including Hox and SCL genes, cyclin-dependent kinase inhibitors and telomerase, and extrinsic regulation by various signaling pathways involved in embryonic development, including the Notch, Wnt and bone morphogenetic proteins (BMP) pathways. Recent advances in genome research and gene profiling technologies have begun to unravel the regulatory mechanism of HSC by novel genes with hitherto unknown functions in hematopoiesis. The stem cell model of hematopoiesis has also shed light on the concepts of leukemic stem cells (LSC), which involves the presence of a rare population of cells that share the essential HSC attributes of self-renewing, replication and differentiation into progenies of leukemic blasts.
Persistent Identifierhttp://hdl.handle.net/10722/78651
ISSN
2015 Impact Factor: 2.645
2015 SCImago Journal Rankings: 0.869

 

DC FieldValueLanguage
dc.contributor.authorCheung, AMen_HK
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorLeung, AYen_HK
dc.date.accessioned2010-09-06T07:45:14Z-
dc.date.available2010-09-06T07:45:14Z-
dc.date.issued2006en_HK
dc.identifier.citationCurrent Stem Cell Research & Therapy, 2006, v. 1 n. 3, p. 305-315en_HK
dc.identifier.issn1574-888Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/78651-
dc.description.abstractHematopoietic stem cells (HSC) are characterized by their capacity of self-renewal, multi-lineage differentiation, and the ability to rescue lethally irradiated hosts. Both murine and human studies have attempted to characterize and purify HSC based on surface phenotypes, metabolic markers, in-vitro clonogenic and in-vivo competitive repopulation assays. The cell-fate of HSC is under intrinsic regulation by various transcription factors, including Hox and SCL genes, cyclin-dependent kinase inhibitors and telomerase, and extrinsic regulation by various signaling pathways involved in embryonic development, including the Notch, Wnt and bone morphogenetic proteins (BMP) pathways. Recent advances in genome research and gene profiling technologies have begun to unravel the regulatory mechanism of HSC by novel genes with hitherto unknown functions in hematopoiesis. The stem cell model of hematopoiesis has also shed light on the concepts of leukemic stem cells (LSC), which involves the presence of a rare population of cells that share the essential HSC attributes of self-renewing, replication and differentiation into progenies of leukemic blasts.en_HK
dc.languageengen_HK
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cscrt/index.htmen_HK
dc.relation.ispartofCurrent stem cell research & therapyen_HK
dc.subject.meshEmbryo, Mammalian - physiology-
dc.subject.meshHematopoiesis-
dc.subject.meshHematopoietic Stem Cells - cytology - physiology-
dc.subject.meshSheep - embryology-
dc.subject.meshStem Cells - chemistry - physiology-
dc.titleStem cell model of hematopoiesis.en_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, AM:h9945256@graduate.hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.emailLeung, AY:ayhleung@hku.hken_HK
dc.identifier.authorityCheung, AM=rp01572en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.identifier.authorityLeung, AY=rp00265en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid18220875-
dc.identifier.scopuseid_2-s2.0-39649112197en_HK
dc.identifier.hkuros136011en_HK
dc.identifier.hkuros199385-
dc.identifier.volume1en_HK
dc.identifier.issue3en_HK
dc.identifier.spage305en_HK
dc.identifier.epage315en_HK
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridCheung, AM=36985759800en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridLeung, AY=7403012668en_HK

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