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Article: Genetics of osteoporosis

TitleGenetics of osteoporosis
Authors
KeywordsAssociation
Bone mineral density
Genetics
Linkage
Osteoporosis
Issue Date2006
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ymgme
Citation
Molecular Genetics And Metabolism, 2006, v. 88 n. 4, p. 295-306 How to Cite?
AbstractOsteoporosis is a common disease with a strong genetic component. In recent years, some progress has been made in understanding the genetic basis of osteoporosis. Genetic factors contribute to osteoporosis by influencing not only bone mineral density but also bone size, bone quality, and bone turnover. Meta-analysis has been used to define the role of several candidate genes in osteoporosis. Some quantitative trait loci that regulate bone mass identified by linkage studies in humans and experimental animals have been replicated in multiple populations. Genes that cause monogenic bone diseases also contribute to regulation of bone mass in the normal population. Genome-wide association studies and functional genomics approaches have recently begun to apply to genetic studies of osteoporosis. In the future, not only single gene but also the entire gene networks involved in osteoporosis and regulation of bone mass will systematically be discovered through integrative genomics. © 2006 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/78616
ISSN
2015 Impact Factor: 3.093
2015 SCImago Journal Rankings: 1.520
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHuang, QYen_HK
dc.contributor.authorKung, AWCen_HK
dc.date.accessioned2010-09-06T07:44:51Z-
dc.date.available2010-09-06T07:44:51Z-
dc.date.issued2006en_HK
dc.identifier.citationMolecular Genetics And Metabolism, 2006, v. 88 n. 4, p. 295-306en_HK
dc.identifier.issn1096-7192en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78616-
dc.description.abstractOsteoporosis is a common disease with a strong genetic component. In recent years, some progress has been made in understanding the genetic basis of osteoporosis. Genetic factors contribute to osteoporosis by influencing not only bone mineral density but also bone size, bone quality, and bone turnover. Meta-analysis has been used to define the role of several candidate genes in osteoporosis. Some quantitative trait loci that regulate bone mass identified by linkage studies in humans and experimental animals have been replicated in multiple populations. Genes that cause monogenic bone diseases also contribute to regulation of bone mass in the normal population. Genome-wide association studies and functional genomics approaches have recently begun to apply to genetic studies of osteoporosis. In the future, not only single gene but also the entire gene networks involved in osteoporosis and regulation of bone mass will systematically be discovered through integrative genomics. © 2006 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ymgmeen_HK
dc.relation.ispartofMolecular Genetics and Metabolismen_HK
dc.subjectAssociationen_HK
dc.subjectBone mineral densityen_HK
dc.subjectGeneticsen_HK
dc.subjectLinkageen_HK
dc.subjectOsteoporosisen_HK
dc.subject.meshBone Density - genetics-
dc.subject.meshGenetic Linkage-
dc.subject.meshGenomics-
dc.subject.meshOsteoporosis - genetics - physiopathology-
dc.subject.meshPhenotype-
dc.titleGenetics of osteoporosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1096-7192&volume=88&issue=4&spage=295&epage=306&date=2006&atitle=Genetics+of+osteoporosisen_HK
dc.identifier.emailHuang, QY: qyhuang@hotmail.comen_HK
dc.identifier.emailKung, AWC: awckung@hku.hken_HK
dc.identifier.authorityHuang, QY=rp00521en_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ymgme.2006.04.009en_HK
dc.identifier.pmid16762578-
dc.identifier.scopuseid_2-s2.0-33746277560en_HK
dc.identifier.hkuros118425en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746277560&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume88en_HK
dc.identifier.issue4en_HK
dc.identifier.spage295en_HK
dc.identifier.epage306en_HK
dc.identifier.isiWOS:000240029700001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHuang, QY=7403630787en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK

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