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Article: Increased circulating inflammatory proteins predict a worse prognosis with valvular calcification in end-stage renal disease: A prospective cohort study

TitleIncreased circulating inflammatory proteins predict a worse prognosis with valvular calcification in end-stage renal disease: A prospective cohort study
Authors
Issue Date2008
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/AJN
Citation
American Journal Of Nephrology, 2008, v. 28 n. 4, p. 647-653 How to Cite?
AbstractBackground: It remains unknown whether inflammation may predict a worse prognosis with valvular calcification (VC) in end-stage renal disease (ESRD) patients. Method: We prospectively performed echocardiography in 231 ESRD patients receiving chronic peritoneal dialysis treatment to detect VC and then followed them for 3 years or until death. Results: Patients with VC had higher C-reactive protein (CRP; p = 0.001), higher interleukin-6 (IL-6; p = 0.002) and lower fetuin-A (p = 0.004). Stratifying patients into 4 groups on the basis of VC, CRP, IL-6 and fetuin-A, respectively, those with VC and CRP in the upper tertile had 3.68-fold (95% confidence intervals [CI], 1.72-7.88; p = 0.001) and 3.13-fold (95% CI, 1.57-6.24; p = 0.001) respective increases in the adjusted risk of mortality and major adverse cardiovascular event (MACE) than those with no VC and CRP in the lower/middle tertiles. The adjusted hazard ratios (HR) in relation to mortality and MACE were 3.56 (95% CI, 1.53-8.26; p = 0.003) and 2.51 (95% CI, 1.24-5.11; p = 0.011), respectively, for patients with VC and IL-6 in the upper tertile compared to those with no VC and IL-6 in the lower/middle tertiles. The adjusted HR in relation to mortality and MACE were 3.56 (95% CI, 1.53-8.26; p = 0.003) and 2.51 (95% CI, 1.24-5.11; p = 0.011), respectively, for patients with VC and fetuin-A in the lower tertile compared to those with no VC and fetuin-A in the middle/upper tertiles. Conclusions: Increased circulating inflammatory proteins predict a worse prognosis of VC in chronic peritoneal dialysis patients. Copyright © 2008 S. Karger AG.
Persistent Identifierhttp://hdl.handle.net/10722/78571
ISSN
2015 Impact Factor: 2.605
2015 SCImago Journal Rankings: 1.308
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, AYMen_HK
dc.contributor.authorLam, CWKen_HK
dc.contributor.authorWang, Men_HK
dc.contributor.authorChan, IHSen_HK
dc.contributor.authorYu, CMen_HK
dc.contributor.authorLui, SFen_HK
dc.contributor.authorSanderson, JEen_HK
dc.date.accessioned2010-09-06T07:44:21Z-
dc.date.available2010-09-06T07:44:21Z-
dc.date.issued2008en_HK
dc.identifier.citationAmerican Journal Of Nephrology, 2008, v. 28 n. 4, p. 647-653en_HK
dc.identifier.issn0250-8095en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78571-
dc.description.abstractBackground: It remains unknown whether inflammation may predict a worse prognosis with valvular calcification (VC) in end-stage renal disease (ESRD) patients. Method: We prospectively performed echocardiography in 231 ESRD patients receiving chronic peritoneal dialysis treatment to detect VC and then followed them for 3 years or until death. Results: Patients with VC had higher C-reactive protein (CRP; p = 0.001), higher interleukin-6 (IL-6; p = 0.002) and lower fetuin-A (p = 0.004). Stratifying patients into 4 groups on the basis of VC, CRP, IL-6 and fetuin-A, respectively, those with VC and CRP in the upper tertile had 3.68-fold (95% confidence intervals [CI], 1.72-7.88; p = 0.001) and 3.13-fold (95% CI, 1.57-6.24; p = 0.001) respective increases in the adjusted risk of mortality and major adverse cardiovascular event (MACE) than those with no VC and CRP in the lower/middle tertiles. The adjusted hazard ratios (HR) in relation to mortality and MACE were 3.56 (95% CI, 1.53-8.26; p = 0.003) and 2.51 (95% CI, 1.24-5.11; p = 0.011), respectively, for patients with VC and IL-6 in the upper tertile compared to those with no VC and IL-6 in the lower/middle tertiles. The adjusted HR in relation to mortality and MACE were 3.56 (95% CI, 1.53-8.26; p = 0.003) and 2.51 (95% CI, 1.24-5.11; p = 0.011), respectively, for patients with VC and fetuin-A in the lower tertile compared to those with no VC and fetuin-A in the middle/upper tertiles. Conclusions: Increased circulating inflammatory proteins predict a worse prognosis of VC in chronic peritoneal dialysis patients. Copyright © 2008 S. Karger AG.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/AJNen_HK
dc.relation.ispartofAmerican Journal of Nephrologyen_HK
dc.rightsAmerican Journal of Nephrology . Copyright © S Karger AG.en_HK
dc.subject.meshC-Reactive Protein - analysisen_HK
dc.subject.meshCalcinosis - pathologyen_HK
dc.subject.meshCardiovascular Diseases - blooden_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHeart Valves - pathologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInterleukin-6 - blooden_HK
dc.subject.meshKidney Failure, Chronic - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPeritoneal Dialysisen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshalpha-Fetoproteins - analysisen_HK
dc.titleIncreased circulating inflammatory proteins predict a worse prognosis with valvular calcification in end-stage renal disease: A prospective cohort studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0250-8095&volume=28&issue=4&spage=647&epage=653&date=2008&atitle=Increased+Circulating+Inflammatory+Proteins+Predict+a+Worse+Prognosis+with+Valvular+Calcification+in+End-Stage+Renal+Disease:+A+Prospective+Cohort+Studyen_HK
dc.identifier.emailWang, M:meiwang@hkucc.hku.hken_HK
dc.identifier.authorityWang, M=rp00281en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000117817en_HK
dc.identifier.pmid18292652-
dc.identifier.scopuseid_2-s2.0-45149124817en_HK
dc.identifier.hkuros155821en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-45149124817&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue4en_HK
dc.identifier.spage647en_HK
dc.identifier.epage653en_HK
dc.identifier.isiWOS:000255896200014-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridWang, AYM=13606226000en_HK
dc.identifier.scopusauthoridLam, CWK=8531362100en_HK
dc.identifier.scopusauthoridWang, M=7406690398en_HK
dc.identifier.scopusauthoridChan, IHS=8298775100en_HK
dc.identifier.scopusauthoridYu, CM=7404976646en_HK
dc.identifier.scopusauthoridLui, SF=36909925000en_HK
dc.identifier.scopusauthoridSanderson, JE=7202371250en_HK

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