File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Protective role of cyclooxygenase inhibitors in the adverse action of passive cigarette smoking on the initiation of experimental colitis in rats

TitleProtective role of cyclooxygenase inhibitors in the adverse action of passive cigarette smoking on the initiation of experimental colitis in rats
Authors
Issue Date2001
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 2001, v. 411 n. 1-2, p. 193-203 How to Cite?
AbstractClinical and experimental findings had indicated that cigarette smoke exposure, and cyclooxygenase-2, are strongly associated with inflammatory bowel disease. The present study aimed to evaluate the role of cyclooxygenase-2 in the pathogenesis of experimental inflammatory bowel disease as well as in the adverse action of cigarette-smoke exposure. Rats were pretreated with different cyclooxygenase-2 inhibitors (indomethacin, nimesulide, or SC-236 (4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonam ide)) along with cigarette-smoke exposure before 2,4,6-trinitrobenzenesulfonic acid-enema. Results indicated that pretreatment with cyclooxygenase-2 inhibitors not only protected against 2,4,6-trinitrobenzenesulfonic acid-induced inflammatory bowel disease, but also attenuated the potentiating effect of cigarette-smoke exposure on colonic damage. Furthermore, the colonic cyclooxygenase-2 protein and mRNA expression was markedly induced by 2,4,6-trinitrobenzenesulfonic acid-enema, and it was potentiated further by cigarette-smoke exposure, while the cyclooxygenase-1 expression was not changed. The present study suggests that the highly induced cyclooxygenase-2 expression not only plays a pathogenic role in 2,4,6-trinitrobenzenesulfonic acid-induced inflammatory bowel disease, but also contributes to the adverse action of cigarette-smoke exposure on this disorder. © 2001 Elsevier Science B.V.
Persistent Identifierhttp://hdl.handle.net/10722/78561
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGuo, Xen_HK
dc.contributor.authorLiu, ESLen_HK
dc.contributor.authorKo, JKSen_HK
dc.contributor.authorWong, BCYen_HK
dc.contributor.authorYe, YNen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorCho, CHen_HK
dc.date.accessioned2010-09-06T07:44:14Z-
dc.date.available2010-09-06T07:44:14Z-
dc.date.issued2001en_HK
dc.identifier.citationEuropean Journal Of Pharmacology, 2001, v. 411 n. 1-2, p. 193-203en_HK
dc.identifier.issn0014-2999en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78561-
dc.description.abstractClinical and experimental findings had indicated that cigarette smoke exposure, and cyclooxygenase-2, are strongly associated with inflammatory bowel disease. The present study aimed to evaluate the role of cyclooxygenase-2 in the pathogenesis of experimental inflammatory bowel disease as well as in the adverse action of cigarette-smoke exposure. Rats were pretreated with different cyclooxygenase-2 inhibitors (indomethacin, nimesulide, or SC-236 (4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonam ide)) along with cigarette-smoke exposure before 2,4,6-trinitrobenzenesulfonic acid-enema. Results indicated that pretreatment with cyclooxygenase-2 inhibitors not only protected against 2,4,6-trinitrobenzenesulfonic acid-induced inflammatory bowel disease, but also attenuated the potentiating effect of cigarette-smoke exposure on colonic damage. Furthermore, the colonic cyclooxygenase-2 protein and mRNA expression was markedly induced by 2,4,6-trinitrobenzenesulfonic acid-enema, and it was potentiated further by cigarette-smoke exposure, while the cyclooxygenase-1 expression was not changed. The present study suggests that the highly induced cyclooxygenase-2 expression not only plays a pathogenic role in 2,4,6-trinitrobenzenesulfonic acid-induced inflammatory bowel disease, but also contributes to the adverse action of cigarette-smoke exposure on this disorder. © 2001 Elsevier Science B.V.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_HK
dc.relation.ispartofEuropean Journal of Pharmacologyen_HK
dc.rightsEuropean Journal of Pharmacology. Copyright © Elsevier BV.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBlotting, Westernen_HK
dc.subject.meshColitis - enzymology - etiology - prevention & controlen_HK
dc.subject.meshColon - drug effects - metabolism - pathologyen_HK
dc.subject.meshCyclooxygenase 1en_HK
dc.subject.meshCyclooxygenase 2en_HK
dc.subject.meshCyclooxygenase 2 Inhibitorsen_HK
dc.subject.meshCyclooxygenase Inhibitors - pharmacologyen_HK
dc.subject.meshGene Expression Regulation, Enzymologic - drug effectsen_HK
dc.subject.meshIndomethacin - pharmacologyen_HK
dc.subject.meshInflammation - enzymology - prevention & controlen_HK
dc.subject.meshInflammatory Bowel Diseases - chemically induced - enzymology - prevention & controlen_HK
dc.subject.meshIsoenzymes - antagonists & inhibitors - genetics - metabolismen_HK
dc.subject.meshLeukotriene B4 - metabolismen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMembrane Proteinsen_HK
dc.subject.meshPeroxidase - drug effects - metabolismen_HK
dc.subject.meshProstaglandin-Endoperoxide Synthases - genetics - metabolismen_HK
dc.subject.meshProstaglandins - biosynthesisen_HK
dc.subject.meshRNA, Messenger - drug effects - genetics - metabolismen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.subject.meshSulfonamides - pharmacologyen_HK
dc.subject.meshTobacco Smoke Pollution - adverse effectsen_HK
dc.subject.meshTrinitrobenzenesulfonic Acid - administration & dosageen_HK
dc.titleProtective role of cyclooxygenase inhibitors in the adverse action of passive cigarette smoking on the initiation of experimental colitis in ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0014-2999&volume=411&spage=193&epage=203&date=2000&atitle=Protective+role+of+cyclooxygenase+inhibitors+in+the+adverse+action+of+passive+cigarette+smoking+on+the+initiation+of+experimental+colitis+in+ratsen_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0014-2999(00)00914-6en_HK
dc.identifier.pmid11137876-
dc.identifier.scopuseid_2-s2.0-0035179765en_HK
dc.identifier.hkuros58831en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035179765&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume411en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage193en_HK
dc.identifier.epage203en_HK
dc.identifier.isiWOS:000166489600025-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridGuo, X=55202826300en_HK
dc.identifier.scopusauthoridLiu, ESL=7202240071en_HK
dc.identifier.scopusauthoridKo, JKS=7402678571en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.scopusauthoridYe, YN=7401627402en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK
dc.identifier.scopusauthoridCho, CH=7403100461en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats