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Article: Serum nitric oxide metabolites and disease activity in patients with systemic sclerosis

TitleSerum nitric oxide metabolites and disease activity in patients with systemic sclerosis
Authors
KeywordsInflammation
Interstitial lung disease
Nitric oxide synthase
Systemic sclerosis
Issue Date2008
PublisherSpringer-Verlag London Ltd. The Journal's web site is located at http://link.springer.de/link/service/journals/10067/
Citation
Clinical Rheumatology, 2008, v. 27 n. 3, p. 315-322 How to Cite?
AbstractThere is no surrogate marker in serum for defining disease activity in scleroderma (SSc). Nitric oxide (NO), which regulates vasodilation and possesses pro-inflammatory actions, has been implicated in the pathogenesis of SSc. We compared serum NO x (total nitrate and nitrite) level in SSc patients to healthy controls and evaluated its correlation with detailed symptomatology and scoring systems for various organ involvement. Symptoms and physical findings that suggested disease activity in regard to various organs were documented. Lung function test, high-resolution computed tomographic (HRCT) scan of thorax and echocardiography were performed. Serum NO x was measured by chemiluminescence. Serum NO x levels in SSc (n=43) were significantly higher (72.4±47.8 μM) than age- and sex-matched controls (n=41; 37.1±13.5 μM; p<0.001). Serum NO x were not found to be associated with lung fibrosis defined by lung function parameters or inflammation and fibrosis scores on HRCT. Twenty-two patients were found to have elevated serum NO x level defined as mean ± 2 SD of normal controls. Logistic regression analysis revealed that age (OR 1.12, p=0.02) and elevated pulmonary arterial pressure (PAP) (n=9; OR 145.3, p=0.01) were predictive factors for elevated serum NO x . Prednisolone use was associated with lower serum NO x level (OR 0.06, p=0.04). Elevated PAP of increasing severity was found to be associated with higher level of serum NO x (p=0.004 by trend). Serum NO x in SSc patients were elevated compared to healthy controls. Serum NO x level was determined by multiple factors including age, prednisolone use, and elevated PAP. © 2007 Clinical Rheumatology.
Persistent Identifierhttp://hdl.handle.net/10722/78548
ISSN
2015 Impact Factor: 2.042
2015 SCImago Journal Rankings: 0.697
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMok, MYen_HK
dc.contributor.authorFung, PCWen_HK
dc.contributor.authorOoi, Cen_HK
dc.contributor.authorTse, HFen_HK
dc.contributor.authorWong, Yen_HK
dc.contributor.authorLam, YMen_HK
dc.contributor.authorWong, WSen_HK
dc.contributor.authorLau, CSen_HK
dc.date.accessioned2010-09-06T07:44:06Z-
dc.date.available2010-09-06T07:44:06Z-
dc.date.issued2008en_HK
dc.identifier.citationClinical Rheumatology, 2008, v. 27 n. 3, p. 315-322en_HK
dc.identifier.issn0770-3198en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78548-
dc.description.abstractThere is no surrogate marker in serum for defining disease activity in scleroderma (SSc). Nitric oxide (NO), which regulates vasodilation and possesses pro-inflammatory actions, has been implicated in the pathogenesis of SSc. We compared serum NO x (total nitrate and nitrite) level in SSc patients to healthy controls and evaluated its correlation with detailed symptomatology and scoring systems for various organ involvement. Symptoms and physical findings that suggested disease activity in regard to various organs were documented. Lung function test, high-resolution computed tomographic (HRCT) scan of thorax and echocardiography were performed. Serum NO x was measured by chemiluminescence. Serum NO x levels in SSc (n=43) were significantly higher (72.4±47.8 μM) than age- and sex-matched controls (n=41; 37.1±13.5 μM; p<0.001). Serum NO x were not found to be associated with lung fibrosis defined by lung function parameters or inflammation and fibrosis scores on HRCT. Twenty-two patients were found to have elevated serum NO x level defined as mean ± 2 SD of normal controls. Logistic regression analysis revealed that age (OR 1.12, p=0.02) and elevated pulmonary arterial pressure (PAP) (n=9; OR 145.3, p=0.01) were predictive factors for elevated serum NO x . Prednisolone use was associated with lower serum NO x level (OR 0.06, p=0.04). Elevated PAP of increasing severity was found to be associated with higher level of serum NO x (p=0.004 by trend). Serum NO x in SSc patients were elevated compared to healthy controls. Serum NO x level was determined by multiple factors including age, prednisolone use, and elevated PAP. © 2007 Clinical Rheumatology.en_HK
dc.languageengen_HK
dc.publisherSpringer-Verlag London Ltd. The Journal's web site is located at http://link.springer.de/link/service/journals/10067/en_HK
dc.relation.ispartofClinical Rheumatologyen_HK
dc.subjectInflammationen_HK
dc.subjectInterstitial lung diseaseen_HK
dc.subjectNitric oxide synthaseen_HK
dc.subjectSystemic sclerosisen_HK
dc.titleSerum nitric oxide metabolites and disease activity in patients with systemic sclerosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0770-3198&volume=27&spage=315&epage=322&date=2007&atitle=Serum+Nitric+Oxide+Metabolites+and+Disease+Activity+in+Patients+with+Systemic+Sclerosisen_HK
dc.identifier.emailMok, MY:temy@hkucc.hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.emailLau, CS:cslau@hku.hken_HK
dc.identifier.authorityMok, MY=rp00490en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s10067-007-0708-9en_HK
dc.identifier.scopuseid_2-s2.0-41949135420en_HK
dc.identifier.hkuros134686en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-41949135420&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue3en_HK
dc.identifier.spage315en_HK
dc.identifier.epage322en_HK
dc.identifier.isiWOS:000252974700006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridMok, MY=7006024184en_HK
dc.identifier.scopusauthoridFung, PCW=7101613315en_HK
dc.identifier.scopusauthoridOoi, C=7007084909en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.scopusauthoridWong, Y=7403041884en_HK
dc.identifier.scopusauthoridLam, YM=35316083700en_HK
dc.identifier.scopusauthoridWong, WS=8737892100en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK

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