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Article: HLA associations, microsatellite instability and epigenetic changes in thyroid lymphoma in Chinese

TitleHLA associations, microsatellite instability and epigenetic changes in thyroid lymphoma in Chinese
Authors
Issue Date2007
PublisherInforma Healthcare. The Journal's web site is located at http://informahealthcare.com/loi/lal
Citation
Leukemia And Lymphoma, 2007, v. 48 n. 3, p. 531-534 How to Cite?
AbstractIn Chinese, autoimmune thyroid disease (AITD) is very common but lymphoma of the thyroid is a rare disease. Southern Chinese AITD is common in females and is strongly linked to the HLA haplotype A2B46DR9. We studied the HLA association, aberration p15, p16 and p73 promoter methylation and microsatellite instability in Chinese primary thyroid lymphoma patients to elucidate their relationship with AITD and the relationship between thyroid diffuse large cell lymphoma (DLCL) and marginal zone lymphomas (MZL). Despite a female preponderance (8:1) and the finding of cases with histological and immunological evidence of AITD, a significant HLA association was not found. MSI was absent, but aberrant promoter methylation was found in both thyroid MZL and DLCL and p73 methylation was unexpectedly common.
Persistent Identifierhttp://hdl.handle.net/10722/78530
ISSN
2015 Impact Factor: 3.093
2015 SCImago Journal Rankings: 1.202
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWy, Aen_HK
dc.contributor.authorFung, Aen_HK
dc.contributor.authorMa, ESen_HK
dc.contributor.authorShek, TWen_HK
dc.contributor.authorHawkins, BRen_HK
dc.contributor.authorLiang, Ren_HK
dc.date.accessioned2010-09-06T07:43:54Z-
dc.date.available2010-09-06T07:43:54Z-
dc.date.issued2007en_HK
dc.identifier.citationLeukemia And Lymphoma, 2007, v. 48 n. 3, p. 531-534en_HK
dc.identifier.issn1042-8194en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78530-
dc.description.abstractIn Chinese, autoimmune thyroid disease (AITD) is very common but lymphoma of the thyroid is a rare disease. Southern Chinese AITD is common in females and is strongly linked to the HLA haplotype A2B46DR9. We studied the HLA association, aberration p15, p16 and p73 promoter methylation and microsatellite instability in Chinese primary thyroid lymphoma patients to elucidate their relationship with AITD and the relationship between thyroid diffuse large cell lymphoma (DLCL) and marginal zone lymphomas (MZL). Despite a female preponderance (8:1) and the finding of cases with histological and immunological evidence of AITD, a significant HLA association was not found. MSI was absent, but aberrant promoter methylation was found in both thyroid MZL and DLCL and p73 methylation was unexpectedly common.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://informahealthcare.com/loi/lalen_HK
dc.relation.ispartofLeukemia and Lymphomaen_HK
dc.rightsLeukemia and Lymphoma. Copyright © Informa Healthcare.en_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAsian Continental Ancestry Groupen_HK
dc.subject.meshCarcinoma, Papillary - genetics - immunology - therapyen_HK
dc.subject.meshChina - epidemiologyen_HK
dc.subject.meshCyclin-Dependent Kinase Inhibitor p16 - geneticsen_HK
dc.subject.meshDNA Methylationen_HK
dc.subject.meshEpigenesis, Geneticen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Expression Regulation, Neoplasticen_HK
dc.subject.meshHLA Antigens - geneticsen_HK
dc.subject.meshHaplotypesen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLymphoma, B-Cell - genetics - immunology - therapyen_HK
dc.subject.meshLymphoma, Large B-Cell, Diffuse - genetics - immunology - therapyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMicrosatellite Instabilityen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPromoter Regions, Genetic - geneticsen_HK
dc.subject.meshThyroid Neoplasms - genetics - immunology - therapyen_HK
dc.subject.meshThyroiditis, Autoimmune - genetics - immunology - therapyen_HK
dc.titleHLA associations, microsatellite instability and epigenetic changes in thyroid lymphoma in Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1042-8194&volume=48&issue=3&spage=531&epage=534&date=2007&atitle=HLA+associations,+microsatellite+instability+and+epigenetic+changes+in+thyroid+lymphoma+in+Chineseen_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/10428190601149562en_HK
dc.identifier.pmid17454594-
dc.identifier.scopuseid_2-s2.0-33947692739en_HK
dc.identifier.hkuros136969en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33947692739&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume48en_HK
dc.identifier.issue3en_HK
dc.identifier.spage531en_HK
dc.identifier.epage534en_HK
dc.identifier.isiWOS:000245108100017-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWy, A=16069959800en_HK
dc.identifier.scopusauthoridFung, A=7101926728en_HK
dc.identifier.scopusauthoridMa, ES=7202039934en_HK
dc.identifier.scopusauthoridShek, TW=7005479861en_HK
dc.identifier.scopusauthoridHawkins, BR=35944486200en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK

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