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Article: Hepatitis B virus-related nephropathy and lupus nephritis: Morphologic similarities of two clinical entities

TitleHepatitis B virus-related nephropathy and lupus nephritis: Morphologic similarities of two clinical entities
Authors
KeywordsAntinuclear antibodies
Hematoxyphil bodies
Hepatitis B virus
Hepatitis B virus-related nephropathy
Lupus nephritis
Membranous nephropathy
Systemic lupus erythematosus
Issue Date2000
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/modpathol/
Citation
Modern Pathology, 2000, v. 13 n. 2, p. 166-172 How to Cite?
AbstractWe compared the clinicopathologic features of 22 patients with hepatitis B virus-related membranous nephropathy, all with detectable glomerular hepatitis B e antigen, and of 26 patients with lupus nephritis class V. Both groups of patients similarly presented with heavy proteinuria or nephrotic syndrome; however, the patients with hepatitis B virus-related membranous nephropathy, who were predominantly male, did not have the extrarenal manifestations and autoantibodies seen in systemic lupus erythematosus. The glomerular lesions in both clinical entities were similar and at times indistinguishable, demonstrating polyclonal immunoglobulins and polytypic complements in similar subepithelial ultrastructural distribution. No morphologic feature, single or combined, carrying a high positive predictive value for the diagnosis of either nephritis was identified. Lesions such as hematoxyphil bodies and fingerprint dense deposits, distinctive of systemic lupus erythematosus, were rarely found. At the time of biopsy, when systemic lupus erythematosus is not clinically suspected, the diagnosis between hepatitis B virus-related membranous nephropathy and lupus nephritis may be difficult or impossible to differentiate, especially in geographic areas where both lupus nephritis and hepatitis B surface antigen carriers are common. This study focused on the use of specific monoclonal antisera to detect glomerular hepatitis B virus antigens, which contribute to the diagnosis of hepatitis B virus-related nephritis.
Persistent Identifierhttp://hdl.handle.net/10722/78525
ISSN
2015 Impact Factor: 5.485
2015 SCImago Journal Rankings: 2.803
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFernand MacMoune, Len_HK
dc.contributor.authorTo, KFen_HK
dc.contributor.authorWang, AYMen_HK
dc.contributor.authorChoi, PCLen_HK
dc.contributor.authorSzeto, CCen_HK
dc.contributor.authorLi, PKTen_HK
dc.contributor.authorLeung, CBen_HK
dc.contributor.authorLai, KNen_HK
dc.date.accessioned2010-09-06T07:43:51Z-
dc.date.available2010-09-06T07:43:51Z-
dc.date.issued2000en_HK
dc.identifier.citationModern Pathology, 2000, v. 13 n. 2, p. 166-172en_HK
dc.identifier.issn0893-3952en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78525-
dc.description.abstractWe compared the clinicopathologic features of 22 patients with hepatitis B virus-related membranous nephropathy, all with detectable glomerular hepatitis B e antigen, and of 26 patients with lupus nephritis class V. Both groups of patients similarly presented with heavy proteinuria or nephrotic syndrome; however, the patients with hepatitis B virus-related membranous nephropathy, who were predominantly male, did not have the extrarenal manifestations and autoantibodies seen in systemic lupus erythematosus. The glomerular lesions in both clinical entities were similar and at times indistinguishable, demonstrating polyclonal immunoglobulins and polytypic complements in similar subepithelial ultrastructural distribution. No morphologic feature, single or combined, carrying a high positive predictive value for the diagnosis of either nephritis was identified. Lesions such as hematoxyphil bodies and fingerprint dense deposits, distinctive of systemic lupus erythematosus, were rarely found. At the time of biopsy, when systemic lupus erythematosus is not clinically suspected, the diagnosis between hepatitis B virus-related membranous nephropathy and lupus nephritis may be difficult or impossible to differentiate, especially in geographic areas where both lupus nephritis and hepatitis B surface antigen carriers are common. This study focused on the use of specific monoclonal antisera to detect glomerular hepatitis B virus antigens, which contribute to the diagnosis of hepatitis B virus-related nephritis.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/modpathol/en_HK
dc.relation.ispartofModern Pathologyen_HK
dc.subjectAntinuclear antibodiesen_HK
dc.subjectHematoxyphil bodiesen_HK
dc.subjectHepatitis B virusen_HK
dc.subjectHepatitis B virus-related nephropathyen_HK
dc.subjectLupus nephritisen_HK
dc.subjectMembranous nephropathyen_HK
dc.subjectSystemic lupus erythematosusen_HK
dc.titleHepatitis B virus-related nephropathy and lupus nephritis: Morphologic similarities of two clinical entitiesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0893-3952&volume=13&issue=2&spage=166&epage=172&date=2000&atitle=Hepatitis+B+virus-related+nephropathy+and+lupus+nephritis:+morphologic+similarities+of+two+clinical+entitiesen_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10697274-
dc.identifier.scopuseid_2-s2.0-0343048350en_HK
dc.identifier.hkuros50618en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0343048350&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue2en_HK
dc.identifier.spage166en_HK
dc.identifier.epage172en_HK
dc.identifier.isiWOS:000085423200010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridFernand MacMoune, L=6508338172en_HK
dc.identifier.scopusauthoridTo, KF=7101911940en_HK
dc.identifier.scopusauthoridWang, AYM=13606226000en_HK
dc.identifier.scopusauthoridChoi, PCL=7102909169en_HK
dc.identifier.scopusauthoridSzeto, CC=35495407200en_HK
dc.identifier.scopusauthoridLi, PKT=25928016800en_HK
dc.identifier.scopusauthoridLeung, CB=16750769500en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK

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