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Article: Reversal of left ventricular remodeling by synchronous biventricular pacing in heart failure

TitleReversal of left ventricular remodeling by synchronous biventricular pacing in heart failure
Authors
Issue Date2000
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0147-8389&site=1
Citation
Pace - Pacing And Clinical Electrophysiology, 2000, v. 23 n. 11 II, p. 1722-1725 How to Cite?
AbstractSynchronous biventricular pacing is a new nonpharmacological supplemental treatment of advanced heart failure associated with electromechanical conduction delay. However, the role of pacing on left ventricular remodeling is unknown. Eleven patients with New York Heart Association Class III to IV heart failure, a left ventricular ejection fraction < 35%, and a QRS duration ≥ 140 ms received a biventricular dual chamber pacemaker. Serial echocardiography, 6-minute hall walk, and Minnesota Living with Heart Failure quality-of-life (QOL) questionnaire were performed before and after, up to 3 months of pacing. At 3 months there was a significant increase in fractional shortening (P < 0.001), ejection fraction (P < 0.001), and cardiac output (P < 0.05). The left ventricular end-diastolic volume (245 ± 70 vs 185 ± 37 mL, P < 0.05), end-systolic volume (209 ± 69 vs 140 ± 44 mL P < 0.05), and mitral regurgitation were reduced (P < 0.05), and diastolic filling time was lengthened (P < 0.05). There were also improvements in heart failure symptoms, an increase in 6-minute walk distance, and a decrease in QOL scores. Synchronous biventricular pacing for 3 months was associated with hemodynamic improvements, reversal of left ventricular remodeling, and increase in left ventricular systolic function, and a decrease in secondary mitral regurgitation.
Persistent Identifierhttp://hdl.handle.net/10722/78506
ISSN
2015 Impact Factor: 1.156
2015 SCImago Journal Rankings: 0.662
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLau, CPen_HK
dc.contributor.authorYu, CMen_HK
dc.contributor.authorChau, Een_HK
dc.contributor.authorFan, Ken_HK
dc.contributor.authorTse, HFen_HK
dc.contributor.authorLee, Ken_HK
dc.contributor.authorTang, MOen_HK
dc.contributor.authorWan, SHen_HK
dc.contributor.authorLaw, TCen_HK
dc.contributor.authorLee, PYen_HK
dc.contributor.authorLam, YMen_HK
dc.contributor.authorHill, MRSen_HK
dc.date.accessioned2010-09-06T07:43:38Z-
dc.date.available2010-09-06T07:43:38Z-
dc.date.issued2000en_HK
dc.identifier.citationPace - Pacing And Clinical Electrophysiology, 2000, v. 23 n. 11 II, p. 1722-1725en_HK
dc.identifier.issn0147-8389en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78506-
dc.description.abstractSynchronous biventricular pacing is a new nonpharmacological supplemental treatment of advanced heart failure associated with electromechanical conduction delay. However, the role of pacing on left ventricular remodeling is unknown. Eleven patients with New York Heart Association Class III to IV heart failure, a left ventricular ejection fraction < 35%, and a QRS duration ≥ 140 ms received a biventricular dual chamber pacemaker. Serial echocardiography, 6-minute hall walk, and Minnesota Living with Heart Failure quality-of-life (QOL) questionnaire were performed before and after, up to 3 months of pacing. At 3 months there was a significant increase in fractional shortening (P < 0.001), ejection fraction (P < 0.001), and cardiac output (P < 0.05). The left ventricular end-diastolic volume (245 ± 70 vs 185 ± 37 mL, P < 0.05), end-systolic volume (209 ± 69 vs 140 ± 44 mL P < 0.05), and mitral regurgitation were reduced (P < 0.05), and diastolic filling time was lengthened (P < 0.05). There were also improvements in heart failure symptoms, an increase in 6-minute walk distance, and a decrease in QOL scores. Synchronous biventricular pacing for 3 months was associated with hemodynamic improvements, reversal of left ventricular remodeling, and increase in left ventricular systolic function, and a decrease in secondary mitral regurgitation.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0147-8389&site=1en_HK
dc.relation.ispartofPACE - Pacing and Clinical Electrophysiologyen_HK
dc.subject.meshCardiac Pacing, Artificial - methodsen_HK
dc.subject.meshCardiac Volumeen_HK
dc.subject.meshEchocardiographyen_HK
dc.subject.meshExercise Testen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHeart Failure - complications - surgeryen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMitral Valve Insufficiency - complications - therapyen_HK
dc.subject.meshPacemaker, Artificialen_HK
dc.subject.meshQuality of Lifeen_HK
dc.subject.meshRemission Inductionen_HK
dc.subject.meshStroke Volumeen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.subject.meshVentricular Dysfunction, Left - complications - therapyen_HK
dc.subject.meshVentricular Dysfunction, Right - complications - therapyen_HK
dc.subject.meshVentricular Remodelingen_HK
dc.titleReversal of left ventricular remodeling by synchronous biventricular pacing in heart failureen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0147-8389&volume=23&issue=11&spage=1722&epage=1725&date=2000&atitle=Reversal+of+left+ventricular+remodeling+by+synchronous+biventricular+pacing+in+heart+failureen_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11139909-
dc.identifier.scopuseid_2-s2.0-0033665997en_HK
dc.identifier.hkuros115131en_HK
dc.identifier.hkuros56330-
dc.identifier.hkuros100904-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033665997&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue11 IIen_HK
dc.identifier.spage1722en_HK
dc.identifier.epage1725en_HK
dc.identifier.isiWOS:000165755900004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.scopusauthoridYu, CM=7404976646en_HK
dc.identifier.scopusauthoridChau, E=8081027500en_HK
dc.identifier.scopusauthoridFan, K=7202978353en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.scopusauthoridLee, K=7501505962en_HK
dc.identifier.scopusauthoridTang, MO=7401973887en_HK
dc.identifier.scopusauthoridWan, SH=7202724280en_HK
dc.identifier.scopusauthoridLaw, TC=35818198700en_HK
dc.identifier.scopusauthoridLee, PY=8933949600en_HK
dc.identifier.scopusauthoridLam, YM=35316083700en_HK
dc.identifier.scopusauthoridHill, MRS=7404447705en_HK

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