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Article: Impaired nitrate-mediated dilatation could reflect nitrate tolerance in patients with coronary artery disease
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TitleImpaired nitrate-mediated dilatation could reflect nitrate tolerance in patients with coronary artery disease
 
AuthorsHu, R1 2
Siu, CW1
Lau, EO1
Wang, WQ2
Lau, CP1
Tse, HF1
 
Issue Date2007
 
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
 
CitationInternational Journal Of Cardiology, 2007, v. 120 n. 3, p. 351-356 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ijcard.2006.10.011
 
AbstractAim: To investigate whether nitrate-mediated dilatation (NMD) of the brachial artery could be impaired by the use of nitrates and reflect nitrate tolerance in coronary artery disease (CAD) patients. Methods: A total of 243 patients (mean age 61 ± 12 years, 146 male) were recruited before coronary angiography. Gensini score was calculated to assess the severity of CAD. Flow-mediated dilatation (FMD) and NMD of the brachial artery were measured. Results: NMD progressively decreased from subjects without CAD (control group, n = 71) to non-nitrate users (n = 64) and nitrate users (n = 108) with CAD (16.2 ± 6.01% versus 13.4 ± 5.57% versus 9.57 ± 4.52%, P < 0.001 for all). Multiple linear regression analysis showed that age, FMD, diameter of the brachial artery, hypertension, and nitrate use were independent determinants of NMD. In subgroup analysis of patients with high Gensini score (> 10), nitrate users (n = 56, 9.00 ± 4.00%) had a significant lower NMD than non-users (n = 28, 12.4 ± 5.45%, P < 0.001), but no difference in other parameters including age, prevalence of hypertension, FMD, Gensini score and use of other medications. Conclusions: The use of nitrates independently impaired NMD in CAD patients. An impaired NMD could be a comprehensive index of nitrate tolerance in patients with CAD. © 2006 Elsevier Ireland Ltd. All rights reserved.
 
ISSN0167-5273
2013 Impact Factor: 6.175
2013 SCImago Journal Rankings: 0.930
 
DOIhttp://dx.doi.org/10.1016/j.ijcard.2006.10.011
 
ISI Accession Number IDWOS:000251062200011
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHu, R
 
dc.contributor.authorSiu, CW
 
dc.contributor.authorLau, EO
 
dc.contributor.authorWang, WQ
 
dc.contributor.authorLau, CP
 
dc.contributor.authorTse, HF
 
dc.date.accessioned2010-09-06T07:43:36Z
 
dc.date.available2010-09-06T07:43:36Z
 
dc.date.issued2007
 
dc.description.abstractAim: To investigate whether nitrate-mediated dilatation (NMD) of the brachial artery could be impaired by the use of nitrates and reflect nitrate tolerance in coronary artery disease (CAD) patients. Methods: A total of 243 patients (mean age 61 ± 12 years, 146 male) were recruited before coronary angiography. Gensini score was calculated to assess the severity of CAD. Flow-mediated dilatation (FMD) and NMD of the brachial artery were measured. Results: NMD progressively decreased from subjects without CAD (control group, n = 71) to non-nitrate users (n = 64) and nitrate users (n = 108) with CAD (16.2 ± 6.01% versus 13.4 ± 5.57% versus 9.57 ± 4.52%, P < 0.001 for all). Multiple linear regression analysis showed that age, FMD, diameter of the brachial artery, hypertension, and nitrate use were independent determinants of NMD. In subgroup analysis of patients with high Gensini score (> 10), nitrate users (n = 56, 9.00 ± 4.00%) had a significant lower NMD than non-users (n = 28, 12.4 ± 5.45%, P < 0.001), but no difference in other parameters including age, prevalence of hypertension, FMD, Gensini score and use of other medications. Conclusions: The use of nitrates independently impaired NMD in CAD patients. An impaired NMD could be a comprehensive index of nitrate tolerance in patients with CAD. © 2006 Elsevier Ireland Ltd. All rights reserved.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationInternational Journal Of Cardiology, 2007, v. 120 n. 3, p. 351-356 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ijcard.2006.10.011
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.ijcard.2006.10.011
 
dc.identifier.epage356
 
dc.identifier.hkuros126562
 
dc.identifier.isiWOS:000251062200011
 
dc.identifier.issn0167-5273
2013 Impact Factor: 6.175
2013 SCImago Journal Rankings: 0.930
 
dc.identifier.issue3
 
dc.identifier.openurl
 
dc.identifier.pmid17174421
 
dc.identifier.scopuseid_2-s2.0-34447530275
 
dc.identifier.spage351
 
dc.identifier.urihttp://hdl.handle.net/10722/78503
 
dc.identifier.volume120
 
dc.languageeng
 
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
 
dc.publisher.placeIreland
 
dc.relation.ispartofInternational Journal of Cardiology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsInternational Journal of Cardiology. Copyright © Elsevier Ireland Ltd.
 
dc.subject.meshAdult
 
dc.subject.meshAge Factors
 
dc.subject.meshAged
 
dc.subject.meshAged, 80 and over
 
dc.subject.meshBrachial Artery - physiopathology - ultrasonography
 
dc.subject.meshCase-Control Studies
 
dc.subject.meshCoronary Angiography
 
dc.subject.meshCoronary Artery Disease - physiopathology - radiography
 
dc.subject.meshDrug Tolerance - physiology
 
dc.subject.meshEndothelium, Vascular - physiopathology - ultrasonography
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshHypertension - physiopathology
 
dc.subject.meshLinear Models
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshNitroglycerin - pharmacology
 
dc.subject.meshRegional Blood Flow - physiology
 
dc.subject.meshVasodilation - drug effects - physiology
 
dc.subject.meshVasodilator Agents - pharmacology
 
dc.titleImpaired nitrate-mediated dilatation could reflect nitrate tolerance in patients with coronary artery disease
 
dc.typeArticle
 
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<contributor.author>Siu, CW</contributor.author>
<contributor.author>Lau, EO</contributor.author>
<contributor.author>Wang, WQ</contributor.author>
<contributor.author>Lau, CP</contributor.author>
<contributor.author>Tse, HF</contributor.author>
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<description.abstract>Aim: To investigate whether nitrate-mediated dilatation (NMD) of the brachial artery could be impaired by the use of nitrates and reflect nitrate tolerance in coronary artery disease (CAD) patients. Methods: A total of 243 patients (mean age 61 &#177; 12&#160;years, 146 male) were recruited before coronary angiography. Gensini score was calculated to assess the severity of CAD. Flow-mediated dilatation (FMD) and NMD of the brachial artery were measured. Results: NMD progressively decreased from subjects without CAD (control group, n = 71) to non-nitrate users (n = 64) and nitrate users (n = 108) with CAD (16.2 &#177; 6.01% versus 13.4 &#177; 5.57% versus 9.57 &#177; 4.52%, P &lt; 0.001 for all). Multiple linear regression analysis showed that age, FMD, diameter of the brachial artery, hypertension, and nitrate use were independent determinants of NMD. In subgroup analysis of patients with high Gensini score (&gt; 10), nitrate users (n = 56, 9.00 &#177; 4.00%) had a significant lower NMD than non-users (n = 28, 12.4 &#177; 5.45%, P &lt; 0.001), but no difference in other parameters including age, prevalence of hypertension, FMD, Gensini score and use of other medications. Conclusions: The use of nitrates independently impaired NMD in CAD patients. An impaired NMD could be a comprehensive index of nitrate tolerance in patients with CAD. &#169; 2006 Elsevier Ireland Ltd. All rights reserved.</description.abstract>
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<subject.mesh>Adult</subject.mesh>
<subject.mesh>Age Factors</subject.mesh>
<subject.mesh>Aged</subject.mesh>
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<subject.mesh>Middle Aged</subject.mesh>
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<subject.mesh>Vasodilation - drug effects - physiology</subject.mesh>
<subject.mesh>Vasodilator Agents - pharmacology</subject.mesh>
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Author Affiliations
  1. The University of Hong Kong
  2. Jinshan Hospital