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Article: Impaired nitrate-mediated dilatation could reflect nitrate tolerance in patients with coronary artery disease

TitleImpaired nitrate-mediated dilatation could reflect nitrate tolerance in patients with coronary artery disease
Authors
Issue Date2007
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
Citation
International Journal Of Cardiology, 2007, v. 120 n. 3, p. 351-356 How to Cite?
AbstractAim: To investigate whether nitrate-mediated dilatation (NMD) of the brachial artery could be impaired by the use of nitrates and reflect nitrate tolerance in coronary artery disease (CAD) patients. Methods: A total of 243 patients (mean age 61 ± 12 years, 146 male) were recruited before coronary angiography. Gensini score was calculated to assess the severity of CAD. Flow-mediated dilatation (FMD) and NMD of the brachial artery were measured. Results: NMD progressively decreased from subjects without CAD (control group, n = 71) to non-nitrate users (n = 64) and nitrate users (n = 108) with CAD (16.2 ± 6.01% versus 13.4 ± 5.57% versus 9.57 ± 4.52%, P < 0.001 for all). Multiple linear regression analysis showed that age, FMD, diameter of the brachial artery, hypertension, and nitrate use were independent determinants of NMD. In subgroup analysis of patients with high Gensini score (> 10), nitrate users (n = 56, 9.00 ± 4.00%) had a significant lower NMD than non-users (n = 28, 12.4 ± 5.45%, P < 0.001), but no difference in other parameters including age, prevalence of hypertension, FMD, Gensini score and use of other medications. Conclusions: The use of nitrates independently impaired NMD in CAD patients. An impaired NMD could be a comprehensive index of nitrate tolerance in patients with CAD. © 2006 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/78503
ISSN
2015 Impact Factor: 4.638
2015 SCImago Journal Rankings: 1.513
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHu, Ren_HK
dc.contributor.authorSiu, CWen_HK
dc.contributor.authorLau, EOen_HK
dc.contributor.authorWang, WQen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2010-09-06T07:43:36Z-
dc.date.available2010-09-06T07:43:36Z-
dc.date.issued2007en_HK
dc.identifier.citationInternational Journal Of Cardiology, 2007, v. 120 n. 3, p. 351-356en_HK
dc.identifier.issn0167-5273en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78503-
dc.description.abstractAim: To investigate whether nitrate-mediated dilatation (NMD) of the brachial artery could be impaired by the use of nitrates and reflect nitrate tolerance in coronary artery disease (CAD) patients. Methods: A total of 243 patients (mean age 61 ± 12 years, 146 male) were recruited before coronary angiography. Gensini score was calculated to assess the severity of CAD. Flow-mediated dilatation (FMD) and NMD of the brachial artery were measured. Results: NMD progressively decreased from subjects without CAD (control group, n = 71) to non-nitrate users (n = 64) and nitrate users (n = 108) with CAD (16.2 ± 6.01% versus 13.4 ± 5.57% versus 9.57 ± 4.52%, P < 0.001 for all). Multiple linear regression analysis showed that age, FMD, diameter of the brachial artery, hypertension, and nitrate use were independent determinants of NMD. In subgroup analysis of patients with high Gensini score (> 10), nitrate users (n = 56, 9.00 ± 4.00%) had a significant lower NMD than non-users (n = 28, 12.4 ± 5.45%, P < 0.001), but no difference in other parameters including age, prevalence of hypertension, FMD, Gensini score and use of other medications. Conclusions: The use of nitrates independently impaired NMD in CAD patients. An impaired NMD could be a comprehensive index of nitrate tolerance in patients with CAD. © 2006 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcarden_HK
dc.relation.ispartofInternational Journal of Cardiologyen_HK
dc.rightsInternational Journal of Cardiology. Copyright © Elsevier Ireland Ltd.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAge Factorsen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshBrachial Artery - physiopathology - ultrasonographyen_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshCoronary Angiographyen_HK
dc.subject.meshCoronary Artery Disease - physiopathology - radiographyen_HK
dc.subject.meshDrug Tolerance - physiologyen_HK
dc.subject.meshEndothelium, Vascular - physiopathology - ultrasonographyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypertension - physiopathologyen_HK
dc.subject.meshLinear Modelsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNitroglycerin - pharmacologyen_HK
dc.subject.meshRegional Blood Flow - physiologyen_HK
dc.subject.meshVasodilation - drug effects - physiologyen_HK
dc.subject.meshVasodilator Agents - pharmacologyen_HK
dc.titleImpaired nitrate-mediated dilatation could reflect nitrate tolerance in patients with coronary artery diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0167-5273&volume=120&issue=3&spage=351&epage=6&date=2006&atitle=Impaired+nitrate-mediated+dilatation+could+reflect+nitrate+tolerance+in+patients+with+coronary+artery+diseaseen_HK
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authoritySiu, CW=rp00534en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijcard.2006.10.011en_HK
dc.identifier.pmid17174421-
dc.identifier.scopuseid_2-s2.0-34447530275en_HK
dc.identifier.hkuros126562en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34447530275&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume120en_HK
dc.identifier.issue3en_HK
dc.identifier.spage351en_HK
dc.identifier.epage356en_HK
dc.identifier.isiWOS:000251062200011-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridHu, R=55163131900en_HK
dc.identifier.scopusauthoridSiu, CW=7006550690en_HK
dc.identifier.scopusauthoridLau, EO=12800522700en_HK
dc.identifier.scopusauthoridWang, WQ=7501758106en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK

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