Article: Impaired nitrate-mediated dilatation could reflect nitrate tolerance in patients with coronary artery disease

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TitleImpaired nitrate-mediated dilatation could reflect nitrate tolerance in patients with coronary artery disease
AuthorsHu, R1 2
Siu, CW1
Lau, EO1
Wang, WQ2
Lau, CP1
Tse, HF1
Issue Date2007
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
CitationInternational Journal Of Cardiology, 2007, v. 120 n. 3, p. 351-356 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ijcard.2006.10.011
AbstractAim: To investigate whether nitrate-mediated dilatation (NMD) of the brachial artery could be impaired by the use of nitrates and reflect nitrate tolerance in coronary artery disease (CAD) patients. Methods: A total of 243 patients (mean age 61 ± 12 years, 146 male) were recruited before coronary angiography. Gensini score was calculated to assess the severity of CAD. Flow-mediated dilatation (FMD) and NMD of the brachial artery were measured. Results: NMD progressively decreased from subjects without CAD (control group, n = 71) to non-nitrate users (n = 64) and nitrate users (n = 108) with CAD (16.2 ± 6.01% versus 13.4 ± 5.57% versus 9.57 ± 4.52%, P < 0.001 for all). Multiple linear regression analysis showed that age, FMD, diameter of the brachial artery, hypertension, and nitrate use were independent determinants of NMD. In subgroup analysis of patients with high Gensini score (> 10), nitrate users (n = 56, 9.00 ± 4.00%) had a significant lower NMD than non-users (n = 28, 12.4 ± 5.45%, P < 0.001), but no difference in other parameters including age, prevalence of hypertension, FMD, Gensini score and use of other medications. Conclusions: The use of nitrates independently impaired NMD in CAD patients. An impaired NMD could be a comprehensive index of nitrate tolerance in patients with CAD. © 2006 Elsevier Ireland Ltd. All rights reserved.
ISSN0167-5273
2011 Impact Factor: 7.078
2011 SCImago Journal Rankings: 0.144
DOIhttp://dx.doi.org/10.1016/j.ijcard.2006.10.011
ISI Accession Number IDWOS:000251062200011
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorHu, R
dc.contributor.authorSiu, CW
dc.contributor.authorLau, EO
dc.contributor.authorWang, WQ
dc.contributor.authorLau, CP
dc.contributor.authorTse, HF
dc.date.accessioned2010-09-06T07:43:36Z
dc.date.available2010-09-06T07:43:36Z
dc.date.issued2007
dc.description.abstractAim: To investigate whether nitrate-mediated dilatation (NMD) of the brachial artery could be impaired by the use of nitrates and reflect nitrate tolerance in coronary artery disease (CAD) patients. Methods: A total of 243 patients (mean age 61 ± 12 years, 146 male) were recruited before coronary angiography. Gensini score was calculated to assess the severity of CAD. Flow-mediated dilatation (FMD) and NMD of the brachial artery were measured. Results: NMD progressively decreased from subjects without CAD (control group, n = 71) to non-nitrate users (n = 64) and nitrate users (n = 108) with CAD (16.2 ± 6.01% versus 13.4 ± 5.57% versus 9.57 ± 4.52%, P < 0.001 for all). Multiple linear regression analysis showed that age, FMD, diameter of the brachial artery, hypertension, and nitrate use were independent determinants of NMD. In subgroup analysis of patients with high Gensini score (> 10), nitrate users (n = 56, 9.00 ± 4.00%) had a significant lower NMD than non-users (n = 28, 12.4 ± 5.45%, P < 0.001), but no difference in other parameters including age, prevalence of hypertension, FMD, Gensini score and use of other medications. Conclusions: The use of nitrates independently impaired NMD in CAD patients. An impaired NMD could be a comprehensive index of nitrate tolerance in patients with CAD. © 2006 Elsevier Ireland Ltd. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationInternational Journal Of Cardiology, 2007, v. 120 n. 3, p. 351-356 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ijcard.2006.10.011
dc.identifier.doihttp://dx.doi.org/10.1016/j.ijcard.2006.10.011
dc.identifier.epage356
dc.identifier.hkuros126562
dc.identifier.isiWOS:000251062200011
dc.identifier.issn0167-5273
2011 Impact Factor: 7.078
2011 SCImago Journal Rankings: 0.144
dc.identifier.issue3
dc.identifier.openurl
dc.identifier.pmid17174421
dc.identifier.scopuseid_2-s2.0-34447530275
dc.identifier.spage351
dc.identifier.urihttp://hdl.handle.net/10722/78503
dc.identifier.volume120
dc.languageeng
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
dc.publisher.placeIreland
dc.relation.ispartofInternational Journal of Cardiology
dc.relation.referencesReferences in Scopus
dc.rightsInternational Journal of Cardiology. Copyright © Elsevier Ireland Ltd.
dc.subject.meshAdult
dc.subject.meshAge Factors
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshBrachial Artery - physiopathology - ultrasonography
dc.subject.meshCase-Control Studies
dc.subject.meshCoronary Angiography
dc.subject.meshCoronary Artery Disease - physiopathology - radiography
dc.subject.meshDrug Tolerance - physiology
dc.subject.meshEndothelium, Vascular - physiopathology - ultrasonography
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshHypertension - physiopathology
dc.subject.meshLinear Models
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNitroglycerin - pharmacology
dc.subject.meshRegional Blood Flow - physiology
dc.subject.meshVasodilation - drug effects - physiology
dc.subject.meshVasodilator Agents - pharmacology
dc.titleImpaired nitrate-mediated dilatation could reflect nitrate tolerance in patients with coronary artery disease
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Jinshan Hospital