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Article: Estrogen receptor α CA dinucleotide repeat polymorphism is associated with rate of bone loss in perimenopausal women and bone mineral density and risk of osteoporotic fractures in postmenopausal women

TitleEstrogen receptor α CA dinucleotide repeat polymorphism is associated with rate of bone loss in perimenopausal women and bone mineral density and risk of osteoporotic fractures in postmenopausal women
Authors
KeywordsAssociation
BMD
Estrogen receptor alpha
Fracture
Osteoporosis
Polymorphism
Issue Date2008
PublisherSpringer U K. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/198
Citation
Osteoporosis International, 2008, v. 19 n. 4, p. 571-579 How to Cite?
AbstractThe association between a newly identified CA repeat polymorphism of the estrogen receptor alpha gene (ESR1) with osteoporosis was investigated. Postmenopausal women with <18 CA repeats had low BMD, increased rate of bone loss and increased fracture risk. Introduction: Studies have shown that intronic dinucleotide repeat polymorphisms in some genes are associated with disease risk by modulating mRNA splicing efficiency. D6S440 is a newly identified intronic CA repeat polymorphism located downstream of the 5′-splicing site of exon 5 of ESR1. Methods: The associations of D6S440 with bone mineral density (BMD), rate of bone loss and fracture risk were evaluated in 452 pre-, 110 peri- and 622 postmenopausal southern Chinese women using regression models. Results: Post- but not premenopausal women with less CA repeats had lower spine and hip BMD. The number of CA repeats was linearly related to hip BMD in postmenopausal women (β=0.008; p=0.004). Postmenopausal women with CA repeats <18 had higher risks of having osteoporosis (BMD T-score<-2.5 at the spine: OR 2.46, 95% CI 1.30-4.65; at the hip: OR 3.79(1.64-8.74)) and low trauma fractures (OR 2.31(1.29-4.14)) than those with ≥18 repeats. Perimenopausal women with <18 CA repeats had significantly greater bone loss in 18 months at the hip than those with ≥18 repeats (-1.96% vs. -1.61%, p=0.029). Conclusions: ESR1 CA repeat polymorphism is associated with BMD variation, rate of bone loss and fracture risk, and this may be a useful genetic marker for fracture risk assessment. © International Osteoporosis Foundation and National Osteoporosis Foundation 2007.
Persistent Identifierhttp://hdl.handle.net/10722/78502
ISSN
2015 Impact Factor: 3.445
2015 SCImago Journal Rankings: 1.460
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLai, BMHen_HK
dc.contributor.authorCheung, CLen_HK
dc.contributor.authorLuk, KDKen_HK
dc.contributor.authorKung, AWCen_HK
dc.date.accessioned2010-09-06T07:43:36Z-
dc.date.available2010-09-06T07:43:36Z-
dc.date.issued2008en_HK
dc.identifier.citationOsteoporosis International, 2008, v. 19 n. 4, p. 571-579en_HK
dc.identifier.issn0937-941Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/78502-
dc.description.abstractThe association between a newly identified CA repeat polymorphism of the estrogen receptor alpha gene (ESR1) with osteoporosis was investigated. Postmenopausal women with <18 CA repeats had low BMD, increased rate of bone loss and increased fracture risk. Introduction: Studies have shown that intronic dinucleotide repeat polymorphisms in some genes are associated with disease risk by modulating mRNA splicing efficiency. D6S440 is a newly identified intronic CA repeat polymorphism located downstream of the 5′-splicing site of exon 5 of ESR1. Methods: The associations of D6S440 with bone mineral density (BMD), rate of bone loss and fracture risk were evaluated in 452 pre-, 110 peri- and 622 postmenopausal southern Chinese women using regression models. Results: Post- but not premenopausal women with less CA repeats had lower spine and hip BMD. The number of CA repeats was linearly related to hip BMD in postmenopausal women (β=0.008; p=0.004). Postmenopausal women with CA repeats <18 had higher risks of having osteoporosis (BMD T-score<-2.5 at the spine: OR 2.46, 95% CI 1.30-4.65; at the hip: OR 3.79(1.64-8.74)) and low trauma fractures (OR 2.31(1.29-4.14)) than those with ≥18 repeats. Perimenopausal women with <18 CA repeats had significantly greater bone loss in 18 months at the hip than those with ≥18 repeats (-1.96% vs. -1.61%, p=0.029). Conclusions: ESR1 CA repeat polymorphism is associated with BMD variation, rate of bone loss and fracture risk, and this may be a useful genetic marker for fracture risk assessment. © International Osteoporosis Foundation and National Osteoporosis Foundation 2007.en_HK
dc.languageengen_HK
dc.publisherSpringer U K. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/198en_HK
dc.relation.ispartofOsteoporosis Internationalen_HK
dc.subjectAssociationen_HK
dc.subjectBMDen_HK
dc.subjectEstrogen receptor alphaen_HK
dc.subjectFractureen_HK
dc.subjectOsteoporosisen_HK
dc.subjectPolymorphismen_HK
dc.titleEstrogen receptor α CA dinucleotide repeat polymorphism is associated with rate of bone loss in perimenopausal women and bone mineral density and risk of osteoporotic fractures in postmenopausal womenen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0937-941X&volume=19&spage=571&epage=9&date=2007&atitle=Estrogen+receptor+α+CA+dinucleotide+repeat+polymorphism+is+associated+with+rate+of+bone+loss+in+perimenopausal+women+and+bone+mineral+density+and+risk+of+osteoporotic+fractures+in+postmenopausal+womenen_HK
dc.identifier.emailLuk, KDK:hcm21000@hku.hken_HK
dc.identifier.emailKung, AWC:awckung@hku.hken_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00198-007-0482-1en_HK
dc.identifier.scopuseid_2-s2.0-47249126240en_HK
dc.identifier.hkuros142082en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-47249126240&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue4en_HK
dc.identifier.spage571en_HK
dc.identifier.epage579en_HK
dc.identifier.isiWOS:000253995100018-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLai, BMH=24468678100en_HK
dc.identifier.scopusauthoridCheung, CL=34975244700en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK
dc.identifier.citeulike2752592-

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