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Article: Impact of untreated psychosis on quality of life in patients with first-episode schizophrenia

TitleImpact of untreated psychosis on quality of life in patients with first-episode schizophrenia
Authors
KeywordsFirst-episode schizophrenia
Period of untreated psychosis
Quality of life
Issue Date2005
PublisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0962-9343
Citation
Quality Of Life Research, 2005, v. 14 n. 8, p. 1803-1811 How to Cite?
AbstractDespite increasing interest in the quality of life (QOL) of psychiatric patients in recent years, few studies have focused on the potential adverse effects of the illness on QOL during the period of untreated psychosis. Our study compares the QOL of patients with first-episode schizophrenia when they first presented to the psychiatric service with that of the normal population, and identifies possible relationships with various clinical parameters. One hundred and seventeen patients with schizophrenia (aged 14-28 years) who entered the Early Assessment Services for Young People with Psychosis (EASY) programme in Hong Kong from June 2001 to January 2004 were assessed with the MOS 36 item Short Form Health Survey (SF-36) and the World Health Organization Quality of Life Measure, abbreviated Hong Kong version (WHOQOL-BREF(HK)). We compared their SF-36 scores with controls from the normal population matched by age, sex, marital status and educational level. We assessed clinical parameters including positive, negative and depressive symptoms by the Positive and Negative Syndrome Scale (PANSS), the Scale for Assessment of Negative Symptoms (SANS), and the Montgomery and Asberg Depression Rating Scale (MADRS). When compared with matched controls from the normal population, significantly lower scores in all of the eight scales of the SF-36 were found in our patient group (p < 0.005). Various QOL domain scores had significant inverse correlations with the total MADRS score. However, there was no significant correlation with other clinical parameters. Young patients with first-episode schizophrenia have poorer QOL in the period of untreated psychosis than their counterparts in the community. Amongst various clinical parameters, the severity of depressive symptoms correlates most with QOL. © Springer 2005.
Persistent Identifierhttp://hdl.handle.net/10722/78492
ISSN
2015 Impact Factor: 2.429
2015 SCImago Journal Rankings: 1.158
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLaw, CWen_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorCheung, EFCen_HK
dc.contributor.authorChan, RCKen_HK
dc.contributor.authorWong, JGWSen_HK
dc.contributor.authorLam, CLKen_HK
dc.contributor.authorLeung, KFen_HK
dc.contributor.authorLo, MSMen_HK
dc.date.accessioned2010-09-06T07:43:29Z-
dc.date.available2010-09-06T07:43:29Z-
dc.date.issued2005en_HK
dc.identifier.citationQuality Of Life Research, 2005, v. 14 n. 8, p. 1803-1811en_HK
dc.identifier.issn0962-9343en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78492-
dc.description.abstractDespite increasing interest in the quality of life (QOL) of psychiatric patients in recent years, few studies have focused on the potential adverse effects of the illness on QOL during the period of untreated psychosis. Our study compares the QOL of patients with first-episode schizophrenia when they first presented to the psychiatric service with that of the normal population, and identifies possible relationships with various clinical parameters. One hundred and seventeen patients with schizophrenia (aged 14-28 years) who entered the Early Assessment Services for Young People with Psychosis (EASY) programme in Hong Kong from June 2001 to January 2004 were assessed with the MOS 36 item Short Form Health Survey (SF-36) and the World Health Organization Quality of Life Measure, abbreviated Hong Kong version (WHOQOL-BREF(HK)). We compared their SF-36 scores with controls from the normal population matched by age, sex, marital status and educational level. We assessed clinical parameters including positive, negative and depressive symptoms by the Positive and Negative Syndrome Scale (PANSS), the Scale for Assessment of Negative Symptoms (SANS), and the Montgomery and Asberg Depression Rating Scale (MADRS). When compared with matched controls from the normal population, significantly lower scores in all of the eight scales of the SF-36 were found in our patient group (p < 0.005). Various QOL domain scores had significant inverse correlations with the total MADRS score. However, there was no significant correlation with other clinical parameters. Young patients with first-episode schizophrenia have poorer QOL in the period of untreated psychosis than their counterparts in the community. Amongst various clinical parameters, the severity of depressive symptoms correlates most with QOL. © Springer 2005.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0962-9343en_HK
dc.relation.ispartofQuality of Life Researchen_HK
dc.subjectFirst-episode schizophreniaen_HK
dc.subjectPeriod of untreated psychosisen_HK
dc.subjectQuality of lifeen_HK
dc.titleImpact of untreated psychosis on quality of life in patients with first-episode schizophreniaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0962-9343&volume=14&spage=1803&epage=1811&date=2005&atitle=Impact+of+Untreated+Psychosis+on+Quality+of+Life+in+Patients+with+First-episode+Schizophreniaen_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailLam, CLK: clklam@hku.hken_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.identifier.authorityLam, CLK=rp00350en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s11136-005-3236-6en_HK
dc.identifier.pmid16155768-
dc.identifier.scopuseid_2-s2.0-24644448436en_HK
dc.identifier.hkuros116240en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-24644448436&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1803en_HK
dc.identifier.epage1811en_HK
dc.identifier.isiWOS:000231807200002-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLaw, CW=8627115600en_HK
dc.identifier.scopusauthoridChen, EYH=7402315729en_HK
dc.identifier.scopusauthoridCheung, EFC=7006522469en_HK
dc.identifier.scopusauthoridChan, RCK=35236280300en_HK
dc.identifier.scopusauthoridWong, JGWS=7404435750en_HK
dc.identifier.scopusauthoridLam, CLK=24755913900en_HK
dc.identifier.scopusauthoridLeung, KF=16244973800en_HK
dc.identifier.scopusauthoridLo, MSM=7101896986en_HK
dc.identifier.citeulike319507-

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