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Article: Radiofrequency ablation for hypersplenism in patients with liver cirrhosis: A pilot study

TitleRadiofrequency ablation for hypersplenism in patients with liver cirrhosis: A pilot study
Authors
KeywordsHypersplenism
Liver cirrhosis
Portal hypertension
Radiofrequency ablation
Spleen
Issue Date2005
PublisherSpringer New York LLC.
Citation
Journal Of Gastrointestinal Surgery, 2005, v. 9 n. 5, p. 648-657 How to Cite?
AbstractRadiofrequency ablation is a relatively new technique used for local ablation of unresectable tumors. We investigated the feasibility and efficacy of radiofrequency ablation for hypersplenism and its effect on liver function in patients with liver cirrhosis and portal hypertension. Nine consecutive patients with hypersplenism due to cirrhotic portal hypertension underwent radiofrequency ablation in enlarged spleens. The ablation was performed either intraoperatively or percutaneously. Patients are followed up for over 12 months. After treatment, between 20% and 43% of spleen volume was ablated, and spleen volume increased by 4%-10.2%. White blood cell count, platelet count, liver function, and hepatic artery blood flow showed significant improvement after 1-year follow-up. Splenic vein and portal vein blood flow were significantly reduced. Only minor complications including hydrothorax (three of nine patients) and mild abdominal pain (four of nine patients) were observed. No mortality or other morbidity occurred. Radiofrequency ablation is a safe, effective, and minimally invasive approach for the management of splenomegaly and hypersplenism in patients with liver cirrhosis and portal hypertension. Increased hepatic artery blood flow may be responsible for sustained improvement of liver condition. Radiofrequency ablation may be used as a bridging therapy for cirrhotic patients waiting for liver transplantation. © 2005 The Society for Surgery of the Alimentary Tract.
Persistent Identifierhttp://hdl.handle.net/10722/78464
ISSN
2015 Impact Factor: 2.807
2015 SCImago Journal Rankings: 1.640
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Qen_HK
dc.contributor.authorMa, Ken_HK
dc.contributor.authorHe, Zen_HK
dc.contributor.authorDong, Jen_HK
dc.contributor.authorHua, Xen_HK
dc.contributor.authorHuang, Xen_HK
dc.contributor.authorQiao, Len_HK
dc.date.accessioned2010-09-06T07:43:11Z-
dc.date.available2010-09-06T07:43:11Z-
dc.date.issued2005en_HK
dc.identifier.citationJournal Of Gastrointestinal Surgery, 2005, v. 9 n. 5, p. 648-657en_HK
dc.identifier.issn1091-255Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/78464-
dc.description.abstractRadiofrequency ablation is a relatively new technique used for local ablation of unresectable tumors. We investigated the feasibility and efficacy of radiofrequency ablation for hypersplenism and its effect on liver function in patients with liver cirrhosis and portal hypertension. Nine consecutive patients with hypersplenism due to cirrhotic portal hypertension underwent radiofrequency ablation in enlarged spleens. The ablation was performed either intraoperatively or percutaneously. Patients are followed up for over 12 months. After treatment, between 20% and 43% of spleen volume was ablated, and spleen volume increased by 4%-10.2%. White blood cell count, platelet count, liver function, and hepatic artery blood flow showed significant improvement after 1-year follow-up. Splenic vein and portal vein blood flow were significantly reduced. Only minor complications including hydrothorax (three of nine patients) and mild abdominal pain (four of nine patients) were observed. No mortality or other morbidity occurred. Radiofrequency ablation is a safe, effective, and minimally invasive approach for the management of splenomegaly and hypersplenism in patients with liver cirrhosis and portal hypertension. Increased hepatic artery blood flow may be responsible for sustained improvement of liver condition. Radiofrequency ablation may be used as a bridging therapy for cirrhotic patients waiting for liver transplantation. © 2005 The Society for Surgery of the Alimentary Tract.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC.en_HK
dc.relation.ispartofJournal of Gastrointestinal Surgeryen_HK
dc.subjectHypersplenismen_HK
dc.subjectLiver cirrhosisen_HK
dc.subjectPortal hypertensionen_HK
dc.subjectRadiofrequency ablationen_HK
dc.subjectSpleenen_HK
dc.titleRadiofrequency ablation for hypersplenism in patients with liver cirrhosis: A pilot studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1091-255X&volume=5&spage=648&epage=657&date=2005&atitle=Radiofrequency+ablation+for+hypersplenism+in+patients+with+liver+cirrhosis:+a+pilot+study.en_HK
dc.identifier.emailQiao, L: lq8688@hotmail.comen_HK
dc.identifier.authorityQiao, L=rp00513en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.gassur.2004.11.006en_HK
dc.identifier.pmid15862259-
dc.identifier.scopuseid_2-s2.0-18044396724en_HK
dc.identifier.hkuros132389en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-18044396724&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume9en_HK
dc.identifier.issue5en_HK
dc.identifier.spage648en_HK
dc.identifier.epage657en_HK
dc.identifier.isiWOS:000229251800005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiu, Q=8590747200en_HK
dc.identifier.scopusauthoridMa, K=7202837279en_HK
dc.identifier.scopusauthoridHe, Z=7403885282en_HK
dc.identifier.scopusauthoridDong, J=7403361614en_HK
dc.identifier.scopusauthoridHua, X=36817180000en_HK
dc.identifier.scopusauthoridHuang, X=8354378800en_HK
dc.identifier.scopusauthoridQiao, L=7202151719en_HK

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