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Article: Highly successful long-term outcome of kidney transplantation in Chinese recipients: An enhancing race effect?

TitleHighly successful long-term outcome of kidney transplantation in Chinese recipients: An enhancing race effect?
Authors
Issue Date1997
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CTR
Citation
Clinical Transplantation, 1997, v. 11 n. 3, p. 178-184 How to Cite?
AbstractWe report on 352 cadaveric kidney transplants and 294 living related transplants performed over a 25-yr period among the Chinese population of Hong Kong. There is a marked preference for transplanting male patients, especially from living donors, and we argue that this represents a cultural phenomenon within the Chinese population. The 10-yr graft survivals for related and cadaveric transplants are 86.2% and 67.4%, respectively. These figures are appreciably higher than corresponding figures in Caucasian populations. We show beneficial effects of using cyclosporin A, minimizing the cold ischemia time and avoiding very young and very old donors. There is a clear benefit of transplanting kidneys with zero or one mismatched HLA antigen against the recipient but no stepwise decrease in outcome as the number of mismatched antigens increases. There is close concordance between the outcome of living related grafts with zero, one, and two mismatched haplotypes against the recipient and no observable benefit of haplotype matching. We show that Chinese renal transplant recipients in other centers also have better long-term graft outcome than Caucasians, both for cadaveric and living related transplants. We draw attention to the existence of a detrimental 'race effect' in other studies when Black recipients are compared with Caucasians and consider whether an enhancing race effect exists for Chinese or whether the better outcome reflects different underlying diseases in Chinese.
Persistent Identifierhttp://hdl.handle.net/10722/78441
ISSN
2015 Impact Factor: 1.844
2015 SCImago Journal Rankings: 0.821
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHawkins, BRen_HK
dc.contributor.authorChan, Pen_HK
dc.contributor.authorChan, YTen_HK
dc.contributor.authorCheng, IKPen_HK
dc.contributor.authorCheung, KOen_HK
dc.contributor.authorFenn, Jen_HK
dc.contributor.authorHo, KKen_HK
dc.contributor.authorLai, KNen_HK
dc.contributor.authorLi, CSen_HK
dc.contributor.authorLui, SFen_HK
dc.contributor.authorOpelz, Gen_HK
dc.contributor.authorTong, MKLen_HK
dc.date.accessioned2010-09-06T07:42:55Z-
dc.date.available2010-09-06T07:42:55Z-
dc.date.issued1997en_HK
dc.identifier.citationClinical Transplantation, 1997, v. 11 n. 3, p. 178-184en_HK
dc.identifier.issn0902-0063en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78441-
dc.description.abstractWe report on 352 cadaveric kidney transplants and 294 living related transplants performed over a 25-yr period among the Chinese population of Hong Kong. There is a marked preference for transplanting male patients, especially from living donors, and we argue that this represents a cultural phenomenon within the Chinese population. The 10-yr graft survivals for related and cadaveric transplants are 86.2% and 67.4%, respectively. These figures are appreciably higher than corresponding figures in Caucasian populations. We show beneficial effects of using cyclosporin A, minimizing the cold ischemia time and avoiding very young and very old donors. There is a clear benefit of transplanting kidneys with zero or one mismatched HLA antigen against the recipient but no stepwise decrease in outcome as the number of mismatched antigens increases. There is close concordance between the outcome of living related grafts with zero, one, and two mismatched haplotypes against the recipient and no observable benefit of haplotype matching. We show that Chinese renal transplant recipients in other centers also have better long-term graft outcome than Caucasians, both for cadaveric and living related transplants. We draw attention to the existence of a detrimental 'race effect' in other studies when Black recipients are compared with Caucasians and consider whether an enhancing race effect exists for Chinese or whether the better outcome reflects different underlying diseases in Chinese.en_HK
dc.languageengen_HK
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CTRen_HK
dc.relation.ispartofClinical Transplantationen_HK
dc.subject.meshActuarial Analysisen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAfrican Continental Ancestry Groupen_HK
dc.subject.meshAge Factorsen_HK
dc.subject.meshAsian Continental Ancestry Groupen_HK
dc.subject.meshCadaveren_HK
dc.subject.meshChina - ethnologyen_HK
dc.subject.meshCryopreservationen_HK
dc.subject.meshCultureen_HK
dc.subject.meshCyclosporine - therapeutic useen_HK
dc.subject.meshEuropean Continental Ancestry Groupen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshGraft Survivalen_HK
dc.subject.meshHLA Antigens - analysisen_HK
dc.subject.meshHaplotypesen_HK
dc.subject.meshHistocompatibilityen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunosuppressive Agents - therapeutic useen_HK
dc.subject.meshKidney Diseases - physiopathologyen_HK
dc.subject.meshKidney Transplantation - statistics & numerical dataen_HK
dc.subject.meshLiving Donors - statistics & numerical dataen_HK
dc.subject.meshLongitudinal Studiesen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshSex Factorsen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.titleHighly successful long-term outcome of kidney transplantation in Chinese recipients: An enhancing race effect?en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0902-0063&volume=11&spage=178&epage=184&date=1997&atitle=Highly+successful+long-term+outcome+of+kidney+transplantation+in+Chinese+recipients:+An+enhancing+race+effect?en_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9193839-
dc.identifier.scopuseid_2-s2.0-8244241758en_HK
dc.identifier.hkuros41371en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-8244241758&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue3en_HK
dc.identifier.spage178en_HK
dc.identifier.epage184en_HK
dc.identifier.isiWOS:A1997XE58600005-
dc.publisher.placeDenmarken_HK
dc.identifier.scopusauthoridHawkins, BR=35944486200en_HK
dc.identifier.scopusauthoridChan, P=7403497705en_HK
dc.identifier.scopusauthoridChan, YT=7403676557en_HK
dc.identifier.scopusauthoridCheng, IKP=7102537483en_HK
dc.identifier.scopusauthoridCheung, KO=7402406558en_HK
dc.identifier.scopusauthoridFenn, J=17534025300en_HK
dc.identifier.scopusauthoridHo, KK=36819421100en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridLi, CS=36068236000en_HK
dc.identifier.scopusauthoridLui, SF=7102379144en_HK
dc.identifier.scopusauthoridOpelz, G=7102401581en_HK
dc.identifier.scopusauthoridTong, MKL=7202033848en_HK

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